The impact of cellular metabolism on chromatin dynamics and epigenetics
Open accessAbstract
The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how metabolism can influence chromatin biology and epigenetics, discuss the functional roles of this interplay in developmental and cancer biology, and present future directions in this rapidly emerging area.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The metabolic state constitutes a fundamental component of chromatin modification and genome regulation.
“The metabolic state constitutes a fundamental component of chromatin modification and genome regulation97.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [97]
By co-opting the production and localization of select TCA cycle metabolites, cells can modulate the activity of chromatin-modifying enzymes and exert control over gene expression and cell fate.
“By co-opting the production and localization of select TCA cycle metabolites, cells can modulate the activity of chromatin-modifying enzymes and exert control over gene expression and cell fate (158, 159, 160).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [158]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368 · see citing works
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · see citing works
<i>IDH1</i> and <i>IDH2</i> Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
The Warburg Effect: How Does it Benefit Cancer Cells?
Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.001 · Cited by 5,150 · see citing works
Self-citationCancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154 · see citing works
Dynamic RNA Modifications in Gene Expression Regulation
Roundtree, I. A., Evans, M., Pan, T., & He, C. (2017) · Cell · doi:10.1016/j.cell.2017.05.045 · Cited by 3,459 · see citing works
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chang, C.-H., Qiu, J., O’Sullivan, D., Buck, M. D., Noguchi, T., Curtis, J. D., Chen, Q., Gindin, M., Gubin, M. M., van der Windt, G. J. W., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.016 · Cited by 3,331 · see citing works
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082 · see citing works
Fundamentals of Cancer Metabolism
DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances · doi:10.1126/sciadv.1600200 · Cited by 3,013 · see citing works
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809 · see citing works
Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766 · see citing works
Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,542 · see citing works
Understanding the Intersections between Metabolism and Cancer Biology
Heiden, M. G. V., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,316 · see citing works
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241 · see citing works
Waddington, C. H. (2014) · doi:10.4324/9781315765471 · Cited by 2,153 · see citing works
Function and information content of DNA methylation
Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060 · see citing works
Tan, M., Luo, H., Lee, S., Jin, F., Yang, J. S., Montellier, E., Buchou, T., Cheng, Z., Rousseaux, S., Rajagopal, N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.008 · Cited by 1,902 · see citing works
An operational definition of epigenetics: Figure 1.Preprint
Berger, S. L., Kouzarides, T., Shiekhattar, R., & Shilatifard, A. (2009) · Genes & Development · doi:10.1101/gad.1787609 · Cited by 1,889 · see citing works
Hilton, I. B., D’Ippolito, A. M., Vockley, C. M., Thakore, P. I., Crawford, G. E., Reddy, T. E., & Gersbach, C. A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3199 · Cited by 1,879 · see citing works
PI3K pathway alterations in cancer: variations on a theme
Yuan, T. L., & Cantley, L. C. (2008) · Oncogene · doi:10.1038/onc.2008.245 · Cited by 1,845 · see citing works
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777 · see citing works
Serine, glycine and one-carbon units: cancer metabolism in full circle
Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,671 · see citing works
Self-citationTET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661 · see citing works
Phenotypic plasticity and the epigenetics of human disease
Feinberg, A. P. (2007) · Nature · doi:10.1038/nature05919 · Cited by 1,613 · see citing works
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ho, P.-C., Bihuniak, J. D., Macintyre, A. N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.-C., Cui, G., Micevic, G., Perales, J. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.012 · Cited by 1,462 · see citing works
Self-citationFueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Lewis, P. W., Müller, M. M., Koletsky, M. S., Cordero, F., Lin, S., Banaszynski, L. A., Garcia, B. A., Muir, T. W., Becher, O. J., & Allis, C. D. (2013) · Science · doi:10.1126/science.1232245 · Cited by 1,345 · see citing works
Parental olfactory experience influences behavior and neural structure in subsequent generations
Dias, B. G., & Ressler, K. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3594 · Cited by 1,338 · see citing works
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P. K., Kivioja, T., Dave, K., Zhong, F., et al. (2017) · Science · doi:10.1126/science.aaj2239 · Cited by 1,257 · see citing works
The Strategy of the Genes: A Discussion of Some Aspects of Theoretical Biology
(1958) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1958.tb86500.x · Cited by 1,244 · see citing works
Metabolic Instruction of Immunity
Buck, M. D., Sowell, R., Kaech, S. M., & Pearce, E. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.004 · Cited by 1,233 · see citing works
Editing DNA Methylation in the Mammalian Genome
Liu, X. S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R. A., & Jaenisch, R. (2016) · Cell · doi:10.1016/j.cell.2016.08.056 · Cited by 1,224 · see citing works
Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., et al. (2012) · Genes & Development · doi:10.1101/gad.191056.112 · Cited by 1,188 · see citing works
Carone, B. R., Fauquier, L., Habib, N., Shea, J. M., Hart, C. E., Li, R., Bock, C., Li, C., Gu, H., Zamore, P. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.12.008 · Cited by 1,157 · see citing works
Metabolic regulation of gene expression through histone acylations
Sabari, B. R., Zhang, D., Allis, C. D., & Zhao, Y. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.140 · Cited by 1,134 · see citing works
Canalization of Development and Genetic Assimilation of Acquired Characters
Waddington, C. H. (1959) · Nature · doi:10.1038/1831654a0 · Cited by 1,093 · see citing works
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
