Flach, Johanna

Autophagy maintains the metabolism and function of young and old stem cells

Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E., & Passegué, E. (2017) · Nature

Hematopoietic Stem Cell TransplantationAutophagy in Disease and Therapy

Cited by 896

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Flach, J., Bakker, S. T., Mohrin, M., Conroy, P. C., Pietras, E. M., Reynaud, D., Alvarez, S., Diolaiti, M. E., Ugarte, F., Forsberg, E. C., et al. (2014) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 650

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Warr, M. R., Binnewies, M., Flach, J., Reynaud, D., Garg, T., Malhotra, R., Debnath, J., & Passegué, E. (2013) · Nature

Autophagy in Disease and TherapyHematopoietic Stem Cell Transplantation

Cited by 625

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

Schepers, K., Pietras, E. M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A. J., Hsiao, E. C., & Passegué, E. (2013) · Cell stem cell

Myeloproliferative Neoplasms: Diagnosis and TreatmentHematopoietic Stem Cell Transplantation

Cited by 614

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

Pietras, E. M., Lakshminarasimhan, R., Techner, J.-M., Fong, S., Flach, J., Binnewies, M., & Passegué, E. (2014) · Journal of Experimental Medicine

Hematopoietic Stem Cell Transplantationinterferon and immune responses

Cited by 323

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

Ho, T. T., Dellorusso, P. V., Verovskaya, E. V., Bakker, S. T., Flach, J., Smith, L. K., Ventura, P. B., Lansinger, O. M., Hérault, A., Zhang, S. Y., et al. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

Cited by 101