Roth, Adrian

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

Trietsch, S. J., Naumovska, E., Kurek, D., Setyawati, M. C., Vormann, M. K., Wilschut, K. J., Lanz, H. L., Nicolas, A., Ng, C. P., Joore, J., et al. (2017) · Nature Communications

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 290

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

Kostadinova, R., Boess, F., Applegate, D., Suter, L., Weiser, T., Singer, T., Naughton, B., & Roth, A. (2013) · Toxicology and Applied Pharmacology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 262

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

McAleer, C. W., Long, C. J., Elbrecht, D., Sasserath, T., Bridges, L. R., Rumsey, J. W., Martin, C., Schnepper, M., Wang, Y., Schuler, F., et al. (2019) · Science Translational Medicine

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 199

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

Baudy, A. R., Otieno, M. A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T. R., & Proctor, W. R. (2020) · Lab on a Chip

3D Printing in Biomedical ResearchDrug-Induced Hepatotoxicity and Protection

Cited by 150

Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity

DesRochers, T. M., Suter, L., Roth, A., & Kaplan, D. L. (2013) · PLoS ONE

Acute Kidney Injury ResearchChemotherapy-induced organ toxicity mitigation

Cited by 128

Human microphysiological systems for drug development

Roth, A., & 2019, M.-W. B. (2021) · Science

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 94

Minimizing DILI risk in drug discovery — A screening tool for drug candidates

Schadt, S., Simon, S., Kustermann, S., Boess, F., McGinnis, C., Brink, A., Lieven, R., Fowler, S., Youdim, K., Ullah, M., et al. (2015) · Toxicology in Vitro

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 89

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

Kerns, S. J., Belgur, C., Petropolis, D., Kanellias, M., Barrile, R., Sam, J., Weinzierl, T., Fauti, T., Freimoser-Grundschober, A., Eckmann, J., et al. (2021) · eLife

3D Printing in Biomedical ResearchImmunotoxicology and immune responses

Cited by 82

Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

Zhang, J. D., Berntenis, N., Roth, A., & Ebeling, M. (2014) · The Pharmacogenomics Journal

Drug-Induced Hepatotoxicity and ProtectionComputational Drug Discovery Methods

Cited by 79

Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia

Sewing, S., Roth, A. B., Winter, M., Dieckmann, A., Bertinetti-Lapatki, C., Tessier, Y., McGinnis, C., Huber, S., Koller, E., Ploix, C., et al. (2017) · PLOS ONE

Platelet Disorders and TreatmentsDNA and Nucleic Acid Chemistry

Cited by 52