Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model
Open accessAbstract
Increasing NAD + levels by supplementing with the precursor nicotinamide mononucleotide (NMN) improves cardiac function in multiple mouse models of disease. While NMN influences several aspects of mitochondrial metabolism, the molecular mechanisms by which increased NAD + enhances cardiac function are poorly understood. A putative mechanism of NAD + therapeutic action exists via activation of the mitochondrial NAD + -dependent protein deacetylase sirtuin 3 (SIRT3). We assessed the therapeutic efficacy of NMN and the role of SIRT3 in the Friedreich’s ataxia cardiomyopathy mouse model (FXN-KO). At baseline, the FXN-KO heart has mitochondrial protein hyperacetylation, reduced Sirt3 mRNA expression, and evidence of increased NAD + salvage. Remarkably, NMN administered to FXN-KO mice restores cardiac function to near-normal levels. To determine whether SIRT3 is required for NMN therapeutic efficacy, we generated SIRT3-KO and SIRT3-KO/FXN-KO (double KO [dKO]) models. The improvement in cardiac function upon NMN treatment in the FXN-KO is lost in the dKO model, demonstrating that the effects of NMN are dependent upon cardiac SIRT3. Coupled with cardio-protection, SIRT3 mediates NMN-induced improvements in both cardiac and extracardiac metabolic function and energy metabolism. Taken together, these results serve as important preclinical data for NMN supplementation or SIRT3 activator therapy in Friedreich’s ataxia patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SIRT3 mediates NMN-induced improvements in cardiac and extracardiac metabolic function in a mouse model of cardiomyopathy.
“SIRT3 mediates NMN-induced improvements in cardiac and extracardiac metabolic function in a mouse model of cardiomyopathy207.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [207]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
affy—analysis of Affymetrix GeneChip data at the probe level
Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,221 · see citing works
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291 · see citing works
Self-citationCantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238 · see citing works
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-07 · Cited by 1,216 · see citing works
Self-citationCardiac Metabolism in Heart Failure
Doenst, T., Nguyễn, T. D., & Abel, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.300376 · Cited by 1,104 · see citing works
Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.013 · Cited by 930 · see citing works
Mitochondrial function as a therapeutic target in heart failure
Brown, D. A., Perry, J. B., Allen, M. E., Sabbah, H. N., Stauffer, B. L., Shaikh, S. R., Cleland, J. G. F., Colucci, W. S., Butler, J., Voors, A. A., et al. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.203 · Cited by 811 · see citing works
Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
Kolwicz, S. C., Purohit, S., & Tian, R. (2013) · Circulation Research · doi:10.1161/circresaha.113.302095 · Cited by 810 · see citing works
Neubauer, S., Horn, M., Cramer, M., Harre, K., Newell, J. B., Peters, W., Pabst, T., Ertl, G., Hahn, D., Ingwall, J. S., et al. (1997) · Circulation · doi:10.1161/01.cir.96.7.2190 · Cited by 748 · see citing works
Suga, H. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.247 · Cited by 744 · see citing works
Puccio, H., Simon, D., Cossée, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P., & Koenig, M. (2001) · Nature Genetics · doi:10.1038/84818 · Cited by 738 · see citing works
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697 · see citing works
Isobaric Labeling-Based Relative Quantification in Shotgun Proteomics
Rauniyar, N., & Yates, J. R. (2014) · Journal of Proteome Research · doi:10.1021/pr500880b · Cited by 597 · see citing works
Hafner, A. V., Dai, J., Gomes, A. P., Xiao, C., Palmeira, C. M., Rosenzweig, A., & Sinclair, D. A. (2010) · Aging · doi:10.18632/aging.100252 · Cited by 542 · see citing works
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
Tran, M. T., Zsengellér, Z. K., Berg, A. H., Khankin, E. V., Bhasin, M., Kim, W., Clish, C. B., Stillman, I. E., Karumanchi, S. A., Rhee, E. P., et al. (2016) · Nature · doi:10.1038/nature17184 · Cited by 539 · see citing works
Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
Karamanlidis, G., Lee, C. F., Garcia‐Menendez, L., Kolwicz, S. C., Suthammarak, W., Gong, G., Sedensky, M. M., Morgan, P. G., Wang, W., & Tian, R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.002 · Cited by 469 · see citing works
Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics
Koeppen, A. H. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.01.010 · Cited by 447 · see citing works
Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis
Wilson, C., & Miller, C. J. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti605 · Cited by 447 · see citing works
Weissler, A. M., Peeler, R. G., & Roehll, W. H. (1961) · American Heart Journal · doi:10.1016/0002-8703(61)90403-3 · Cited by 440 · see citing works
Heart Failure: Diagnosis, Management and Utilization
Inamdar, A. A., & Inamdar, A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5070062 · Cited by 422 · see citing works
Pillai, V. B., Sundaresan, N. R., Kim, G. H., Gupta, M., Rajamohan, S. B., Pillai, J. B., Samant, S. A., Ravindra, P. A., Isbatan, A., & Gupta, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077271 · Cited by 420 · see citing works
Pillai, J. B., Isbatan, A., Imai, S., & Gupta, M. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506162200 · Cited by 391 · see citing works
Dujardin, K., Tei, C., Yeo, T. C., Hodge, D. O., Rossi, A., & Seward, J. B. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00559-1 · Cited by 382 · see citing works
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Ratajczak, J., Joffraud, M., Trammell, S. A. J., Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13103 · Cited by 378 · cited 1× · see citing works
“Increased Nmrk2 suggests an enhanced capacity of the FXN-KO heart to take up exogenous NAD+ precursors NR and NMN (27), and decreased Nampt suggests reduced de novo synthesis of NAD+ in the FXN-KO heart.”
