Maxfield, Frederick R.

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

Paresce, D. M., Ghosh, R. N., & Maxfield, F. R. (1996) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 663

Cholesterol, the central lipid of mammalian cells

Maxfield, F. R., & van Meer, G. (2010) · Current Opinion in Cell Biology

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 414

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

TCW, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., et al. (2022) · Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 411

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

Crespo, M., Vilar, E., Tsai, S.-Y., Chang, K., Amin, S., Srinivasan, T., Zhang, T., Pipalia, N. H., Chen, H. J., Witherspoon, M., et al. (2017) · Nature Medicine

Pluripotent Stem Cells ResearchCancer Cells and Metastasis

Cited by 399

Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages

Wang, Y., Subramanian, M., Yurdagul, A., Barbosa-Lorenzi, V. C., Cai, B., de Juan-Sanz, J., Ryan, T. A., Nomura, M., Maxfield, F. R., & Tabas, I. (2017) · Cell

Phagocytosis and Immune RegulationCell death mechanisms and regulation

Cited by 364

Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity.

Coats, B. R., Schoenfelt, K. Q., Barbosa-Lorenzi, V. C., Peris, E., Cui, C., Hoffman, A., Zhou, G., Fernandez, S., Zhai, L., Hall, B. A., et al. (2017) · Cell Reports

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 291

Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils

Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 271

Uptake, Degradation, and Release of Fibrillar and Soluble Forms of Alzheimer's Amyloid β-Peptide by Microglial Cells

Chung, H., Brazil, M. I., Soe, T. T., & Maxfield, F. R. (1999) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 212

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

Karuppagounder, S. S., Alim, I., Khim, S. J., Bourassa, M. W., Sleiman, S. F., John, R., Thinnes, C. C., Yeh, T.-L., Demetriades, M., Neitemeier, S., et al. (2016) · Science Translational Medicine

Intracerebral and Subarachnoid Hemorrhage ResearchNeonatal and fetal brain pathology

Cited by 141

The endocytic pathway in microglia during health, aging and Alzheimer’s disease

Solé-Domènech, S., Cruz, D. L., Capetillo-Zarate, E., & Maxfield, F. R. (2016) · Ageing Research Reviews

Neuroinflammation and Neurodegeneration MechanismsCellular transport and secretion

Cited by 133

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control

Pan, M., Maitin, V., Parathath, S., Andreo, U., Lin, S. X., Germain, C. S., Yao, Z., Maxfield, F. R., Williams, K. J., & Fisher, E. A. (2008) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyCholesterol and Lipid Metabolism

Cited by 128

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux

Jena, P. V., Roxbury, D., Galassi, T. V., Akkari, L., Horoszko, C. P., Iaea, D. B., Budhathoki-Uprety, J., Pipalia, N., Haka, A. S., Harvey, J. D., et al. (2017) · ACS Nano

Luminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics

Cited by 125

Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol

Murcia, M., Faráldo-Gómez, J. D., Maxfield, F. R., & Roux, B. (2006) · Journal of Lipid Research

Protein Structure and DynamicsLipid Membrane Structure and Behavior

Cited by 111

Deletion of ABCA1 and ABCG1 Impairs Macrophage Migration Because of Increased Rac1 Signaling

Pagler, T. A., Wang, M., Mondal, M., Murphy, A. J., Westerterp, M., Moore, K. J., Maxfield, F. R., & Tall, A. R. (2011) · Circulation Research

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 105

Progranulin in the hematopoietic compartment protects mice from atherosclerosis

Nguyen, A. D., Nguyen, T. A., Singh, R. K., Eberlé, D., Zhang, J., Abate, J. P., Robles, A., Koliwad, S., Huang, E. J., Maxfield, F. R., et al. (2018) · Atherosclerosis

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 23