Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics
Abstract
An in vitro multi-organ system evaluates the efficacy and potential off-target toxicities of anticancer parent drugs and metabolites.
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Hickman's group found that antileukemia drugs can be tested by coculturing primary human hepatocytes and human bone marrow cell cultures of two types of cancer in a chip model.
“Subsequently, Hickman’s group found that antileukemia drugs can be tested by coculturing primary human hepatocytes and human bone marrow cell cultures of two types of cancer in a chip model (Fig. 8d)230.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [230]
Diclofenac and imatinib have cytostatic effects on bone marrow.
“Diclofenac and imatinib have cytostatic effects on bone marrow.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [230]
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- Authors
- McAleer, C. W., Long, C. J., Elbrecht, D., Sasserath, T., Bridges, L. R., Rumsey, J. W., Martin, C., Schnepper, M., Wang, Y., Schuler, F., Roth, A. B., Funk, C., Shuler, M. L., & Hickman, J. J.
- Affiliations
- Hesperos (United States) (US)
- University of Central Florida (US)
- F. Hoffmann-La Roche AG (CH)
- Corresponding author
- McAleer, Christopher W.
- Long, Christopher J.
- Hickman, James J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-06-19
- Volume
- 11
- Issue
- 497
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2949138884
- Cited by
- 199
- References
- 53
- Citations by year
- 2026: 32 · 2025: 32 · 2024: 30 · 2023: 24 · 2022: 23 · 2021: 24 · 2020: 26 · 2019: 8
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R44TR001326)
- Hoffman-La Roche (NA)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- multi-organ-on-a-chip, off-target toxicity, anticancer drug efficacy, drug metabolism, drug metabolites, primary human hepatocytes, diclofenac, imatinib, tamoxifen, verapamil, P-glycoprotein, cardiotoxicity, iPSC-derived cardiomyocytes, drug repurposing, alternatives to animal testing
- MeSH terms
- Imatinib Mesylate, Antineoplastic Agents, Cells, Cultured, Diclofenac, Drug Evaluation, Preclinical, Humans, Tamoxifen, Verapamil, Cell Proliferation, Lab-On-A-Chip Devices
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