BackgroundLoss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle
Frederick, D. W., Loro, E., Liu, L., Davila, A., Chellappa, K., Silverman, I. M., Quinn, W. J., Gosai, S. J., Tichy, E. D., Davis, J. G., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.005 · Cited by 367 · cited 1× · see citing works
“Interestingly, NMN supplementation normalized serum lactate levels in the FXN-KO mouse as compared with WT mice (Figure 6A), consistent with the literature, which shows reduced lactic acidosis in NMN-treated exercised mice (44).”
ResultLipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
McDonnell, E., Crown, S. B., Fox, D. B., Kitir, B., Ilkayeva, O., Olsen, C. A., Grimsrud, P. A., & Hirschey, M. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.012 · Cited by 342 · see citing works
Self-citationNormalization of NAD + Redox Balance as a Therapy for Heart Failure
Lee, C. F., Chavez, J. D., Garcia‐Menendez, L., Choi, Y. S., Roe, N. D., Chiao, Y. A., Edgar, J. S., Goo, Y. A., Goodlett, D. R., Bruce, J. E., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.022495 · Cited by 337 · see citing works
Pacher, P., & Szabó, C. (2007) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2007.00018.x · Cited by 317 · see citing works
Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098972 · Cited by 305 · see citing works
Glucose metabolism and cardiac hypertrophy
Kolwicz, S. C., & Tian, R. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr071 · Cited by 302 · see citing works
Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart
Xu, W., Barrientos, T., Mao, L., Rockman, H. A., Sauve, A. A., & Andrews, N. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.023 · Cited by 274 · see citing works
Self-citationMeasuring Energy Metabolism in the Mouse – Theoretical, Practical, and Analytical Considerations
Speakman, J. R. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00034 · Cited by 268 · see citing works
A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation
Wagner, G. R., Bhatt, D. P., O’Connell, T. M., Thompson, J. W., Dubois, L. G., Backos, D. S., Yang, H., Mitchell, G. A., Ilkayeva, O. R., Stevens, R. D., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.006 · Cited by 258 · see citing works
Self-citationPerdomini, M., Belbellaa, B., Monassier, L., Reutenauer, L., Messaddeq, N., Cartier, N., Crystal, R. G., Aubourg, P. R., & Puccio, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3510 · Cited by 238 · see citing works
Even, P. C., & Nadkarni, N. A. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00137.2012 · Cited by 237 · see citing works
Alrob, O. A., Sankaralingam, S., Ma, C., Wagg, C. S., Fillmore, N., Jaswal, J. S., Sack, M. N., Lehner, R. S., Gupta, M. P., Michelakis, E. D., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu156 · Cited by 221 · see citing works
Cardiac Efficiency Is Improved After Ischemia by Altering Both the Source and Fate of Protons
Liu, B., Clanachan, A. S., Schulz, R., & Lopaschuk, G. D. (1996) · Circulation Research · doi:10.1161/01.res.79.5.940 · Cited by 218 · see citing works
Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases
Hershberger, K. A., Martin, A. S., & Hirschey, M. D. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.5 · Cited by 218 · see citing works
Self-citationSIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts
Porter, G. A., Jr., Urciuoli, W. R., Brookes, P. S., & Nadtochiy, S. M. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00027.2014 · Cited by 212 · see citing works
Huang, M. L.-H., Becker, E. M., Whitnall, M., Rahmanto, Y. S., Ponka, P., & Richardson, D. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906784106 · Cited by 212 · see citing works
Mitochondrial protein hyperacetylation in the failing heart
Horton, J. L., Martin, O. J., Lai, L., Riley, N. M., Richards, A., Vega, R. B., Leone, T. C., Pagliarini, D. J., Muoio, D. M., Bedi, K. C., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.84897 · Cited by 208 · see citing works
SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching
Dittenhafer‐Reed, K. E., Richards, A., Fan, J., Smallegan, M. J., Siahpirani, A. F., Kemmerer, Z. A., Prolla, T. A., Roy, S., Coon, J. J., & Denu, J. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.007 · Cited by 189 · see citing works
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment
Lee, L. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.02.018 · Cited by 179 · see citing works
Lantier, L., Williams, A. S., Williams, I. M., Yang, K. K., Bracy, D. P., Goelzer, M., James, F. D., Gius, D., & Wasserman, D. H. (2015) · Diabetes · doi:10.2337/db14-1810 · Cited by 151 · see citing works
Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions
Weinert, B. T., Moustafa, T., Iešmantavičius, V., Zechner, R., & Choudhary, C. (2015) · The EMBO Journal · doi:10.15252/embj.201591271 · Cited by 150 · see citing works
Myocardial energetics in heart failure
Nickel, A. G., Löffler, J., & Maack, C. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0358-9 · Cited by 143 · see citing works
Fernandez-Marcos, P. J., Jeninga, E. H., Canto, C., Harach, T., de Boer, V. C. J., Andreux, P., Moullan, N., Pirinen, E., Yamamoto, H., Houten, S. M., et al. (2012) · Scientific Reports · doi:10.1038/srep00425 · Cited by 137 · see citing works
Free fatty acid kinetics and oxidation in congestive heart failure.
Lommi, J., Kupari, M., & Yki-Järvinen, H. (1998) · American Journal of Cardiology · doi:10.1016/s0002-9149(97)00804-7 · Cited by 130 · see citing works
Cardiomyopathy of Friedreich Ataxia
Weidemann, F., Störk, S., Liu, D., Hu, K., Herrmann, S., Ertl, G., & Niemann, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12217 · Cited by 109 · see citing works
Liu, X., Sadhukhan, S., Sun, S., Wagner, G. R., Hirschey, M. D., Qi, L., Lin, H., & Locasale, J. W. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.044859 · Cited by 108 · see citing works
Self-citationYoo, B., Lemaire, A., Mangmool, S., Wolf, M. J., Curcio, A., Mao, L., & Rockman, H. A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00504.2009 · Cited by 108 · see citing works
Self-citationXiao, C.-Y., Chen, M., Zsengellér, Z. K., Li, H., Kiss, L., Kollai, M., & Szabó, C. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.077164 · Cited by 106 · see citing works
Albarado, D. C., McClaine, J. W., Stephens, J. M., Mynatt, R. L., Ye, J., Bannon, A. W., Richards, W. G., & Butler, A. A. (2003) · Endocrinology · doi:10.1210/en.2003-0452 · Cited by 103 · see citing works
Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D. B., Jensen, L. J., & Choudhary, C. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m117.067587 · Cited by 98 · see citing works
Fragasso, G., Rosano, G. M. C., Baek, S. H., Sisakian, H. S., Napoli, P. D., Alberti, L., Calori, G., Kang, S., Sahakyan, L. G., Sanosyan, A., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.123 · Cited by 96 · see citing works
Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6
Cai, Y., Yu, S., Chen, S., Pi, R., Gao, S., Li, H., Ye, J., & Liu, P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.02.014 · Cited by 92 · see citing works
Left ventricular function: time-varying elastance and left ventricular aortic coupling
Walley, K. R. (2016) · Critical Care · doi:10.1186/s13054-016-1439-6 · Cited by 90 · see citing works
Fragasso, G., Salerno, A., Lattuada, G., Cuko, A., Calori, G., Scollo, A., Ragogna, F., Arioli, F., Bassanelli, G., Spoladore, R., et al. (2011) · Heart · doi:10.1136/hrt.2011.226332 · Cited by 88 · see citing works
Ventricular energetics after the Fontan operation: Contractility-afterload mismatch
Szabo, G. B., Buhmann, V., Graf, A., Melnitchuk, S., Bährle, S., Vahl, C. F., & Hagl, S. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2003.405 · Cited by 77 · see citing works
Fueger, P. T., Heikkinen, S., Bracy, D. P., Malabanan, C. M., Pencek, R., Laakso, M., & Wasserman, D. H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2003 · Cited by 72 · see citing works
Wagner, G. R., Pride, P. M., Babbey, C. M., & Payne, R. M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds095 · Cited by 71 · see citing works
Self-citationChruściel, P., Rysz, J., & Banach, M. (2014) · Drugs · doi:10.1007/s40265-014-0233-5 · Cited by 70 · see citing works
Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts.
