Ras signaling is essential for skin development

p21 in cancer: Intricate networks and multiple activities

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Statistical analysis of real-time PCR data

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RAS oncogenes: the first 30 years

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RAS oncogenes: weaving a tumorigenic web

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The cornified envelope: a model of cell death in the skin

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Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

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Epidermal homeostasis: a balancing act of stem cells in the skin

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The Regulation of INK4/ARF in Cancer and Aging

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Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

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Asymmetric cell divisions promote stratification and differentiation of mammalian skin

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Molecular Mechanisms Regulating Hair Follicle Development

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Scratching the surface of skin development

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Epidermal differentiation: the bare essentials.

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

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A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis

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K-ras is an essential gene in the mouse with partial functional overlap with N-rasPreprint

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Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

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Methods to Detect Biomarkers of Cellular Senescence

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Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

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Programming gene expression in developing epidermis

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p63 regulates proliferation and differentiation of developmentally mature keratinocytesPreprint

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Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

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The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.Preprint

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EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

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The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

Rojas, A. M., Fuentes, G., Rausell, A., & Valencia, A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201103008 · Cited by 378 · see citing works

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

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Mechanisms Regulating Epithelial Stratification

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Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development

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p63 deficiency activates a program of cellular senescence and leads to accelerated agingPreprint

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The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

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Inhibitory Function of p21 Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control

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More than one way to skin . . .

Fuchs, E., & Horsley, V. (2008) · Genes & Development · doi:10.1101/gad.1645908 · Cited by 224 · see citing works

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Kölch, W., & Pitt, A. R. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2900 · Cited by 200 · see citing works

A keratin K5Cre transgenic line appropriate for tissue‐specific or generalized cre‐mediated recombination

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Hairy tale of signaling in hair follicle development and cycling

Lee, J., & Tumbar, T. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.003 · Cited by 188 · see citing works

A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning

Petiot, A., Conti, F. J. A., Grose, R. P., Revest, J., Hodivala‐Dilke, K., & Dickson, C. (2003) · Development · doi:10.1242/dev.00788 · Cited by 176 · see citing works

Making an Epidermis

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p 21WAF1 C ontrol of E pithelial C ell C ycle and C ell F ate

Weinberg, W. C., & Denning, M. F. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300603 · Cited by 150 · see citing works

p63 in epithelial development

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Ras/Erk MAPK Signaling in Epidermal Homeostasis and Neoplasia

Khavari, T. A., & Rinn, J. L. (2007) · Cell Cycle · doi:10.4161/cc.6.23.4998 · Cited by 145 · see citing works

Mek1/2 MAPK Kinases Are Essential for Mammalian Development, Homeostasis, and Raf-Induced Hyperplasia

Scholl, F. A., Dumesic, P. A., Barragan, D. I., Harada, K., Bissonauth, V., Charron, J., & Khavari, P. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.009 · Cited by 142 · see citing works

Cell Cycle and Hormonal Control of Nuclear-Cytoplasmic Localization of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, in Mammary Tumor Cells

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Conditional Expression of K- ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis

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Replacement of K‐Ras with H‐Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice

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Erk1/2 MAP kinases are required for epidermal G2/M progression

Dumesic, P. A., Scholl, F. A., Barragan, D. I., & Khavari, P. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200804038 · Cited by 97 · see citing works

Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

Dajee, M., Tarutani, M., Deng, H., Cai, T., & Khavari, P. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205287 · Cited by 94 · see citing works

Skin epidermis lacking the c-myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21 Cip1 genePreprint

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Inducible activation of Ras and Raf in adult epidermis.

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Mek1 Alters Epidermal Growth and Differentiation

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Ras and Raf pathways in epidermis development and carcinogenesis

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The Dominant Negative Ras Mutant, N17Ras, Can Inhibit Signaling Independently of Blocking Ras Activation

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Erratum: Ras and Raf pathways in epidermis development and carcinogenesis

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Hair growth in mouse mutants affecting coat texture

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RAS-targeted therapies: is the undruggable drugged?