Whetstine, J. R., Nottke, A. C., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G., Colaiácovo, M. P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.028 · Cited by 1,046 · see citing works
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Chowdhury, R., Yeoh, K. K., Tian, Y., Hillringhaus, L., Bagg, E. A., Rose, N. R., Leung, I. K. H., Li, X. S., Woon, E. C. Y., Yang, M., et al. (2011) · The EMBO Reports · doi:10.1038/embor.2011.43 · Cited by 1,035 · see citing works
Histone core modifications regulating nucleosome structure and dynamics
Tessarz, P., & Kouzarides, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3890 · Cited by 1,018 · see citing works
Metabolic requirements for the maintenance of self-renewing stem cells
Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3772 · Cited by 1,014 · see citing works
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D., & Thompson, C. B. (2015) · Nature · doi:10.1038/nature13981 · Cited by 1,007 · see citing works
Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human
Takashima, Y., Guo, G., Loos, R., Nichols, J., Ficz, G., Krueger, F., Oxley, D., Santos, F., Clarke, J., Mansfield, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.029 · Cited by 980 · see citing works
Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.035 · Cited by 950 · see citing works
Influence of Metabolism on Epigenetics and Disease
Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920 · see citing works
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Feinberg, A. P., Koldobskiy, M. A., & Göndör, A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.13 · Cited by 878 · see citing works
50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
Verdin, E. M., & Ott, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3931 · Cited by 876 · see citing works
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
Blaschke, K., Ebata, K. T., Karimi, M. M., Zepeda-Martínez, J. A., Goyal, P., Mahapatra, S., Tam, A., Laird, D. J., Hirst, M., Rao, A., et al. (2013) · Nature · doi:10.1038/nature12362 · Cited by 865 · see citing works
Disease modeling in stem cell-derived 3D organoid systems
Dutta, D., Heo, I., & Clevers, H. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.007 · Cited by 838 · see citing works
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
Peng, M., Yin, N., Chhangawala, S., Xu, K., Leslie, C. S., & Li, M. O. (2016) · Science · doi:10.1126/science.aaf6284 · Cited by 787 · see citing works
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Liu, X., Wang, C., Liu, W., Li, J., Li, C., Kou, X., Chen, J., Zhao, Y., Gao, H., Wang, H., et al. (2016) · Nature · doi:10.1038/nature19362 · Cited by 746 · see citing works
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie, Z., Zhang, D., Chung, D., Tang, Z., Huang, H., Dai, L., Qi, S., Li, J., Colak, G., Chen, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.036 · Cited by 744 · see citing works
Intragenic DNA methylation prevents spurious transcription initiation
Neri, F., Rapelli, S., Krepelova, A., Incarnato, D., Parlato, C., Basile, G., Maldotti, M., Anselmi, F., & Oliviero, S. (2017) · Nature · doi:10.1038/nature21373 · Cited by 739 · see citing works
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 729 · see citing works
Self-citationTransformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Koivunen, P., Lee, S., Duncan, C. G., Lopez, G., Lu, G., Ramkissoon, S., Losman, J. A., Joensuu, P., Bergmann, U., Gross, S., et al. (2012) · Nature · doi:10.1038/nature10898 · Cited by 727 · see citing works
Interpreting the language of histone and DNA modifications
Rothbart, S. B., & Strahl, B. D. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.03.001 · Cited by 721 · see citing works
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
Mentch, S. J., Mehrmohamadi, M., Huang, L., Liu, X., Gupta, D., Mattocks, D. A. L., Padilla, P. G., Ables, G. P., Bamman, M. M., Thalacker‐Mercer, A. E., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.024 · Cited by 706 · see citing works
Self-citationCai, L., Sutter, B. M., Li, B., & Tu, B. P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.004 · Cited by 701 · see citing works
Kryukov, G. V., Wilson, F. H., Ruth, J. R., Paulk, J., Tsherniak, A., Marlow, S. E., Vazquez, F., Weir, B. A., Fitzgerald, M. E., Tanaka, M., et al. (2016) · Science · doi:10.1126/science.aad5214 · Cited by 688 · see citing works
Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M., Levy, G., Barasch, D., Nemirovski, A., Shen-Orr, S., Laevsky, I., Amit, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.002 · Cited by 666 · see citing works
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works
Influence of Threonine Metabolism on <i>S</i> -Adenosylmethionine and Histone Methylation
Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., et al. (2013) · Science · doi:10.1126/science.1226603 · Cited by 638 · see citing works
Self-citationBroad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Dahl, J. A., Jung, I., Aanes, H., Greggains, G. D., Manaf, A., Lerdrup, M., Li, G., Kuan, S., Li, B., Lee, A. Y., et al. (2016) · Nature · doi:10.1038/nature19360 · Cited by 628 · see citing works
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y.-L., Peng, X., Jia, M., Wu, X., Zhang, Y., Xu, Q.-H., et al. (2016) · Nature · doi:10.1038/nature19361 · Cited by 627 · see citing works
Cantor, J. R., Abu-Remaileh, M., Kanarek, N., Freinkman, E., Gao, X., Louissaint, A., Lewis, C. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.03.023 · Cited by 610 · see citing works
In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism
Radford, E. J., Ito, M., Shi, H., Corish, J. A., Yamazawa, K., ISGANAITIS, E. M., Seisenberger, S., Hore, T. A., Reik, W., Erkek, S., et al. (2014) · Science · doi:10.1126/science.1255903 · Cited by 609 · see citing works
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Chin, R., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., et al. (2014) · Nature · doi:10.1038/nature13264 · Cited by 608 · see citing works
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Mavrakis, K. J., McDonald, E. R., Schlabach, M. R., Billy, E., Hoffman, G. R., deWeck, A., Ruddy, D. A., Venkatesan, K., Yu, J., McAllister, G., et al. (2016) · Science · doi:10.1126/science.aad5944 · Cited by 607 · see citing works
Modulating the therapeutic response of tumours to dietary serine and glycine starvation
Maddocks, O. D. K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J. F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., et al. (2017) · Nature · doi:10.1038/nature22056 · Cited by 603 · see citing works