Finegan, B. A., Lopaschuk, G. D., Coulson, C. S., & Clanachan, A. S. (1993) · Circulation · doi:10.1161/01.cir.87.3.900 · Cited by 69 · see citing works
Hata, K., Takasago, T., Saeki, A., Nishioka, T., & Goto, Y. (1994) · Circulation Research · doi:10.1161/01.res.74.5.794 · Cited by 61 · see citing works
Güneş, Y., Güntekin, Ü., Tuncer, M., & Şahin, M. (2009) · Heart and Vessels · doi:10.1007/s00380-008-1118-x · Cited by 41 · see citing works
The redox state of the nicotinamide–adenine dinucleotides in rat liver homogenates
Krebs, H. A., & Gascoyne, T. (1968) · Biochemical Journal · doi:10.1042/bj1080513 · Cited by 36 · see citing works
Adenosine modification of energy substrate use in isolated hearts perfused with fatty acids
Finegan, B. A., Clanachan, A. S., Coulson, C. S., & Lopaschuk, G. D. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.5.h1501 · Cited by 31 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Xu W, Barrientos T, Mao L, Rockman HA, Sauve AA, Andrews NC. Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. Cell Rep. 2015;13(3):533-545. · DOI
- Payne RM, et al. Fatty acid oxidation is disrupted in the FRDA heart. Presented at: International Ataxia Research Conference; March 28, 2015; Windsor, United Kingdom. Session 6.
- Smyth GK. LIMMA: linear models for microarray data. In: Genlteman R, Carey V, Huber W, Irizarry R, Dudoit S, eds. Bioin- formatics and Computational Biology Solutions Using R and Bioconductor. New York, NY: Springer-Verlag New York;2005:397-420.
Cited by
Sorted by citations
Mechanisms of physiological and pathological cardiac hypertrophy
Nakamura, M., & Sadoshima, J. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0007-y · Cited by 1,662 · see citing works
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works
Cardiac Energy Metabolism in Heart Failure
Lopaschuk, G. D., Karwi, Q. G., Tian, R., Wende, A. R., & Abel, E. D. (2021) · Circulation Research · doi:10.1161/circresaha.121.318241 · Cited by 1,420 · see citing works
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.002 · Cited by 1,061 · see citing works
Mitochondrial dysfunction in pathophysiology of heart failure
Zhou, B., & Tian, R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120849 · Cited by 934 · see citing works
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865 · see citing works
Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 490 · see citing works
Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
Bonora, M., Wieckowski, M. R., Sinclair, D. A., Kroemer, G., Pinton, P., & Galluzzi, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0074-0 · Cited by 299 · see citing works
NAD + Metabolism in Cardiac Health, Aging, and Disease
Abdellatif, M., Sedej, S., & Kroemer, G. (2021) · Circulation · doi:10.1161/circulationaha.121.056589 · Cited by 262 · see citing works
NAD + Repletion Reverses Heart Failure With Preserved Ejection Fraction
Tong, D., Schiattarella, G. G., Jiang, N., Altamirano, F. J., Szweda, P. A., Elnwasany, A., Lee, D. I., Yoo, H., Kass, D. A., Szweda, L. I., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.317046 · Cited by 240 · see citing works
NADH Autofluorescence—A Marker on its Way to Boost Bioenergetic Research
Schaefer, P. M., Kalinina, S., Rueck, A. C., Arnim, C. A. F. V., & von Einem, B. (2018) · Cytometry Part A · doi:10.1002/cyto.a.23597 · Cited by 228 · see citing works
Hong, W., Mo, F., Zhang, Z., Huang, M., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00246 · Cited by 179 · see citing works
Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule
Poddar, S. K., Sifat, A. E., Haque, S., Nahid, N. A., Chowdhury, S., & Mehedi, I. (2019) · Biomolecules · doi:10.3390/biom9010034 · Cited by 136 · see citing works
Unlocking the Secrets of Mitochondria in the Cardiovascular System
Tian, R., Colucci, W. S., Arany, Z. P., Bachschmid, M. M., Ballinger, S. W., Boudina, S., Bruce, J. E., Busija, D. W., Dikalov, S., Dorn, G. W., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040551 · Cited by 133 · see citing works
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury
Feng, Z., Qin, Y., Huo, F., Jian, Z., Li, X., Geng, J., Li, Y., & Wu, J. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166287 · Cited by 123 · see citing works
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song, Q., Zhou, X., Xu, K., Liu, S., Zhu, X., & Yang, J. J. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.08.008 · Cited by 122 · see citing works
Yamamura, S., Izumiya, Y., Araki, S., Nakamura, T., Kimura, Y., Hanatani, S., Yamada, T., Ishida, T., Yamamoto, M., Onoue, Y., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13357 · Cited by 119 · see citing works
Sirtuin 5 is required for mouse survival in response to cardiac pressure overload
