Piña-Crespo, Juan C.

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Zhao, Y., Wu, X., Li, X., Jiang, L.-L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., et al. (2018) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 763

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Talantova, M., Sanz-Blasco, S., Zhang, X., Xia, P., Akhtar, M. W., Okamoto, S.-I., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., et al. (2013) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 600

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Jia, L., Piña-Crespo, J., & Li, Y. (2019) · Molecular Brain

Alzheimer's disease research and treatmentsWnt/β-catenin signaling in development and cancer

Cited by 288

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

Zhu, B., Liu, Y., Hwang, S., Archuleta, K., Huang, H., Campos, A., Murad, R., Piña-Crespo, J., Xu, H., & Huang, T. Y. (2022) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 127

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Trudler, D., Sanz-Blasco, S., Eisele, Y. S., Ghatak, S., Bodhinathan, K., Akhtar, M. W., Lynch, W. P., Piña-Crespo, J. C., Talantova, M., Kelly, J. W., et al. (2021) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 104

Exocytic trafficking is required for nicotine-induced up-regulation of α4β2 nicotinic acetylcholine receptors

Darsow, T., Booker, T. K., Piña-Crespo, J. C., & Heinemann, S. F. (2005) · Journal of Biological Chemistry

Nicotinic Acetylcholine Receptors StudyCellular transport and secretion

Cited by 76

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Huang, T. Y., Zhao, Y., Jiang, L.-L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J. C., Zhu, B., Masliah, E., Willnow, T. E., et al. (2017) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 50

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain

Huang, H., Shi, C. H., Yang, W., Piña-Crespo, J. C., Bhatnagar, J., Curatolo, J., Murad, R., Shah, P., Campos, A., Houser, A., et al. (2026) · Science Advances

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1