Wells, James A.

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A., & Shokat, K. M. (2013) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 2,557

Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

Arkin, M. R., & Wells, J. A. (2004) · Nature Reviews Drug Discovery

Chemical Synthesis and AnalysisProtein Degradation and Inhibitors

Cited by 1,705

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

Arkin, M. R., Tang, Y., & Wells, J. A. (2014) · Chemistry & Biology

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 1,065

Caspases and their substrates

Julien, O., & Wells, J. A. (2017) · Cell Death & Differentiation

Cell death mechanisms and regulationInflammasome and immune disorders

Cited by 816

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

Cotton, A. D., Nguyen, D. P., Gramespacher, J. A., Seiple, I. B., & Wells, J. A. (2021) · Journal of the American Chemical Society

Protein Degradation and InhibitorsMonoclonal and Polyclonal Antibodies Research

Cited by 551

Site-directed ligand discovery

Erlanson, D. A., Braisted, A. C., Raphael, D. R., Randal, M., Stroud, R. M., Gordon, E. M., & Wells, J. A. (2000) · Proceedings of the National Academy of Sciences

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 466

Tethering: Fragment-Based Drug Discovery

Erlanson, D. A., Wells, J. A., & Braisted, A. C. (2004) · Annual Review of Biophysics and Biomolecular Structure

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 385

Repairing research integrity

Titus, S. L., Wells, J. A., & Rhoades, L. J. (2008) · Nature

Academic integrity and plagiarismAcademic Publishing and Open Access

Cited by 300

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

Wang, W., Nguyen, L. T. T., Burlak, C., Chegini, F., Guo, F., Chataway, T., Ju, S., Fisher, O. S., Miller, D. W., Datta, D., et al. (2016) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 270

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins

Pance, K., Gramespacher, J. A., Byrnes, J. R., Salangsang, F., Serrano, J.-A. C., Cotton, A. D., Steri, V., & Wells, J. A. (2023) · Nature Biotechnology

Protein Degradation and InhibitorsMonoclonal and Polyclonal Antibodies Research

Cited by 265

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

Glasgow, A., Glasgow, J., Limonta, D., Solomon, P., Lui, I., Zhang, Y., Nix, M. A., Rettko, N. J., Zha, S., Yamin, R., et al. (2020) · Proceedings of the National Academy of Sciences

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 251

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability

Li, Z., Ferguson, L., Deol, K. K., Roberts, M. A., Magtanong, L., Hendricks, J. M., Mousa, G. A., Kilinc, S., Schaefer, K., Wells, J. A., et al. (2022) · Nature Chemical Biology

Selenium in Biological SystemsFerroptosis and cancer prognosis

Cited by 134

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay

Peluso, M. J., Takahashi, S., Hakim, J., Kelly, J. D., Torres, L., Iyer, N. S., Turcios, K., Janson, O., Munter, S. E., Thanh, C., et al. (2021) · Science Advances

SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testing

Cited by 130

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Martinko, A. J., Truillet, C., Julien, O., Diaz, J. E., Horlbeck, M. A., Whiteley, G., Blonder, J., Weissman, J. S., Bandyopadhyay, S., Evans, M. J., et al. (2018) · eLife

Protein Kinase Regulation and GTPase SignalingProtein Degradation and Inhibitors

Cited by 91

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes

Leung, K. K., Wilson, G. M., Kirkemo, L. L., Riley, N. M., Coon, J. J., & Wells, J. A. (2020) · Proceedings of the National Academy of Sciences

Glycosylation and Glycoproteins ResearchAdvanced Proteomics Techniques and Applications

Cited by 83

CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning

Teter, O. M., McQuade, A., Hagan, V., Liang, W., Dräger, N. M., Sattler, S. M., Holmes, B. B., Castillo, V. C., Papakis, V., Leng, K., et al. (2025) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAutism Spectrum Disorder Research

Cited by 38

Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells

Bartholow, T. G., Burroughs, P. W. W., Elledge, S. K., Byrnes, J. R., Kirkemo, L. L., Garda, V., Leung, K. K., & Wells, J. A. (2024) · ACS Central Science

Biotin and Related StudiesClick Chemistry and Applications

Cited by 32

Engineering an interfacial zinc site to increase hormone-receptor affinity

Matthews, D. J., & Wells, J. A. (1994) · Chemistry & Biology

Growth Hormone and Insulin-like Growth FactorsReceptor Mechanisms and Signaling

Cited by 12