Hershberger, K. A., Abraham, D., Martin, A. S., Mao, L., Liu, J., Gu, H., Locasale, J. W., & Hirschey, M. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.809897 · Cited by 105 · see citing works
Self-citationLiao, B., Zhao, Y., Wang, D., Zhang, X., Xuan-ming, H., & Hu, M. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00442-4 · Cited by 96 · see citing works
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
Braidy, N., & Liu, Y. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110831 · Cited by 96 · see citing works
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction
Wang, D. D., Airhart, S. E., Zhou, B., Shireman, L. M., Jiang, S., Rodriguez, C. M., Kirkpatrick, J. N., Shen, D. D., Tian, R., & O’Brien, K. D. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.06.012 · Cited by 89 · see citing works
Mitochondrial quality control in health and cardiovascular diseases
Atici, A. E., Crother, T. R., & Rivas, M. N. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1290046 · Cited by 83 · see citing works
Toward understanding genomic instability, mitochondrial dysfunction and aging
Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2019) · The FEBS Journal · doi:10.1111/febs.14663 · Cited by 77 · see citing works
Tannous, C., Booz, G. W., Altara, R., Muhieddine, D. H., Mericskay, M., Refaat, M. M., & Zouein, F. A. (2020) · Acta Physiologica · doi:10.1111/apha.13551 · Cited by 79 · see citing works
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure
Davidson, M. T., Grimsrud, P. A., Lai, L., Draper, J. A., Fisher‐Wellman, K. H., Narowski, T. M., Abraham, D., Koves, T. R., Kelly, D. P., & Muoio, D. M. (2020) · Circulation Research · doi:10.1161/circresaha.120.317293 · Cited by 76 · see citing works
Self-citationHigh Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models
Belbellaa, B., Reutenauer, L., Messaddeq, N., Monassier, L., & Puccio, H. M. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.08.018 · Cited by 75 · see citing works
Sanchez-Contreras, M., Sweetwyne, M. T., Tsantilas, K. A., Whitson, J. A., Campbell, M. D., Kohrn, B. F., Kim, H. J., Hipp, M. J., Fredrickson, J., Nguyen, M. M., et al. (2023) · eLife · doi:10.7554/elife.83395 · Cited by 71 · see citing works
Mitochondrial dysfunction in heart failure and its therapeutic implications
Liu, M., Lv, J., Pan, Z., Wang, D., Zhao, L., & Guo, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.945142 · Cited by 68 · see citing works
Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease
Matasic, D. S., Brenner, C., & London, B. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00409.2017 · Cited by 64 · see citing works
Walker, M. A., & Tian, R. (2018) · Circulation · doi:10.1161/circulationaha.117.032626 · Cited by 63 · see citing works
NAD(H) in mitochondrial energy transduction: implications for health and disease
Walker, M. A., & Tian, R. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.03.011 · Cited by 58 · see citing works
Vignier, N., Chatzifrangkeskou, M., Rodríguez, B. M., Mericskay, M., Mougenot, N., Wahbi, K., Bonne, G., & Muchir, A. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy278 · Cited by 57 · see citing works
Liu, L., Xie, Y., Li, G., Zhang, T., Sui, Y., Zhao, Z., Zhang, Y., Yang, W., Geng, X., Xue, D., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.15980 · Cited by 56 · see citing works
Koentges, C., Cimolai, M. C., Pfeil, K., Wolf, D., Marchini, T., Tarkhnishvili, A., Hoffmann, M. M., Odening, K. E., Diehl, P., Mühlen, C. V. Z., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.06.008 · Cited by 56 · see citing works
Williams, A. S., Koves, T. R., Davidson, M. T., Crown, S. B., Fisher‐Wellman, K. H., Torres, M. J., Draper, J. A., Narowski, T. M., Slentz, D. H., Lantier, L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.003 · Cited by 55 · see citing works
Self-citationPoljšak, B., Kovač, V., Špalj, S., & Milisav, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032959 · Cited by 58 · see citing works
Fisher‐Wellman, K. H., Draper, J. A., Davidson, M. T., Williams, A. S., Narowski, T. M., Slentz, D. H., Ilkayeva, O., Stevens, R. D., Wagner, G. R., Najjar, R. S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.057 · Cited by 49 · see citing works
Self-citationEmerging Roles of SIRT3 in Cardiac Metabolism
Murugasamy, K., Munjal, A., & Sundaresan, N. R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.850340 · Cited by 48 · see citing works
Hershberger, K. A., Abraham, D., Liu, J., Locasale, J. W., Grimsrud, P. A., & Hirschey, M. D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002187 · Cited by 46 · see citing works
Self-citationOmaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia
Profeta, V., McIntyre, K., Wells, M., Park, C. C., & Lynch, D. R. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2173063 · Cited by 46 · see citing works
Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism
