Sparrow, Janet R.

RPE lipofuscin and its role in retinal pathobiology

Sparrow, J. R., & Boulton, M. (2005) · Experimental Eye Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 644

Isolation and one-step preparation of A2E and iso -A2E, fluorophores from human retinal pigment epithelium

Parish, C. A., Hashimoto, M., Nakanishi, K., Dillon, J., & Sparrow, J. (1998) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 474

The bisretinoids of retinal pigment epithelium

Sparrow, J. R., Gregory-Roberts, E., Yamamoto, K., Blonska, A., Ghosh, S. K., Ueda, K., & Zhou, J. (2012) · Progress in Retinal and Eye Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 392

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

Zhou, J., Jang, Y. P., Kim, S. R., & Sparrow, J. R. (2006) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 358

A2E, a byproduct of the visual cycle

Sparrow, J. R., Fishkin, N., Zhou, J., Cai, B., Jang, Y. P., Krane, S., Itagaki, Y., & Nakanishi, K. (2003) · Vision Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 318

Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

Allocca, M., Doria, M., Petrillo, M., Colella, P., Garcia-Hoyos, M., Gibbs, D., Kim, S. R., Maguire, A., Rex, T. S., Di Vicino, U., et al. (2008) · Journal of Clinical Investigation

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 292

The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane

Liu, J., Itagaki, Y., Ben-Shabat, S., Nakanishi, K., & Sparrow, J. R. (2000) · Journal of Biological Chemistry

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 255

SOD2 knockdown mouse model of early AMD

Justilien, V., Pang, J.-J., Renganathan, K., Zhan, X., Crabb, J. W., Kim, S. R., Sparrow, J. R., Hauswirth, W. W., & Lewin, A. S. (2007) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 234

CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium

Ryeom, S. W., Sparrow, J. R., & Silverstein, R. L. (1996) · Journal of Cell Science

Phagocytosis and Immune RegulationRetinal Diseases and Treatments

Cited by 230

Biosynthetic Studies of A2E, a Major Fluorophore of Retinal Pigment Epithelial Lipofuscin

Ben-Shabat, S., Parish, C. A., Vollmer, H. R., Itagaki, Y., Fishkin, N., Nakanishi, K., & Sparrow, J. R. (2002) · Journal of Biological Chemistry

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 214

Phospholipid meets all-trans-retinal: the making of RPE bisretinoids

Sparrow, J. R., Wu, Y., Kim, C. Y., & Zhou, J. (2010) · Journal of Lipid Research

Retinal Diseases and TreatmentsPhotoreceptor and optogenetics research

Cited by 193

Retinal Pigment Epithelium Lipofuscin Proteomics

Ng, K.-P., Gugiu, B., Renganathan, K., Davies, M. W., Gu, X., Crabb, J. S., Kim, S. R., Różanowska, M. B., Bonilha, V. L., Rayborn, M. E., et al. (2008) · Molecular & Cellular Proteomics

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 162

Isolation and characterization of a retinal pigment epithelial cell fluorophore: An all-trans -retinal dimer conjugate

Fishkin, N. E., Sparrow, J. R., Allikmets, R., & Nakanishi, K. (2005) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 146

The all-trans -retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model

Kim, S. R., Jang, Y. P., Jockusch, S., Fishkin, N. E., Turro, N. J., & Sparrow, J. R. (2007) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 145

Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells.

Zhou, J., Cai, B., Jang, Y. P., Pachydaki, S., Schmidt, A. M., & Sparrow, J. R. (2005) · Experimental Eye Research

Retinal Diseases and TreatmentsAdvanced Glycation End Products research

Cited by 113

A1120, a Nonretinoid RBP4 Antagonist, Inhibits Formation of Cytotoxic Bisretinoids in the Animal Model of Enhanced Retinal Lipofuscinogenesis

Dobri, N., Qin, Q., Kong, J., Yamamoto, K., Liu, Z., Moiseyev, G., Ma, J.-X., Allikmets, R., Sparrow, J. R., & Petrukhin, K. (2013) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 91

Rdh12 activity and effects on retinoid processing in the murine retina

Chrispell, J. D., Feathers, K. L., Kane, M. A., Kim, C. Y., Brooks, M., Khanna, R., Kurth, I., Hübner, C. A., Gal, A., Mears, A. J., et al. (2009) · Journal of Biological Chemistry

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 56

Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy

Conley, S. M., Cai, X., Makkia, R., Wu, Y., Sparrow, J. R., & Naash, M. I. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 54

Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells

Damek-Poprawa, M., Diemer, T., Lopes, V. S., Lillo, C., Harper, D. C., Marks, M. S., Wu, Y., Sparrow, J. R., Rachel, R. A., Williams, D. S., et al. (2009) · Journal of Biological Chemistry

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 50

Enzymatic Degradation of A2E, a Retinal Pigment Epithelial Lipofuscin Bisretinoid

Wu, Y., Zhou, J., Fishkin, N., Rittmann, B. E., & Sparrow, J. R. (2011) · Journal of the American Chemical Society

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 50

Persistence of non-viral vector mediated RPE65 expression: Case for viability as a gene transfer therapy for RPE-based diseases

Koirala, A., Conley, S. M., Makkia, R., Liu, Z., Cooper, M. J., Sparrow, J. R., & Naash, M. I. (2013) · Journal of Controlled Release

Retinal Development and DisordersRNA Interference and Gene Delivery

Cited by 47

A2E, a Fluorophore of RPE Lipofuscin: Can It Cause RPE Degeneration?

Sparrow, J. R., Cai, B., Fishkin, N., Jang, Y. P., Krane, S., Vollmer, H. R., Zhou, J., & Nakanishi, K. (2003) · Advances in Experimental Medicine and Biology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 46

Effects of deficiency in the RLBP1-encoded visual cycle protein CRALBP on visual dysfunction in humans and mice

Lima de Carvalho, J. R., Kim, H. J., Ueda, K., Zhao, J., Owji, A. P., Yang, T., Tsang, S. H., & Sparrow, J. R. (2020) · Journal of Biological Chemistry

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 42

Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium

Dhingra, A., Bell, B. A., Peachey, N. S., Daniele, L. L., Reyes-Reveles, J., Sharp, R. C., Jun, B., Bazan, N. G., Sparrow, J. R., Kim, H. J., et al. (2018) · Frontiers in Cellular Neuroscience

Autophagy in Disease and TherapyRetinal Diseases and Treatments

Cited by 41