Cited by 515Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

The impact of cellular metabolism on chromatin dynamics and epigenetics

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Reid, Michael A., Dai, Ziwei, Locasale, Jason W.·2017·Nature Cell Biology

Abstract

The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how metabolism can influence chromatin biology and epigenetics, discuss the functional roles of this interplay in developmental and cancer biology, and present future directions in this rapidly emerging area.

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  • The metabolic state constitutes a fundamental component of chromatin modification and genome regulation.

    “The metabolic state constitutes a fundamental component of chromatin modification and genome regulation97.”

    From Glutamine reliance in cell metabolism (2020) · cites this paper as [97]

  • By co-opting the production and localization of select TCA cycle metabolites, cells can modulate the activity of chromatin-modifying enzymes and exert control over gene expression and cell fate.

    “By co-opting the production and localization of select TCA cycle metabolites, cells can modulate the activity of chromatin-modifying enzymes and exert control over gene expression and cell fate (158, 159, 160).”

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  1. [1]Chandel NS Navigating metabolism Cold Spring Harbor Laboratory Press Cold Spring Harbor, New York 2015

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Authors
Reid, M. A., Dai, Z., & Locasale, J. W.
Affiliations
Duke University (US)
Corresponding author
Locasale, Jason W.
Venue
Nature Cell Biology
Published
2017-10-23
Volume
19
Issue
11
Pages
1298-1306
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2767172151
Cited by
515
References
163
Citations by year
2026: 49 · 2025: 49 · 2024: 51 · 2023: 48 · 2022: 80 · 2021: 68 · 2020: 83 · 2019: 55 · 2018: 30 · 2017: 1 · 2014: 1
FWCI
4.32
Type
journal article
Language
en
Open access
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (1s10od018164-01)
  • National Cancer Institute (R00CA168997, R01CA193256, P30CA014236)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
cellular metabolism, chromatin dynamics, epigenetics, chromatin regulation, nutrient availability, metabolic pathways, genome regulation, developmental biology, tumor biology
MeSH terms
Animals, Chromatin, Humans, Neoplasms, Epigenesis, Genetic, Metabolic Networks and Pathways, Epigenomics

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