Klimova, N., & Kristián, T. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02729-0 · Cited by 42 · see citing works
Walker, M. A., Chen, H., Yadav, A. S., Ritterhoff, J., Villet, O. M., McMillen, T. S., Wang, Y., Purcell, H. J., Djukovic, D., Raftery, D., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.066039 · Cited by 42 · see citing works
Belbellaa, B., Reutenauer, L., Monassier, L., & Puccio, H. M. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy427 · Cited by 40 · see citing works
Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo
Zhou, J., Ng, B., Ko, N. S. J., Fiedler, L. R., Khin, E. S. W., Lim, A. R., Sahib, N. B. E., Wu, Y., Chothani, S. P., Schäfer, S., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz033 · Cited by 39 · see citing works
SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside
Mukherjee, S., Mo, J., Paolella, L. M., Perry, C. E., Toth, J., Hugo, M., Chu, Q., Tong, Q., Chellappa, K., & Baur, J. A. (2021) · JCI Insight · doi:10.1172/jci.insight.147193 · Cited by 39 · see citing works
Caloric restriction mimetics for the treatment of cardiovascular diseases
Sciarretta, S., Forte, M., Castoldi, F., Frati, G., Versaci, F., Sadoshima, J., Kroemer, G., & Maiuri, M. C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa297 · Cited by 38 · see citing works
Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies
Poljšak, B., Kovač, V., & Milisav, I. (2022) · Antioxidants · doi:10.3390/antiox11091637 · Cited by 39 · see citing works
Chiang, S., Braidy, N., Maleki, S., Lal, S., Richardson, D. R., & Huang, M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102038 · Cited by 35 · see citing works
Improving lysosomal ferroptosis with NMN administration protects against heart failure
Yagi, M., Do, Y., Hirai, H., Miki, K., Toshima, T., Fukahori, Y., Setoyama, D., Abe, C., Nabeshima, Y., Kang, D., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302116 · Cited by 36 · see citing works
Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism
Karwi, Q. G., Joerg, A. R., & Lopaschuk, G. D. (2019) · Biochemical Journal · doi:10.1042/bcj20180617 · Cited by 37 · see citing works
Post-translational Acetylation Control of Cardiac Energy Metabolism
Ketema, E. B., & Lopaschuk, G. D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.723996 · Cited by 37 · see citing works
Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging
Rahman, S. U., Qadeer, A., & Wu, Z. (2024) · Aging and disease · doi:10.14336/ad.2023.0519-1 · Cited by 34 · see citing works
Ramanathan, C., Lackie, T., Williams, D. H., Simone, P. S., Zhang, Y., & Bloomer, R. J. (2022) · Nutrients · doi:10.3390/nu14020300 · Cited by 33 · see citing works
Luo, C., Ding, W., Yang, C., Zhang, W., Liu, X., & Deng, H. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00167 · Cited by 33 · see citing works
Self-citationAgeing and longevity genes in cardiovascular diseases
Liberale, L., Kraler, S. C., Camici, G. G., & Lüscher, T. F. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13426 · Cited by 33 · see citing works
Xu, W., Li, L., & Zhang, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00901 · Cited by 33 · see citing works
Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases
Rotllán, N., Camacho, M., Tondo, M., Diarte‐Añazco, E. M. G., Canyelles, M., Méndez‐Lara, K. A., Benı́tez, S., Alonso, N., Mauricio, D., Escolá‐Gil, J. C., et al. (2021) · Antioxidants · doi:10.3390/antiox10121939 · Cited by 31 · see citing works
Sedley, L. (2020) · Epigenetics Insights · doi:10.1177/2516865720981924 · Cited by 29 · see citing works
Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration
Liu, S., Deshmukh, V., Meng, F., Wang, Y., Morikawa, Y., Steimle, J. D., Li, G., Wang, J., & Martin, J. F. (2024) · Circulation · doi:10.1161/circulationaha.123.067646 · Cited by 29 · see citing works
NAD+ and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities
Abdellatif, M., Bugger, H., Kroemer, G., & Sedej, S. (2022) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2022.11.2.111 · Cited by 26 · see citing works
Wu, W., Yuan, S., Tang, Y., Meng, X., Peng, M., Hu, Z., & Liu, W. (2023) · Nutrients · doi:10.3390/nu15132851 · Cited by 26 · see citing works
Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide
Zheng, C., Li, Y., Wu, X., Gao, L., & Chen, X. (2024) · Nutrients · doi:10.3390/nu16142354 · Cited by 26 · see citing works
Advancements in NMN biotherapy and research updates in the field of digestive system diseases
Liao, G., Xie, Y., Peng, H., Li, T., Zou, X., Yue, F., Guo, J., & Rong, L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05614-9 · Cited by 27 · see citing works
Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology
Ianni, A., Yuan, X., Bober, E., & Braun, T. W. (2018) · Pediatric Cardiology · doi:10.1007/s00246-018-1848-1 · Cited by 26 · see citing works
