Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control

Pan, Meihui; Maitin, Vatsala; Parathath, Sajesh; Andreo, Ursula; Lin, Sharron X.; Germain, Carly St.; Yao, Zemin; Maxfield, Frederick R.; Williams, Kevin Jon; Fisher, Edward A.

doi:10.1073/pnas.0707460104

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control

Hepatic secretion of apolipoprotein-B (apoB), the major protein of atherogenic lipoproteins, is regulated through posttranslational degradation. We reported a degradation pathway, post-ER pre secretory proteolysis (PERPP), that is increased by reactive oxygen species (ROS) generated within hepato…