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Sciacovelli, M., Gonçalves, E., Johnson, T. I., Zecchini, V. R., da Costa, A. S. H., Gaude, E., Drubbel, A. V., Theobald, S. J., Abbo, S. R., Tran, M. G. B., et al. (2016) · Nature · doi:10.1038/nature19353 · Cited by 584 · see citing works
Ryall, J. G., Dell’Orso, S., Derfoul, A., Juan, A., Zare, H., Feng, X., Clermont, D., Koulnis, M., Gutierrez-Cruz, G., Fulco, M., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.004 · Cited by 575 · see citing works
What a difference a hydroxyl makes: mutant IDH, (<i>R</i>)-2-hydroxyglutarate, and cancer
Losman, J.-A., & Kaelin, W. G. (2013) · Genes & Development · doi:10.1101/gad.217406.113 · Cited by 570 · see citing works
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563 · see citing works
Tardito, S., Oudin, A., Ahmed, S. U., Fack, F., Keunen, O., Zheng, L., Miletic, H., Sakariassen, P. Ø., Weinstock, A., Wagner, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3272 · Cited by 557 · see citing works
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature · doi:10.1038/nature23876 · Cited by 545 · see citing works
H3K4me3 breadth is linked to cell identity and transcriptional consistency
Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.027 · Cited by 536 · see citing works
A two-way street: reciprocal regulation of metabolism and signalling
Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3305 · Cited by 528 · see citing works
Epigenetic balance of gene expression by Polycomb and COMPASS families
Piunti, A., & Shilatifard, A. (2016) · Science · doi:10.1126/science.aad9780 · Cited by 524 · see citing works
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Etchegaray, J., & Mostoslavsky, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.029 · Cited by 521 · see citing works
Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells
Shiraki, N., Shiraki, Y., Tsuyama, T., Obata, F., Miura, M., Nagae, G., Aburatani, H., Kume, K., Endo, F., & Kume, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.017 · Cited by 514 · see citing works
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature · doi:10.1038/nature22405 · Cited by 514 · see citing works
McDonald, O. G., Li, X., Saunders, T., Tryggvadottir, R., Mentch, S. J., Warmoes, M. O., Word, A. E., Carrer, A., Salz, T. H., Natsume, S., et al. (2017) · Nature Genetics · doi:10.1038/ng.3753 · Cited by 494 · see citing works
Self-citationOne‐carbon metabolism and epigenetics: understanding the specificity
Mentch, S. J., & Locasale, J. W. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12956 · Cited by 481 · see citing works
Self-citationMatoba, S., Liu, Y., Lu, F., Iwabuchi, K. A., Shen, L., Inoue, A., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2014.09.055 · Cited by 472 · see citing works
Yen, K., Travins, J., Wang, F., David, M. D., Artin, E., Straley, K., Padyana, A., Gross, S., DeLaBarre, B., Tobin, E., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1034 · Cited by 471 · see citing works
Transgenerational transmission of environmental information in <i>C. elegans</i>
Klosin, A., Casas, E., Hidalgo-Carcedo, C., Vavouri, T., & Lehner, B. (2017) · Science · doi:10.1126/science.aah6412 · Cited by 456 · see citing works
Liu, X., & Locasale, J. W. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.01.004 · Cited by 453 · see citing works
Self-citationMetabolic flux and the regulation of mammalian cell growth
Locasale, J. W., & Cantley, L. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.014 · Cited by 449 · see citing works
Self-citationTransition states and cell fate decisions in epigenetic landscapes
Moris, N., Pina, C., & Arias, A. M. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.98 · Cited by 438 · see citing works
Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals
Wei, Y., Yang, C.-R., Wei, Y.-P., Zhao, Z.-A., Hou, Y., Schatten, H., & Sun, Q.-Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321195111 · Cited by 423 · see citing works
Sperber, H., Mathieu, J., Wang, Y., Ferreccio, A., Hesson, J., Xu, Z., Fischer, K. A., Devi, A., Detraux, D., Gu, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3264 · Cited by 421 · see citing works
Metabolic control of epigenetics in cancer
Kinnaird, A. S., Zhao, S., Wellen, K. E., & Michelakis, E. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.82 · Cited by 419 · see citing works
Minor, E. A., Court, B. L., Young, J. I., & Wang, G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.464800 · Cited by 413 · see citing works
Belenky, P., Racette, F. G., Bogan, K. L., McClure, J. M., Smith, J. S., & Brenner, C. (2007) · Cell · doi:10.1016/j.cell.2007.03.024 · Cited by 411 · see citing works
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.005 · Cited by 406 · see citing works
Dorighi, K. M., Swigut, T., Henriques, T., Bhanu, N. V., Scruggs, B. S., Nady, N., Still, C. D., Garcia, B. A., Adelman, K., & Wysocka, J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.018 · Cited by 403 · see citing works
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Lü, C., Jain, S. U., Hoelper, D., Béchet, D., Molden, R. C., Ran, L., Murphy, D. A., Venneti, S., Hameed, M., Pawel, B., et al. (2016) · Science · doi:10.1126/science.aac7272 · Cited by 392 · see citing works
Chen, K., Chen, Z., Wu, D., Zhang, L., Lin, X., Su, J., Rodriguez, B., Xi, Y., Xia, Z., Chen, X., et al. (2015) · Nature Genetics · doi:10.1038/ng.3385 · Cited by 373 · see citing works
Pan, M., Reid, M. A., Lowman, X. H., Kulkarni, R. P., Tran, T. Q., Liu, X., Yang, Y., Hernandez-Davies, J. E., Rosales, K. K., Li, H., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3410 · Cited by 368 · see citing works
Self-citationDependence of Mouse Embryonic Stem Cells on Threonine Catabolism
Wang, J., Alexander, P. B., Wu, L. C., Hammer, R. E., Cleaver, O. B., & McKnight, S. L. (2009) · Science · doi:10.1126/science.1173288 · Cited by 365 · see citing works
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Kottakis, F., Nicolay, B. N., Roumane, A., Karnik, R., Gu, H., Nagle, J. M., Boukhali, M., Hayward, M. C., Li, Y. Y., Chen, T., et al. (2016) · Nature · doi:10.1038/nature20132 · Cited by 348 · see citing works
Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Chandel, N. S., Jasper, H., Ho, T. T., & Passegué, E. (2016) · Nature Cell Biology · doi:10.1038/ncb3385 · Cited by 326 · see citing works
Metabolic Reprogramming of Stem Cell Epigenetics
Ryall, J. G., Cliff, T. S., Dalton, S., & Sartorelli, V. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.11.012 · Cited by 325 · see citing works
