Walden, Helen

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., et al. (2012) · Open Biology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Zhuang, M., Calabrese, M. F., Liu, J., Waddell, M. B., Nourse, A., Hammel, M., Miller, D. J., Walden, H., Duda, D. M., Seyedin, S. N., et al. (2009) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

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Autoregulation of Parkin activity through its ubiquitin‐like domain

Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S., & Walden, H. (2011) · The EMBO Journal

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

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Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

Rennie, M. L., Arkinson, C., Chaugule, V. K., & Walden, H. (2022) · Science Advances

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

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Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279

Rennie, M. L., Gundogdu, M., Arkinson, C., Liness, S., Frame, S., & Walden, H. (2024) · Journal of Medicinal Chemistry

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

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A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1

Koszela, J., Rintala-Dempsey, A., Salzano, G., Pimenta, V., Kamarainen, O., Gabrielsen, M., Parui, A. L., Shaw, G. S., & Walden, H. (2025) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

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