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Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

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Bone Metabolism and DiseasesAlkaline Phosphatase Research Studies

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Tumor spectrum analysis in p53-mutant mice

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Cancer-related Molecular PathwaysCell death mechanisms and regulation

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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

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Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

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Protein Kinase Regulation and GTPase SignalingCancer-related Molecular Pathways

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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Microtubule and mitosis dynamicsCancer-related Molecular Pathways

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LKB1 modulates lung cancer differentiation and metastasis

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast

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Skeletal and CNS Defects in Presenilin-1-Deficient Mice

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Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

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A mouse model for Down syndrome exhibits learning and behaviour deficits

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Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

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Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

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Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

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CRISPR-mediated direct mutation of cancer genes in the mouse liver

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

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Mouse development and cell proliferation in the absence of D-cyclins

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Genome sequencing reveals insights into physiology and longevity of the naked mole rat

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PARP inhibition elicits STING-dependent antitumor immunity in brca1-deficient ovarian cancer

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Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

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The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer

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