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
Schell, J. C., Wisidagama, D. R., Bensard, C., Zhao, H., Wei, P., Tanner, J., Flores, A., Mohlman, J., Sorensen, L. K., Earl, C. S., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3593 · Cited by 322 · see citing works
Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases
Wagner, G. R., & Hirschey, M. D. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.027 · Cited by 319 · see citing works
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan
Han, S., Schroeder, E. A., Silva-García, C. G., Hebestreit, K., Mair, W. B., & Brunet, A. (2017) · Nature · doi:10.1038/nature21686 · Cited by 314 · see citing works
The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Ansó, E., Weinberg, S. E., Diebold, L. P., Thompson, B. J., Malinge, S., Schumacker, P. T., Liu, X., Zhang, Y., Shao, Z., Steadman, M., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3529 · Cited by 310 · see citing works
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
Laukka, T., Mariani, C. J., Ihantola, T., Cao, J. Z., Hokkanen, J., Kaelin, W. G., Godley, L. A., & Koivunen, P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.688762 · Cited by 307 · see citing works
Lactate dehydrogenase activity drives hair follicle stem cell activation
Flores, A., Schell, J., Krall, A. S., Jelinek, D., Miranda, M., Grigorian, M., Braas, D., White, A. C., Zhou, J. L., Graham, N. A., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3575 · Cited by 301 · see citing works
Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
Phan, A. T., Goldrath, A. W., & Glass, C. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.016 · Cited by 291 · see citing works
From profiles to function in epigenomics
Stricker, S. H., Köferle, A., & Beck, S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.138 · Cited by 290 · see citing works
α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
TeSlaa, T., Chaikovsky, A. C., Lipchina, I., Escobar, S. L., Hochedlinger, K., Huang, J., Graeber, T. G., Braas, D., & Teitell, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.002 · Cited by 287 · see citing works
Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State
Gu, W., Gaeta, X., Sahakyan, A., Chan, A. B., Hong, C. S., Kim, R., Braas, D., Plath, K., Lowry, W. E., & Christofk, H. R. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.008 · Cited by 275 · see citing works
Advances in the profiling of DNA modifications: cytosine methylation and beyond
Plongthongkum, N., Diep, D. H., & Zhang, K. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3772 · Cited by 259 · see citing works
Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases
Rose, N. R., Ng, S. S., Mecinović, J., Liénard, B. M. R., Bello, S. H., Sun, Z., McDonough, M. A., Oppermann, U. C. T., & Schofield, C. J. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800936s · Cited by 255 · see citing works
Histone H3 globular domain acetylation identifies a new class of enhancers
Pradeepa, M. M., Grimes, G. R., Kumar, Y., Olley, G., Taylor, G. C. A., Schneider, R., & Bickmore, W. A. (2016) · Nature Genetics · doi:10.1038/ng.3550 · Cited by 240 · see citing works
Regulated Noise in the Epigenetic Landscape of Development and Disease
Pujadas, E., & Feinberg, A. P. (2012) · Cell · doi:10.1016/j.cell.2012.02.045 · Cited by 234 · see citing works
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies
Ladewig, J., Koch, P., & Brüstle, O. (2013) · Nature reviews. Molecular cell biology · doi:10.1038/nrm3543 · Cited by 233 · see citing works
Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers
Liu, X., Romero, I. L., Litchfield, L. M., Lengyel, E. R., & Locasale, J. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.005 · Cited by 228 · see citing works
Self-citationMetabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption
Romano, K. A., Martinez-del Campo, A., Kasahara, K., Chittim, C. L., Vivas, E. I., Amador-Noguez, D., Balskus, E. P., & Rey, F. E. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.021 · Cited by 224 · see citing works
Melnyk, S., Pogribna, M., Pogribny, I. P., Yi, P., & James, S. J. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.2.265 · Cited by 221 · see citing works
Causal role for inheritance of H3K27me3 in maintaining the OFF state of a <i>Drosophila</i> HOX gene
Coleman, R. T., & Struhl, G. (2017) · Science · doi:10.1126/science.aai8236 · Cited by 221 · see citing works
Borra, M. T., Langer, M. R., Slama, J. T., & Denu, J. M. (2004) · Biochemistry · doi:10.1021/bi049592e · Cited by 214 · see citing works
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Jiang, Y., Qian, X., Shen, J., Wang, Y., Li, X., Liu, R., Xia, Y., Chen, Q., Peng, G., Lin, S.-Y., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3209 · Cited by 208 · see citing works
Oginuma, M., Moncuquet, P., Xiong, F., Karoly, E. D., Chal, J., Guevorkian, K., & Pourquié, O. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.001 · Cited by 202 · see citing works
Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation
Taya, Y., Ota, Y., Wilkinson, A. C., Kanazawa, A., Watarai, H., Kasai, M., Nakauchi, H., & Yamazaki, S. (2016) · Science · doi:10.1126/science.aag3145 · Cited by 189 · see citing works
Metabolic differentiation in the embryonic retina
Agathocleous, M., Love, N. K., Randlett, O., Harris, J. J., Liu, J., Murray, A. J., & Harris, W. A. (2012) · Nature Cell Biology · doi:10.1038/ncb2531 · Cited by 182 · see citing works
Yamada, K., Hara, N., Shibata, T., Osago, H., & Tsuchiya, M. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.02.017 · Cited by 154 · see citing works
Cellular Metabolism and Induced Pluripotency
Wu, J., Ocampo, A., & Belmonte, J. C. I. (2016) · Cell · doi:10.1016/j.cell.2016.08.008 · Cited by 152 · see citing works
The rate of glycolysis quantitatively mediates specific histone acetylation sites
Cluntun, A. A., Huang, H., Dai, L., Liu, X., Zhao, Y., & Locasale, J. W. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0135-3 · Cited by 148 · see citing works
Self-citations-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways
Ding, W., Smulan, L. J., Hou, N. S., Taubert, S., Watts, J. L., & Walker, A. K. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.013 · Cited by 130 · see citing works
Hörmanseder, E., Simeone, A., Allen, G. E., Bradshaw, C. R., Figlmüller, M., Gurdon, J. B., & Jullien, J. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.003 · Cited by 120 · see citing works
p300/CBP-associated Factor Histone Acetyltransferase Processing of a Peptide Substrate