Li, P., Newhardt, M. F., Matsuzaki, S., Eyster, C. A., Pranay, A., Peelor, F. F., Batushansky, A., Kinter, C. S., Subramani, K., SUBRAHMANIAN, S. M., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00695-0 · Cited by 26 · see citing works
Assiri, M. A., Ali, H., Marentette, J., Yun, Y., Liu, J., Hirschey, M. D., Saba, L. M., Harris, P. S., & Fritz, K. S. (2019) · Human Genomics · doi:10.1186/s40246-019-0251-1 · Cited by 25 · see citing works
Self-citationBenjamin, C., & Crews, R. (2024) · Metabolites · doi:10.3390/metabo14060341 · Cited by 25 · see citing works
NAD metabolism and heart failure: Mechanisms and therapeutic potentials
Walker, M. A., & Tian, R. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.07.008 · Cited by 24 · see citing works
Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver
Luo, C., Ding, W., Zhu, S., Chen, Y., Liu, X., & Deng, H. (2022) · Cells · doi:10.3390/cells11101654 · Cited by 24 · see citing works
Self-citationNAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice
Kim, H.-W., Ryoo, G.-H., Jang, H., Rah, S., Lee, D. H., Kim, D., Bae, E. J., & Park, B. (2022) · Theranostics · doi:10.7150/thno.69684 · Cited by 29 · see citing works
Cardiovascular Research in Friedreich Ataxia
Payne, R. M. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.04.005 · Cited by 25 · see citing works
Self-citationNicotinamide Mononucleotide: Research Process in Cardiovascular Diseases
Deng, H., Ding, D., Ma, Y., Zhang, H., Wang, N., Zhang, C., & Yang, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179526 · Cited by 23 · see citing works
Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging
Drekolia, M.-K., Karantanou, C., Wittig, I., Li, Y., Fuhrmann, D. C., Brüne, B., Katsouda, A., Hu, J., Papapetropoulos, A., & Bibli, S. (2023) · Redox Biology · doi:10.1016/j.redox.2023.103014 · Cited by 22 · see citing works
Sanz‐Alcázar, A., Britti, E., Delaspre, F., Medina‐Carbonero, M., Pazos-Gil, M., Tamarit, J., Ros, J., & Cabiscol, E. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05064-4 · Cited by 21 · see citing works
Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells
Kolotyeva, N. A., Groshkov, A. A., Rozanova, N. A., Berdnikov, A. K., Novikova, S. V., Komleva, Y. K., Salmina, A. B., Illarioshkin, S. N., & Пирадов, М. А. (2024) · Biomolecules · doi:10.3390/biom14121556 · Cited by 22 · see citing works
Cellular pathophysiology of Friedreich's ataxia cardiomyopathy
Lees, J. G., Напиерала, М., Pébay, A., Dottori, M., & Lim, S. Y. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.11.033 · Cited by 20 · see citing works
Wang, L., Peng, T., Deng, J., Gao, W., Wang, H., Luo, O. J., Huang, L., & Chen, G. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116272 · Cited by 19 · see citing works
Fan, Y., Zhao, H., Lu, L., & Wu, W. (2025) · Nutrients · doi:10.3390/nu17111855 · Cited by 19 · see citing works
Metabolite signaling in the heart
Flam, E. L., & Arany, Z. P. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00270-6 · Cited by 19 · see citing works
Safety Evaluation for Restorin® NMN, a NAD+ Precursor
Turner, J. R., Licollari, A., Mihalcea, E., & Tan, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.749727 · Cited by 18 · see citing works
NAD supplementation improves mitochondrial performance of cardiolipin mutants
Ji, J., Damschroder, D., Bessert, D. A., Lazcano, P., Wessells, R. J., Reynolds, C. A., & Greenberg, M. L. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159094 · Cited by 17 · see citing works
Vásquez-Trincado, C., Patel, M., Sivaramakrishnan, A., Bekeová, C., Anderson‐Pullinger, L., Wang, N., Tang, H., & Seifert, E. L. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab216 · Cited by 13 · see citing works
Omoto, A. C. M., do Carmo, J. M., Nelson, B. J., Aitken, N. M., Dai, X., Moak, S. P., Flynn, E., Wang, Z., Mouton, A. J., Li, X., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027081 · Cited by 13 · see citing works
Liang, J., Zhou, C., Zhang, C., Liang, S., Zhou, Z., Zhou, Z., Wu, C., Zhao, H., Meng, X., Zou, F., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111328 · Cited by 13 · see citing works
Drug Repositioning in Friedreich Ataxia
Rufini, A., Malisan, F., Condò, I., & Testi, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.814445 · Cited by 13 · see citing works
Hall, A. R., Karwi, Q. G., Kumar, S., Dongworth, R. K., Aksentijević, D., Altamimi, T., Fridianto, K. T., Chinda, K., Hernández‐Reséndiz, S., Mahmood, M. U., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-23847-w · Cited by 13 · see citing works
NAD+ metabolism and retinal degeneration (Review)
Pîrvu, A. S., Andrei, A. M., Stănciulescu, E. C., Baniţă, I. M., Pisoschi, C. G., Jurja, S., & Ciuluvica, R. C. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10102 · Cited by 12 · see citing works
Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?