Moore, A. R., Rosenberg, S. C., McCormick, F., & Malek, S. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0068-6 · Cited by 1,103 · see citing works

Expanding the Reach of Precision Oncology by Drugging All <i>KRAS</i> Mutants

Hofmann, M. H., Gerlach, D., Misale, S., Petronczki, M., & Kraut, N. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1331 · Cited by 336 · see citing works

Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth

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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

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Injury prevents Ras mutant cell expansion in mosaic skin

Gallini, S., Annusver, K., Rahman, N.-T., Gonzalez, D. G., Yun, S., Matte-Martone, C. C., Xin, T., Lathrop, E., Suozzi, K. C., Kasper, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06198-y · Cited by 41 · see citing works

Small molecular inhibitors for KRAS-mutant cancers

Wu, X., Song, W., Cheng, C., Liu, Z., Li, X., Cui, Y., Gao, Y., & Ding, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1223433 · Cited by 41 · see citing works

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

Park, J., Overbey, E. G., Narayanan, S. A., Kim, J., Tierney, B. T., Damle, N., Najjar, D., Ryon, K. A., Proszynski, J., Kleinman, A. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48625-2 · Cited by 40 · see citing works

Exceptionally high-affinity Ras binders that remodel its effector domain

McGee, J. H., Shim, S. Y., Lee, S., Swanson, P. K., Jiang, S. Y., Durney, M. A., & Verdine, G. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.816348 · Cited by 39 · see citing works

SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology

Baltanás, F. C., García‐Navas, R., & Santos, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126613 · Cited by 32 · see citing works

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis

Liceras-Boillos, P., Jimeno, D., García‐Navas, R., Lorenzo‐Martín, L. F., Menacho-Márquez, M., Segrelles, C., Gómez, C., Calzada, N., Fuentes‐Mateos, R., Paramio, J. M., et al. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00049-18 · Cited by 30 · see citing works

Promises and challenges of senolytics in skin regeneration, pathology and ageing

Pils, V., Ring, N., Valdivieso, K., Lämmermann, I., Грубер, Ф., Schosserer, M., Grillari, J., & Ogrodnik, M. B. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111588 · Cited by 32 · see citing works

Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification

Tedeschi, A., Schischlik, F., Rocchetti, F., Popow, J., Ebner, F., Gerlach, D., Geyer, A., Santoro, V., Boghossian, A. S., Rees, M. G., et al. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-24-0386 · Cited by 26 · see citing works

MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity

Solvin, Å. Ø., Chawla, K., Olsen, L. C., Hegre, S. A., Danielsen, K., Jenssen, M., Furberg, A., Saunes, M., Hveem, K., Sætrom, P., et al. (2021) · Experimental Dermatology · doi:10.1111/exd.14497 · Cited by 26 · see citing works

Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care

Thompson, E. L., Pitcher, L. E., Niedernhofer, L. J., & Robbins, P. D. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009668 · Cited by 26 · see citing works

Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak

Bao, Q., Ma, X., Jia, C., Wu, X., Wu, Y., Meng, G., Bao, P., Chu, M., Guo, X., Liang, C., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.798076 · Cited by 22 · see citing works

CBP/p300 antagonises EGFR‐Ras‐Erk signalling and suppresses increased Ras‐Erk signalling‐induced tumour formation in mice

Ichise, T., Yoshida, N., & Ichise, H. (2019) · The Journal of Pathology · doi:10.1002/path.5279 · Cited by 18 · see citing works

Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS

Liu, X., Zhang, Y., Wang, S., Liu, G., & Ruan, L. (2018) · Royal Society Open Science · doi:10.1098/rsos.172376 · Cited by 17 · see citing works

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Ma, J., Fu, S., Tan, J., Han, Y., Chen, Y., Deng, X., Shen, H., Zeng, S., Peng, Y., & Cai, C. (2025) · Advanced Science · doi:10.1002/advs.202502714 · Cited by 17 · see citing works

Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis

Baltanás, F. C., Mucientes-Valdivieso, C., Lorenzo‐Martín, L. F., Fernández-Parejo, N., García‐Navas, R., Segrelles, C., Calzada, N., Fuentes‐Mateos, R., Paramio, J. M., Bustelo, X. R., et al. (2021) · Cancers · doi:10.3390/cancers13092152 · Cited by 13 · see citing works

Genetic analysis of Ras genes in epidermal development and tumorigenesis

Drosten, M., Lechuga, C. G., & Barbacid, M. (2013) · Small GTPases · doi:10.4161/sgtp.26905 · Cited by 12 · see citing works

Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma

Droll, S. H., & Bao, X. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000433 · Cited by 12 · see citing works

Investigation of Candidate Genes and Pathways in Basal/TNBC Patients by Integrated Analysis

Liu, Q., Song, X., Liu, Z., & Yu, Z. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211019506 · Cited by 11 · see citing works

Single cell spatial biology over developmental time can decipher pediatric brain pathologies

Nussinov, R., Yavuz, B. R., & Jang, H. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106597 · Cited by 11 · see citing works

Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs

Tiwari, P., Sahay, S., Pandey, M., Qadri, S. S. Y. H., & Gupta, K. P. (2015) · Biochimie · doi:10.1016/j.biochi.2015.11.027 · Cited by 11 · see citing works

Potential use of angiotensin receptor blockers in skin pathologies.

Hedayatyanfard, K., Khalili, A., Karim, H., Nooraei, S., Khosravi, E., Haddadi, N., Dehpour, A. R., & Bayat, G. (2023) · PubMed Central · doi:10.22038/ijbms.2023.66563.14606 · Cited by 10 · see citing works

Comparison of hair manifestations in cardio‐facio‐cutaneous and Costello syndromes highlights the influence of the RAS pathway on hair growth

Urban, J., Qi, L., Zhao, H., Rybak, I., Rauen, K. A., & Kiuru, M. H. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16082 · Cited by 10 · see citing works

Y-27632 preserves epidermal integrity in a human skin organ-culture (hSOC) system by regulating AKT and ERK signaling pathways

Zhang, X., Qin, J., Xie, Z., Liu, C. X., Su, Y., Chen, Z., Zhou, Q., Ma, C., Liu, G., Paus, R., et al. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.10.006 · Cited by 9 · see citing works

Integrated Analysis of lncRNA and mRNA Reveals Novel Insights into Wool Bending in Zhongwei Goat

Li, X., Liu, Z., Ye, S., Liu, Y., Chen, Q., Guan, W., Pu, Y., Jiang, L., He, X., Ma, Y., et al. (2021) · Animals · doi:10.3390/ani11113326 · Cited by 9 · see citing works

Elucidation of the Potential Hair Growth-Promoting Effect of Botryococcus terribilis, Its Novel Compound Methylated-Meijicoccene, and C32 Botryococcene on Cultured Hair Follicle Dermal Papilla Cells Using DNA Microarray Gene Expression Analysis

Mizushima, A. K. O., Bejaoui, M., Hirano, A., Arimura, T., Linh, T. N., Uchiage, E., Nukaga, S., Tominaga, K., Nozaki, H., & Isoda, H. (2022) · Biomedicines · doi:10.3390/biomedicines10051186 · Cited by 9 · see citing works

Cutaneous manifestations in Costello syndrome: HRAS p.Gly12Ser affects RIN1-mediated integrin trafficking in immortalized epidermal keratinocytes

Nauth, T., Bazgir, F., Voß, H., Brandenstein, L., Mosaddeghzadeh, N., Rickassel, V., Deden, S., Gorzelanny, C., Schlüter, H., Ahmadian, M. R., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac188 · Cited by 8 · see citing works

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis

Monedeiro, F., Ehall, B., Tiffner, K., Eberl, A., Švehlíková, E., Prietl, B., Pfeifer, V., Senekowitsch, J., Remm, A., Rebane, A., et al. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00153 · Cited by 8 · see citing works

Cutis verticis gyrata and Noonan syndrome: report of two cases with pathogenetic variant in SOS1 gene

Mercadante, F., Piro, E., Busè, M., Salzano, E., Ferrara, A., Serra, G., Passarello, C., Corsello, G., & Piccione, M. (2022) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-022-01340-4 · Cited by 6 · see citing works

A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders

Antonatos, C., Pontikas, A., Akritidis, A., Mitsoudi, D., Georgiou, S., Stratigos, A. J., Zacharopoulou, A., Gregoriou, S., Grafanaki, K., & Vasilopoulos, Y. (2025) · Human Genomics · doi:10.1186/s40246-025-00801-1 · Cited by 5 · see citing works

Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes

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The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene

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