Lau, O. D., Courtney, A. D., Vassilev, A. P., Marzilli, L. A., Cotter, R. J., Nakatani, Y., & Cole, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003219200 · Cited by 119 · see citing works
Functional interdependence of BRD4 and DOT1L in MLL leukemia
Gilan, O., Lam, E. Y. N., Becher, I., Lugo, D., Cannizzaro, E., Joberty, G., Ward, A., Wiese, M., Fong, C. Y., Ftouni, S., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3249 · Cited by 114 · see citing works
Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds
Horton, J. R., Liu, X., Gale, M., Wu, L., Shanks, J. R., Zhang, X., Webber, P. J., Bell, J. S. K., Kales, S. C., Mott, B. T., et al. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.06.006 · Cited by 103 · see citing works
Chisolm, D. A., Savic, D., Moore, A. J., Ballesteros‐Tato, A., León, B., Crossman, D. K., Murre, C., Myers, R., & Weinmann, A. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.015 · Cited by 103 · see citing works
Epigenetics at the Crossroads of Genes and the Environment
Feinberg, A. P., & Fallin, M. D. (2015) · JAMA · doi:10.1001/jama.2015.10414 · Cited by 100 · see citing works
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
Wang, T., Yu, Q., Li, J., Hu, B., Zhao, Q., Ma, C., Huang, W., Zhuo, L., Fang, H., Liao, L., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3562 · Cited by 100 · see citing works
Kinetic Mechanism of Human Histone Acetyltransferase P/CAF
Tanner, K. G., Langer, M. R., & Denu, J. M. (2000) · Biochemistry · doi:10.1021/bi001272h · Cited by 98 · see citing works
DNA-methylase from regenerating rat liver: purification and characterisation
Simon, D., Grunert, F., van Acken, U., Dörining, H. P., & Kröger, H. (1978) · Nucleic Acids Research · doi:10.1093/nar/5.6.2153 · Cited by 97 · see citing works
Hardikar, A. A., Satoor, S. N., Karandikar, M. S., Joglekar, M. V., Puranik, A. S., Wong, W. K. M., Kumar, S., Limaye, A. S., Bhat, D., Januszewski, A. S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.008 · Cited by 92 · see citing works
Understanding metabolism with flux analysis: From theory to application
Dai, Z., & Locasale, J. W. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.09.005 · Cited by 90 · see citing works
Self-citationGuan, X., Lin, P. C., Knoll, E., & Chakrabarti, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107729 · Cited by 82 · see citing works
Intracellular alpha-ketoglutarate controls the efficacy of renal organic anion transport
Pritchard, J. B. (1995) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10636-8 · Cited by 78 · see citing works
Oden, K. L., & Clarke, S. G. (1983) · Biochemistry · doi:10.1021/bi00281a030 · Cited by 77 · see citing works
Rathert, P., Zhang, X., Freund, C., Cheng, X., & Jeltsch, A. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.11.013 · Cited by 71 · see citing works
Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues?
Rajagopal, J., & Stanger, B. Z. (2016) · Developmental Cell · doi:10.1016/j.devcel.2015.12.021 · Cited by 67 · see citing works
Cascella, B., & Mirica, L. M. (2012) · Biochemistry · doi:10.1021/bi3012466 · Cited by 62 · see citing works
Phage T4 DNA [N]-adenine6Methyltransferase. OVEREXPRESSION, PURIFICATION, AND CHARACTERIZATION
Kossykh, V. G., Schlagman, S. L., & Hattman, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14389 · Cited by 59 · see citing works
Metabolic interactions with cancer epigenetics
Gao, X., Reid, M. A., Kong, M., & Locasale, J. W. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.09.001 · Cited by 54 · see citing works
Self-citationShen, J., Khan, N. I., Lewis, L. D., Armand, R., Grinberg, O. Y., Demidenko, E., & Swartz, H. M. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74944-3 · Cited by 53 · see citing works
Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism
Mehrmohamadi, M., Mentch, L., Clark, A. G., & Locasale, J. W. (2016) · Nature Communications · doi:10.1038/ncomms13666 · Cited by 45 · see citing works
Self-citationAcetylation of Nucleosomal Histones in vitro
BÖHM, J., Schlaeger, E., & Knippers, R. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb07212.x · Cited by 32 · see citing works
Substrate and product inhibition initial rate kinetics of histone acetyltransferase
Wiktorowicz, J. E., Campos, K. L., & Bonner, J. (1981) · Biochemistry · doi:10.1021/bi00509a009 · Cited by 23 · see citing works
Cohen, H. M., Griffiths, A. D., Tawfik, D. S., & Loakes, D. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b415446k · Cited by 21 · see citing works
Huang, Z., Cai, L., & Tu, B. P. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.05.004 · Cited by 18 · see citing works
Tuck, M. T., FAROOQUI, J. Z., & Paik, W. K. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88895-0 · Cited by 18 · see citing works
Kinetic Mechanism of Human Histone Acetyltransferase P/CAF
Tanner, K. G., Langer, M. R., & Denu, J. M. (2000) · Biochemistry · doi:10.1021/bi005121q · Cited by 17 · see citing works
Lobet, Y., Lhoest, J., & Colson, C. (1989) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(89)90191-x · Cited by 16 · see citing works
del Gaudio, R., Giaimo, R. D., Potenza, N., Branno, M., Aniello, F., & Geraci, G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01379-4 · Cited by 10 · see citing works
An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation
Balbach, S. T., & Orkin, S. H. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0564 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [1]Chandel NS Navigating metabolism Cold Spring Harbor Laboratory Press Cold Spring Harbor, New York 2015
Cited by
Sorted by citations
Glutamine reliance in cell metabolism
Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works
Modulation of cellular processes by histone and non-histone protein acetylation
Shvedunova, M., & Akhtar, A. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00441-y · Cited by 975 · see citing works
Metabolism of immune cells in cancer
Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877 · see citing works
Metabolic reprogramming and epigenetic modifications on the path to cancer
Sun, L., Zhang, H., & Gao, P. (2021) · Protein & Cell · doi:10.1007/s13238-021-00846-7 · Cited by 796 · see citing works
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Johnson, M. O., Wolf, M. M., Madden, M. Z., Andrejeva, G., Sugiura, A., Contreras, D. C., Maseda, D., Liberti, M. V., Paz, K. G., Kishton, R. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.001 · Cited by 702 · see citing works
Self-citationMetabolomics in cancer research and emerging applications in clinical oncology
Schmidt, D. R., Patel, R., Kirsch, D. G., Lewis, C. A., Heiden, M. G. V., & Locasale, J. W. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21670 · Cited by 652 · see citing works
