Keen, Nicholas
Novartis Institutes for BioMedical Research
10 papers on CoChatORCID 0000-0003-0741-3716
Most cited papers
- Verified
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
Gao, H., Korn, J. M., Ferretti, S., Monahan, J. E., Wang, Y., Singh, M., Zhang, C., Schnell, C., Yang, G., Zhang, Y., et al. (2015) · Nature Medicine
Cancer Cells and MetastasisCancer Genomics and Diagnostics
Cited by 1,393
- Verified
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Chen, Y.-N. P., LaMarche, M. J., Chan, H. M., Fekkes, P., Garcia-Fortanet, J., Acker, M. G., Antonakos, B., Chen, C. H.-T., Chen, Z., Cooke, V. G., et al. (2016) · Nature
Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling
Cited by 925
- Verified
Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening
McDonald, E. R., de Weck, A., Schlabach, M. R., Billy, E., Mavrakis, K. J., Hoffman, G. R., Belur, D., Castelletti, D., Frias, E., Gampa, K., et al. (2017) · Cell
Chromatin Remodeling and CancerCancer Genomics and Diagnostics
Cited by 658
- Verified
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Mavrakis, K. J., McDonald, E. R., Schlabach, M. R., Billy, E., Hoffman, G. R., deWeck, A., Ruddy, D. A., Venkatesan, K., Yu, J., McAllister, G., et al. (2016) · Science
Cancer-related gene regulationRNA modifications and cancer
Cited by 607
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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
Bhang, H.-E. C., Ruddy, D. A., Krishnamurthy Radhakrishna, V., Caushi, J. X., Zhao, R., Hims, M. M., Singh, A. P., Kao, I., Rakiec, D., Shaw, P., et al. (2015) · Nature Medicine
Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics
Cited by 507
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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Hoffman, G. R., Rahal, R., Buxton, F., Xiang, K., McAllister, G., Frias, E., Bagdasarian, L., Huber, J., Lindeman, A., Chen, D., et al. (2014) · Proceedings of the National Academy of Sciences
Chromatin Remodeling and CancerEpigenetics and DNA Methylation
Cited by 421
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Structural Basis of Substrate Methylation and Inhibition of SMYD2
Ferguson, A. D., Larsen, N. A., Howard, T., Pollard, H., Green, I., Grande, C., Cheung, T., Garcia-Arenas, R., Cowen, S., Wu, J., et al. (2011) · Structure
Cancer-related gene regulationEpigenetics and DNA Methylation
Cited by 203
- Verified
Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
Gibaja, V, Shen, F., Harari, J., Korn, J., Ruddy, D., Saenz-Vash, V, Zhai, H., Rejtar, T., Paris, C. G., Yu, Z., et al. (2016) · Oncogene
Epigenetics and DNA MethylationChromatin Remodeling and Cancer
Cited by 149
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Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6– Reactivating Rb in cancer.
Kim, S., Loo, A., Chopra, R., Caponigro, G., Huang, A., Vora, S., Parasuraman, S., Howard, S., Keen, N., Sellers, W., et al. (2013) · Molecular Cancer Therapeutics
Advanced Breast Cancer TherapiesCancer-related Molecular Pathways
Cited by 106
- Verified
Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex
Keen, N. J., Churcher, M. J., & Karn, J. (1997) · The EMBO Journal
HIV Research and TreatmentGenomics and Chromatin Dynamics
Cited by 59
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