P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

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Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels

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Turning enzymes ON with small molecules

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Biosynthesis of Diphosphopyridine Nucleotide

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Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

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P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

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P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

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Structure of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase

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Discovery of a Neuroprotective Chemical, ( S )- N -(3-(3,6-Dibromo-9 H -carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

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The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult‐generated neurons in the dentate gyrus

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Synthesis of Trifunctional Phosphatidylserine Probes for Identification of Lipid‐Binding Proteins

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Untitled work

Kolb (2001) · doi:10.1002/1521-3773(20010601)40:11

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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NAD+ metabolism and its roles in cellular processes during ageing

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SARM1 activation triggers axon degeneration locally via NAD ⁺ destruction

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NAD+ homeostasis in health and disease

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

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Interventions to slow aging in humans: are we ready?

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Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

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The landscape of aging

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NAD + Repletion Reverses Heart Failure With Preserved Ejection Fraction

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Implications of altered NAD metabolism in metabolic disorders

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Reducing acetylated tau is neuroprotective in brain injury

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Modulating NAD+ metabolism, from bench to bedside

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Development and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal Reaction

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The Influence of Nicotinamide on Health and Disease in the Central Nervous System

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Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

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Boosting NAD+ with a small molecule that activates NAMPT

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Age-related NAD+ decline

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Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3

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Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

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Novel targets for mitochondrial medicine

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Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes

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The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations

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Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases

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P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

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The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update

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Protecting the Aging Genome

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Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease

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NAD+ flux is maintained in aged mice despite lower tissue concentrations

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Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

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Enhancing NAD+ salvage pathway reverts the toxicity of primary astrocytes expressing amyotrophic lateral sclerosis-linked mutant superoxide dismutase 1 (SOD1)

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Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule

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Early Detection of Subclinical Visual Damage After Blast-Mediated TBI Enables Prevention of Chronic Visual Deficit by Treatment With P7C3-S243

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Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline–Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer’s Disease

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P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition

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Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration

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