Self-citationGlycolysis – a key player in the inflammatory response
Soto‐Heredero, G., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · FEBS Journal · doi:10.1111/febs.15327 · Cited by 645 · see citing works
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works
The evolving metabolic landscape of chromatin biology and epigenetics
Dai, Z., Ramesh, V., & Locasale, J. W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0270-8 · Cited by 494 · see citing works
Self-citationIrizarry-Caro, R. A., McDaniel, M. M., Overcast, G. R., Jain, V. G., Troutman, T. D., & Pasare, C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009778117 · Cited by 465 · see citing works
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment
Kim, S. K., & Cho, S. W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.868695 · Cited by 473 · see citing works
The language of chromatin modification in human cancers
Zhao, S., Allis, C. D., & Wang, G. G. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00357-x · Cited by 406 · see citing works
Sex differences in cancer mechanisms
Rubin, J. B., Lagas, J. S., Broestl, L., Sponagel, J., Rockwell, N., Rhee, G., Rosen, S. F., Chen, S., Klein, R. S., Imoukhuede, P. I., et al. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00291-x · Cited by 370 · see citing works
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
Vetrie, D. L. P., Helgason, G. V., & Copland, M. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-019-0230-9 · Cited by 351 · see citing works
Metabolic signaling in T cells
Shyer, J. A., Flavell, R. A., & Bailis, W. (2020) · Cell Research · doi:10.1038/s41422-020-0379-5 · Cited by 334 · see citing works
Finley, L. W. S. (2023) · Cell · doi:10.1016/j.cell.2023.01.038 · Cited by 331 · see citing works
N6-methyladenosine regulates glycolysis of cancer cells through PDK4
Li, Z., Peng, Y., Li, J., Chen, Z., Chen, F., Tu, J., Lin, S., & Wang, H. (2020) · Nature Communications · doi:10.1038/s41467-020-16306-5 · Cited by 325 · see citing works
Metabolic signatures of cancer cells and stem cells
Intlekofer, A. M., & Finley, L. W. S. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0032-0 · Cited by 322 · see citing works
Metabolic interventions in the immune response to cancer
O’Sullivan, D., Sanin, D. E., Pearce, E. J., & Pearce, E. L. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0140-9 · Cited by 314 · see citing works
Chemical and Biochemical Perspectives of Protein Lysine Methylation
Luo, M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00008 · Cited by 288 · see citing works
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus, P., Lecoutre, S., Dollet, L., Wiel, C., Sulen, A., Gao, H., Tavira, B., Laurencikiene, J., Rooyackers, O., Checa, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.019 · Cited by 254 · see citing works
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
Liang, R. H.-S., Arif, T., Kalmykova, S., Kasianov, A. S., Miao, L., Menon, V., Qiu, J., Bernitz, J. M., Moore, K. A., Lin, F., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.013 · Cited by 248 · see citing works
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
Beacon, T. H., Delcuve, G. P., Lopez, C. L., Nardocci, G., Kovalchuk, I., van Wijnen, A. J., & Davie, J. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01126-1 · Cited by 252 · see citing works
DNA Damage, Repair, and Cancer Metabolism
Turgeon, M., Perry, N. J. S., & Poulogiannis, G. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00015 · Cited by 241 · see citing works
Metabolic regulation of chromatin modifications and gene expression
Schvartzman, J. M., Thompson, C. B., & Finley, L. W. S. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803061 · Cited by 233 · see citing works
Hematopoietic Stem Cell Metabolism during Development and Aging
Nakamura‐Ishizu, A., Ito, K., & Suda, T. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.029 · Cited by 232 · see citing works
Serine, glycine and one‑carbon metabolism in cancer (Review)
Pan, S., Fan, M., Liu, Z., Li, X., & Wang, H. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5158 · Cited by 227 · see citing works
Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症:英文版 · doi:10.1002/cac2.12374 · Cited by 206 · see citing works
Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia
Marı́n, R., Chiarello, D. I., Abad, C., Rojas, D., Toledo, F., & Sobrevía, L. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165961 · Cited by 190 · see citing works
Metabolic Signaling to the Nucleus in Cancer
Campbell, S. L., & Wellen, K. E. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.015 · Cited by 182 · see citing works
Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis
Yamashita, M., Dellorusso, P. V., Olson, O. C., & Passegue, E. A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0260-3 · Cited by 182 · see citing works
The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review
Deng, Q., Luo, Y., Chang, C., Wu, H., Ding, Y. P., & Xiao, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00856 · Cited by 159 · see citing works
A guide to interrogating immunometabolism
Voss, K., Hong, H. S., Bader, J. E., Sugiura, A., Lyssiotis, C. A., & Rathmell, J. C. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00529-8 · Cited by 162 · see citing works
Histone Modifications and their Role in Epigenetics of Cancer
Zaib, S., Rana, N., & Khan, I. A. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666211108105214 · Cited by 153 · see citing works
Ramos‐Ibeas, P., Sang, F., Zhu, Q., Tang, W. W. C., Withey, S., Klisch, D., Wood, L., Loose, M., Surani, M. A., & Alberio, R. (2019) · Nature Communications · doi:10.1038/s41467-019-08387-8 · Cited by 142 · see citing works
Safi-Stibler, S., & Gabory, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.09.008 · Cited by 127 · see citing works
The Multifaceted Roles of Proline in Cell Behavior
Patriarca, E. J., Cermola, F., D’Aniello, C., Fico, A., Guardiola, O., Cesare, D. D., & Minchiotti, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728576 · Cited by 139 · see citing works
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension
Chen, J., Zhang, M., Liu, Y., Zhao, S., Wang, Y., Wang, M., Niu, W., Jin, F., & Li, Z. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac073 · Cited by 136 · see citing works
Gene Regulation and Cellular Metabolism: An Essential Partnership
Carthew, R. W. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.09.018 · Cited by 133 · see citing works
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
