Cited by 1993D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsDrug Transport and Resistance Mechanisms

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

McAleer, Christopher W., Long, Christopher J., Elbrecht, Daniel, Sasserath, Trevor, Bridges, L. Richard, Rumsey, John W., Martin, Candace, Schnepper, Mark +6 more·2019·Science Translational Medicine

Abstract

An in vitro multi-organ system evaluates the efficacy and potential off-target toxicities of anticancer parent drugs and metabolites.

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.aav1386

Cites

53 of 53 references verified0 citation errors · 0 not checkable

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  • Hickman's group found that antileukemia drugs can be tested by coculturing primary human hepatocytes and human bone marrow cell cultures of two types of cancer in a chip model.

    “Subsequently, Hickman’s group found that antileukemia drugs can be tested by coculturing primary human hepatocytes and human bone marrow cell cultures of two types of cancer in a chip model (Fig. 8d)230.”
  • Diclofenac and imatinib have cytostatic effects on bone marrow.

    “Diclofenac and imatinib have cytostatic effects on bone marrow.”

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Authors
McAleer, C. W., Long, C. J., Elbrecht, D., Sasserath, T., Bridges, L. R., Rumsey, J. W., Martin, C., Schnepper, M., Wang, Y., Schuler, F., Roth, A. B., Funk, C., Shuler, M. L., & Hickman, J. J.
Affiliations
  • Hesperos (United States) (US)
  • University of Central Florida (US)
  • F. Hoffmann-La Roche AG (CH)
Corresponding author
  • McAleer, Christopher W.
  • Long, Christopher J.
  • Hickman, James J.
Venue
Science Translational Medicine
Published
2019-06-19
Volume
11
Issue
497
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2949138884
Cited by
199
References
53
Citations by year
2026: 32 · 2025: 32 · 2024: 30 · 2023: 24 · 2022: 23 · 2021: 24 · 2020: 26 · 2019: 8
FWCI
7.13
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R44TR001326)
  • Hoffman-La Roche (NA)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
multi-organ-on-a-chip, off-target toxicity, anticancer drug efficacy, drug metabolism, drug metabolites, primary human hepatocytes, diclofenac, imatinib, tamoxifen, verapamil, P-glycoprotein, cardiotoxicity, iPSC-derived cardiomyocytes, drug repurposing, alternatives to animal testing
MeSH terms
Imatinib Mesylate, Antineoplastic Agents, Cells, Cultured, Diclofenac, Drug Evaluation, Preclinical, Humans, Tamoxifen, Verapamil, Cell Proliferation, Lab-On-A-Chip Devices

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