Wei, Z., Chai, H., Chen, Y., Cheng, Y., & Liu, X. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.08.006 · Cited by 12 · see citing works
Self-citationBiosynthesis of β-nicotinamide mononucleotide from glucose via a new pathway in Bacillus subtilis
Tan, Z., Yang, Y., Wu, Y., Yan, J., Zhang, B., Hou, Y., & Jia, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1405736 · Cited by 11 · see citing works
NAD in pathological cardiac remodeling: Metabolic regulation and beyond
Norambuena‐Soto, I., Deng, Y., Brenner, C., Lavandero, S., & Wang, Z. V. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167038 · Cited by 9 · see citing works
Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
Tong, W.-H., Ollivierre, H., Noguchi, A. C., Ghosh, M. C., Springer, D., & Rouault, T. A. (2021) · Heliyon · doi:10.1016/j.heliyon.2022.e10371 · Cited by 8 · see citing works
Metabolomics analysis reveals dysregulation in one carbon metabolism in Friedreich Ataxia
O’Connell, T. M., Logsdon, D. L., & Payne, R. M. (2022) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2022.06.002 · Cited by 9 · see citing works
Self-citationAlashti, F. A., & Goliaei, B. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177651 · Cited by 8 · see citing works
Expanding the landscape of lysine acetylation stoichiometry and clinical impact
Encarnación‐Guevara, S., & Gil, J. (2025) · Journal of Proteomics · doi:10.1016/j.jprot.2025.105522 · Cited by 10 · see citing works
Kourek, C., Briasoulis, Α., Papamichail, A., Xanthopoulos, A. V., Tsougos, E., Farmakis, D. T., & PARASKEVAIDIS, I. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063113 · Cited by 11 · see citing works
Yang, S., Jing, S., Wang, S., & Jia, F. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1303645 · Cited by 7 · see citing works
Zhang, Y., Long, X., Yao, B.-F., Tian, J., Peng, J., & Luo, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.09.026 · Cited by 6 · see citing works
Liu, S., Deshmukh, V., Wang, F., Liang, J., Cusick, J., Li, X., & Martin, J. F. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.02.014 · Cited by 6 · see citing works
NAD+ enhancers as therapeutic agents in the cardiorenal axis
Marin-Blazquez, M., Rovira, J., Ramírez-Bajo, M. J., Perez, R. Z., & Rabadán-Ros, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01903-4 · Cited by 6 · see citing works
Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine
Mongelli, A., & Gaetano, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103080 · Cited by 6 · see citing works
- Authors
- Martin, A. S., Abraham, D. M., Hershberger, K. A., Bhatt, D. P., Mao, L., Cui, H., Liu, J., Liu, X., Muehlbauer, M. J., Grimsrud, P. A., Locasale, J. W., Payne, R. M., & Hirschey, M. D.
- Affiliations
- Duke University (US)
- Department of Pharmacology and Cancer Biology,
- Indiana University Indianapolis (US)
- ORCID
- Venue
- JCI Insight
- Published
- 2017-07-20
- Volume
- 2
- Issue
- 14
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC5518566
- OpenAlex
- W2736952832
- Cited by
- 128
- References
- 69
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 16 · 2023: 17 · 2022: 22 · 2021: 18 · 2020: 11 · 2019: 11 · 2018: 15 · 2017: 3
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Friedreich's Ataxia Research Alliance
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA022146)
- National Heart, Lung, and Blood Institute (F31HL123275, K08HL125905)
- National Cancer Institute (R00CA168997)
- National Institute of General Medical Sciences (T32GM007184, T32GM007105)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK096493)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- nicotinamide mononucleotide, SIRT3, cardiac function, myocardial energy metabolism, mitochondrial metabolism, NAD+ supplementation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
