Nijhawan, Deepak

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell

Cell death mechanisms and regulationUbiquitin and proteasome pathways

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Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S., & Nijhawan, D. (2017) · Science

RNA Research and SplicingUbiquitin and proteasome pathways

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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell

Hippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancer

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P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., & McKnight, S. L. (2014) · Cell

Sirtuins and Resveratrol in MedicineNeuroprotection in Cerebral Ischemia

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Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820

Du, X., Volkov, O. A., Czerwinski, R. M., Tan, H., Huerta, C., Morton, E. R., Rizzi, J. P., Wehn, P. M., Xu, R., Nijhawan, D., et al. (2019) · Structure

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15

Ting, T. C., Goralski, M., Klein, K., Wang, B., Kim, J., Xie, Y., & Nijhawan, D. (2019) · Cell Reports

RNA Research and SplicingProtein Degradation and Inhibitors

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Selective targeting of mutant adenomatous polyposis coli ( APC ) in colorectal cancer

Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y.-A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., et al. (2016) · Science Translational Medicine

Colorectal Cancer Treatments and StudiesWnt/β-catenin signaling in development and cancer

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