Dai, Z., Mentch, S. J., Gao, X., Nichenametla, S. N., & Locasale, J. W. (2018) · Nature Communications · doi:10.1038/s41467-018-04426-y · Cited by 132 · see citing works
Self-citationCancer Stem Cells: From Historical Roots to a New Perspective
Capp, J. (2019) · Journal of Oncology · doi:10.1155/2019/5189232 · Cited by 130 · see citing works
Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis
de Oliveira, P. G., Farinon, M., Sánchez‐López, E., Miyamoto, S., & Gumá, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01743 · Cited by 131 · see citing works
Glutamine Metabolism Controls Chondrocyte Identity and Function
Stegen, S., Rinaldi, G., Loopmans, S., Stockmans, I., Moermans, K., Thienpont, B., Fendt, S., Carmeliet, P., & Carmeliet, G. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.05.001 · Cited by 130 · see citing works
Nuclear metabolism and the regulation of the epigenome
Boon, R., da Silveira, G. G., & Mostoslavsky, R. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00285-4 · Cited by 126 · see citing works
The complexity of the serine glycine one-carbon pathway in cancer
Reina‐Campos, M., Díaz-Meco, M. T., & Moscat, J. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201907022 · Cited by 123 · see citing works
Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
Miranda‐Gonçalves, V., Lameirinhas, A., Henrique, R., & Jerónimo, C. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00427 · Cited by 122 · see citing works
Crosstalk between metabolism and epigenetics during macrophage polarization
Zhang, K., & Jagannath, C. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00575-9 · Cited by 128 · see citing works
Yang, W., Wang, P., Cao, P., Wang, S., Yang, Y., Huimin, S., & Nashun, B. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00431-6 · Cited by 118 · see citing works
Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells
Hu, Z., Tan, D. E. K., Chia, G., Tan, H., Leong, H. F., Chen, B. J., Lau, M. S., Tan, K. Y. S., Bi, X., Yang, D., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0453-8 · Cited by 115 · see citing works
Regulatory roles of mitochondria and metabolism in neurogenesis
Iwata, R., & Vanderhaeghen, P. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.05.003 · Cited by 114 · see citing works
Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer
Huo, M., Zhang, J., Huang, W., & Wang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.793428 · Cited by 114 · see citing works
Reciprocal regulation of cellular mechanics and metabolism
Evers, T. M. J., Holt, L. J., Alberti, S., & Mashaghi, A. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00384-w · Cited by 103 · see citing works
Li, J., Zhang, J., Hou, W., Yang, X., Liu, X., Zhang, Y., Gao, M., Zong, M., Dong, Z., Liu, Z., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00440-z · Cited by 107 · see citing works
Condelli, V., Crispo, F., Pietrafesa, M., Lettini, G., Matassa, D. S., Esposito, F., Landriscina, M., & Maddalena, F. (2019) · Cells · doi:10.3390/cells8060532 · Cited by 105 · see citing works
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells
Püschel, F., Favaro, F., Redondo-Pedraza, J., Lucendo, E., Iurlaro, R., Marchetti, S., Majem, B., Eldering, E., Nadal, E., Ricci, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913707117 · Cited by 99 · see citing works
Fallet, M., Montagnani, C., Petton, B., Dantan, L., de Lorgeril, J., Comarmond, S., Chaparro, C., Toulza, È., Boitard, S., Escoubas, J.-M., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01280-5 · Cited by 102 · see citing works
Wu, H., Huang, H., & Zhao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1211221 · Cited by 96 · see citing works
G6PD: A hub for metabolic reprogramming and redox signaling in cancer
Yang, H., Stern, A., & Chiu, D. T.-Y. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.08.001 · Cited by 96 · see citing works
Greco, C. M., Cervantes, M., Fustin, J., Ito, K., Ceglia, N., Samad, M., Shi, J., Koronowski, K. B., Forné, I., Ranjit, S., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5629 · Cited by 92 · see citing works
Non-enzymatic covalent modifications: a new link between metabolism and epigenetics
Zheng, Q., Maksimovic, I., Upad, A., & David, Y. (2020) · Protein & Cell · doi:10.1007/s13238-020-00722-w · Cited by 93 · see citing works
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro
Luchsinger, L. L., Strikoudis, A., Danzl, N. M., Bush, E. C., Finlayson, M. O., Satwani, P., Sykes, M., Yazawa, M., & Snoeck, H. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.05.002 · Cited by 88 · see citing works
The Molecular Link from Diet to Cancer Cell Metabolism
Bose, S., Allen, A. E., & Locasale, J. W. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.018 · Cited by 93 · see citing works
Self-citationHsieh, W., Sutter, B. M., Ruess, H., Barnes, S. D., Malladi, V. S., & Tu, B. P. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.12.015 · Cited by 88 · see citing works
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
Stone, O. A., El-Brolosy, M. A., Wilhelm, K., Liu, X., Romão, A. M., Grillo, E., Lai, J. K. H., Günther, S., Jeratsch, S., Kuenne, C. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06406-8 · Cited by 87 · see citing works
Self-citationTarazona, O. A., & Pourquié, O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.035 · Cited by 88 · see citing works
The Dual Roles of the Atypical Protein Kinase Cs in Cancer
Reina‐Campos, M., Díaz-Meco, M. T., & Moscat, J. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.07.010 · Cited by 82 · see citing works
Metabolic regulation of tissue stem cells
Shapira, S. N., & Christofk, H. R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.04.004 · Cited by 82 · see citing works
Pouikli, A., Parekh, S., Maleszewska, M., Nikopoulou, C., Baghdadi, M., Tripodi, I. J., Folz‐Donahue, K., Hinze, Y., Mesaros, A., Hoey, D. A., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00105-8 · Cited by 82 · see citing works
INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulation
Filippo, M. D., Pescini, D., Galuzzi, B. G., Bonanomi, M., Gaglio, D., Mangano, E., Consolandi, C., Alberghina, L., Vanoni, M., & Damiani, C. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009337 · Cited by 80 · see citing works
Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1
Beacon, T. H., Delcuve, G. P., & Davie, J. (2020) · Genome · doi:10.1139/gen-2020-0124 · Cited by 75 · see citing works
Mitochondria signaling to the epigenome: A novel role for an old organelle
Santos, J. H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.016 · Cited by 81 · see citing works
Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis
Saab, J. J. A., Dzierozynski, L. N., Jonker, P. B., AminiTabrizi, R., Shah, H., Menjivar, R. E., Scott, A. J., Nwosu, Z. C., Zhu, Z., Chen, R. N., et al. (2023) · eLife · doi:10.7554/elife.81289 · Cited by 80 · see citing works
Liu, T., Li, J., Yu, L., Sun, H., Li, J., Dong, G., Hu, Y., Li, Y., Shen, Y., Wu, J., et al. (2021) · Cell Discovery · doi:10.1038/s41421-020-00238-x · Cited by 76 · see citing works
Metabolic determinants of tumour initiation
Brunner, J. S., & Finley, L. W. S. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00773-5 · Cited by 76 · see citing works
Polymer folding through active processes recreates features of genome organization
Goychuk, A., Kannan, D., Chakraborty, A. K., & Mehran Kardar, A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221726120 · Cited by 71 · see citing works
The metabolic spectrum of memory T cells
O’Sullivan, D. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12274 · Cited by 75 · see citing works
Li, J., Zeng, G., Zhang, Z., Wang, Y., Shao, M., Li, C., Lu, Z., Zhao, Y. X., Zhang, F., & Ding, W. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116162 · Cited by 74 · see citing works
Cellular mechanisms linking cancers to obesity
Liu, X., Pedersen, L., & Halberg, N. (2021) · Cell Stress · doi:10.15698/cst2021.05.248 · Cited by 72 · see citing works
Lei, I., Tian, S., Gao, W., Liu, L., Guo, Y., Tang, P., Chen, E., & Wang, Z. (2021) · eLife · doi:10.7554/elife.60311 · Cited by 72 · see citing works
Metabolic plasticity and regulation of T cell exhaustion
Li, F., Liu, H., Zhang, D., Ma, Y., & Zhu, B. (2022) · Immunology · doi:10.1111/imm.13575 · Cited by 71 · see citing works
Gou, D., Liu, R., Shan, X., Deng, H., Chen, C., Jin, X., Liu, Y., Gao, Q., Li, Z., Huang, A., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci161713 · Cited by 71 · see citing works
Accelerating the Field of Epigenetic Histone Modification Through Mass Spectrometry–Based Approaches
Lu, C., Coradin, M., Porter, E. G. P., & Garcia, B. A. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r120.002257 · Cited by 70 · see citing works
Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
Simula, L., Campanella, M., & Campello, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104317 · Cited by 65 · see citing works
PI3K in stemness regulation: from development to cancer
Madsen, R. R. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190778 · Cited by 68 · see citing works
Microbiomes in the context of developing sustainable intensified aquaculture
Lorgen-Ritchie, M., Webster, T. M. U., McMurtrie, J., Bass, D., Tyler, C. R., Rowley, A. F., & Martín, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1200997 · Cited by 67 · see citing works
The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors
Cao, F., Zwinderman, M., & Dekker, F. (2018) · Molecules · doi:10.3390/molecules23030551 · Cited by 66 · see citing works
Nagu, P., Parashar, A., Behl, T., & Mehta, V. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01829-3 · Cited by 64 · see citing works
Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression
Crispo, F., Condelli, V., Lepore, S., Notarangelo, T., Sgambato, A., Esposito, F., Maddalena, F., & Landriscina, M. (2019) · Cells · doi:10.3390/cells8080798 · Cited by 61 · see citing works
The Bidirectional Relationship Between Cancer Epigenetics and Metabolism
Izzo, L., Affronti, H. C., & Wellen, K. E. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070820-035832 · Cited by 60 · see citing works
D’Aniello, C., Cermola, F., Palamidessi, A., Wanderlingh, L. G., Gagliardi, M., Migliaccio, A., Varrone, F., Casalino, L., Matarazzo, M. R., Cesare, D. D., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2070 · Cited by 60 · see citing works
Masoumi, M., Mehrabzadeh, M., Mahmoudzehi, S., Mousavi, M. J., Jamalzehi, S., Sahebkar, A., & Karami, J. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107064 · Cited by 60 · see citing works
Nojima, I., Eikawa, S., Tomonobu, N., Hada, Y., Kajitani, N., Teshigawara, S., Miyamoto, S., Tone, A., Uchida, H. A., Nakatsuka, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71946-3 · Cited by 58 · see citing works
Calcium regulation of stem cells
Snoeck, H. (2020) · EMBO Reports · doi:10.15252/embr.202050028 · Cited by 55 · see citing works
Mezawa, Y., & Orimo, A. (2021) · FEBS Journal · doi:10.1111/febs.15851 · Cited by 59 · see citing works
Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
Chen, C., Wang, Z., & Qin, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.935536 · Cited by 60 · see citing works
Metabolic intermediates – Cellular messengers talking to chromatin modifiers
Nieborak, A., & Schneider, R. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.007 · Cited by 56 · see citing works
Metabolic Control of m6A RNA Modification
Kim, J., & Lee, G. (2021) · Metabolites · doi:10.3390/metabo11020080 · Cited by 56 · see citing works
Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases
Yang, G., Xia, Y., & Ren, W. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1703-2 · Cited by 55 · see citing works
Metabolism navigates neural cell fate in development, aging and neurodegeneration
Traxler, L., Lagerwall, J., Eichhorner, S., Stefanoni, D., D’Alessandro, A., & Mertens, J. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048993 · Cited by 57 · see citing works
Desaulniers, D. M., Vasseur, P., Jacobs, A. C., Aguila, M. C., Ertych, N., & Jacobs, M. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010969 · Cited by 54 · see citing works
- Authors
- Reid, M. A., Dai, Z., & Locasale, J. W.
- Affiliations
- Duke University (US)
- Corresponding author
- Locasale, Jason W.
- Venue
- Nature Cell Biology
- Published
- 2017-10-23
- Volume
- 19
- Issue
- 11
- Pages
- 1298-1306
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC5886854
- OpenAlex
- W2767172151
- Cited by
- 515
- References
- 163
- Citations by year
- 2026: 49 · 2025: 49 · 2024: 51 · 2023: 48 · 2022: 80 · 2021: 68 · 2020: 83 · 2019: 55 · 2018: 30 · 2017: 1 · 2014: 1
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1s10od018164-01)
- National Cancer Institute (R00CA168997, R01CA193256, P30CA014236)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- cellular metabolism, chromatin dynamics, epigenetics, chromatin regulation, nutrient availability, metabolic pathways, genome regulation, developmental biology, tumor biology
- MeSH terms
- Animals, Chromatin, Humans, Neoplasms, Epigenesis, Genetic, Metabolic Networks and Pathways, Epigenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review