Barbacid, Mariano

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

Drosten, M., Sum, E. Y. M., Lechuga, C. G., Simón-Carrasco, L., Jacob, H. K. C., García-Medina, R., Huang, S., Beijersbergen, R. L., Bernards, R., & Barbacid, M. (2014) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 103

K-Ras V14I recapitulates Noonan syndrome in mice

Hernández-Porras, I., Fabbiano, S., Schuhmacher, A. J., Aicher, A., Cañamero, M., Cámara, J. A., Cussó, L., Desco, M., Heeschen, C., Mulero, F., et al. (2014) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 96

Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes

Mart�n, J., Usac, E. F., Franco, C., Barbacid, M., Gomis, R., Marzo, N., Mora, C., & Fabregat, M. E. (2004) · Diabetologia

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 65

Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas

Salmón, M., Álvarez-Díaz, R., Fustero-Torre, C., Brehey, O., Lechuga, C. G., Sanclemente, M., Fernández-García, F., López-García, A., Martín-Guijarro, M. C., Rodríguez-Perales, S., et al. (2023) · Journal of Clinical Investigation

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 52

Ras signaling is essential for skin development

Drosten, M., Lechuga, C. G., & Barbacid, M. (2014) · Oncogene

Protein Kinase Regulation and GTPase SignalingHair Growth and Disorders

Cited by 46

KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors

Paniagua, G., Jacob, H. K. C., Brehey, O., García‐Alonso, S., Lechuga, C. G., Pons, T., Musteanu, M., Guerra, C., Drosten, M., & Barbacid, M. (2022) · Molecular Oncology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 34

KRAS inhibitors: going noncovalent

Drosten, M., & Barbacid, M. (2022) · Molecular Oncology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 13

Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein

Janssen, K., Claes, F., Van de Velde, D., Wehbi, V. L., Houben, B., Lampi, Y., Nys, M., Khodaparast, L., Khodaparast, L., Louros, N., et al. (2023) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingChemical Synthesis and Analysis

Cited by 10