Grimm, Dirk

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature

RNA Interference and Gene DeliveryMicroRNA in disease regulation

Cited by 1,677

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

Grimm, D., Lee, J. S., Wang, L., Desai, T., Akache, B., Storm, T. A., & Kay, M. A. (2008) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 696

Loss of epigenetic information as a cause of mammalian aging

Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 643

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 434

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6

Grimm, D., Kay, M. A., & Kleinschmidt, J. A. (2003) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 344

DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids

King, J. A., Dubielzig, R., Grimm, D., & Kleinschmidt, J. A. (2001) · The EMBO Journal

Virus-based gene therapy researchDNA Repair Mechanisms

Cited by 338

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Weinmann, J., Weis, S., Sippel, J., Tulalamba, W., Remes, A., El Andari, J., Herrmann, A.-K., Pham, Q. H., Borowski, C., Hille, S., et al. (2020) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 259

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy

Amoasii, L., Long, C., Li, H., Mireault, A. A., Shelton, J. M., Sanchez-Ortiz, E., McAnally, J. R., Bhattacharyya, S., Schmidt, F., Grimm, D., et al. (2017) · Science Translational Medicine

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 247

Subcellular compartmentalization of adeno-associated virus type 2 assembly

Wistuba, A., Kern, A., Weger, S., Grimm, D., & Kleinschmidt, J. A. (1997) · Journal of Virology

Virus-based gene therapy researchParvovirus B19 Infection Studies

Cited by 219

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

Grimm, D., Wang, L., Lee, J. S., Schürmann, N., Gu, S., Börner, K., Storm, T. A., & Kay, M. A. (2010) · Journal of Clinical Investigation

RNA Interference and Gene DeliveryVirus-based gene therapy research

Cited by 196

Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2

Grimm, D., Kern, A., Pawlita, M., Ferrari, F. K., Samulski, R. J., & Kleinschmidt, J. A. (1999) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 195

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Hakim, C. H., Kumar, S. R. P., Pérez-López, D. O., Wasala, N. B., Zhang, D., Yue, Y., Teixeira, J., Pan, X., Zhang, K., Million, E. D., et al. (2021) · Nature Communications

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 175

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Rezvani, M., Español-Suñer, R., Malato, Y., Dumont, L., Grimm, A. A., Kienle, E., Bindman, J. G., Wiedtke, E., Hsu, B. Y., Naqvi, S. J., et al. (2016) · Cell Stem Cell

Liver physiology and pathologyVirus-based gene therapy research

Cited by 150

Next-generation AAV vectors—Do not judge a virus (only) by its cover

Domenger, C., & Grimm, D. (2019) · Human Molecular Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 147

Liver Transduction with Recombinant Adeno-Associated Virus Is Primarily Restricted by Capsid Serotype Not Vector Genotype

Grimm, D., Pandey, K., Nakai, H., Storm, T. A., & Kay, M. A. (2006) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 118

AAV vector-mediated in vivo reprogramming into pluripotency

Senís, E., Mosteiro, L., Wilkening, S., Wiedtke, E., Nowrouzi, A., Afzal, S., Fronza, R., Landerer, H., Abad, M., Niopek, D., et al. (2018) · Nature Communications

Pluripotent Stem Cells ResearchVirus-based gene therapy research

Cited by 64

T160-phosphorylated CDK2 defines threshold for HGF-dependent proliferation in primary hepatocytes

Mueller, S., Huard, J., Waldow, K., Huang, X., D'Alessandro, L. A., Bohl, S., Börner, K., Grimm, D., Klamt, S., Klingmüller, U., et al. (2015) · Molecular Systems Biology

Liver physiology and pathologyCancer-related Molecular Pathways

Cited by 23

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J. M., Ibarra, I. L., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2025) · Nature Genetics

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 17

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J., Ibarra, I., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2024) · Nature Genetics

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 17