Drucker, Daniel J.

Never waste a good crisis: confronting reproducibility in translational research

Drucker, D. J. (2016) · Cell Metabolism

Animal testing and alternativesAcademic Publishing and Open Access

Cited by 117

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

Baggio, L. L., Ussher, J. R., McLean, B. A., Cao, X., Kabir, M. G., Mulvihill, E. E., Mighiu, A. S., Zhang, H., Ludwig, A., Seeley, R. J., et al. (2017) · Molecular Metabolism

Diabetes Treatment and ManagementHeart Rate Variability and Autonomic Control

Cited by 117

The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism

Heiss, C. N., Mannerås-Holm, L., Lee, Y. S., Serrano-Lobo, J., Håkansson Gladh, A., Seeley, R. J., Drucker, D. J., Bäckhed, F., & Olofsson, L. E. (2021) · Cell Reports

Regulation of Appetite and ObesityGut microbiota and health

Cited by 114

Antiinflammatory actions of glucagon-like peptide-1–based therapies beyond metabolic benefits

Wong, C. K., & Drucker, D. J. (2025) · Journal of Clinical Investigation

Diabetes Treatment and ManagementAdipokines, Inflammation, and Metabolic Diseases

Cited by 112

Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease

Xiao, Q., Boushey, R. P., Cino, M., Drucker, D. J., & Brubaker, P. L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Inflammatory Bowel DiseaseNeuropeptides and Animal Physiology

Cited by 111

Exendin-4 modulates diabetes onset in nonobese diabetic mice

Hadjiyanni, I., Baggio, L. L., Poussier, P., & Drucker, D. J. (2008) · Endocrinology

Diabetes and associated disordersDiabetes Treatment and Management

Cited by 110

Glucagon‐like peptide‐1 is specifically involved in sweet taste transmission

Takai, S., Yasumatsu, K., Inoue, M., Iwata, S., Yoshida, R., Shigemura, N., Yanagawa, Y., Drucker, D. J., Margolskee, R. F., & Ninomiya, Y. (2015) · The FASEB Journal

Biochemical Analysis and Sensing TechniquesIon Channels and Receptors

Cited by 106

Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action

Varin, E. M., Mulvihill, E. E., Baggio, L. L., Koehler, J. A., Cao, X., Seeley, R. J., & Drucker, D. J. (2019) · Cell Reports

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 104

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis

Mulvihill, E. E., Varin, E. M., Gladanac, B., Campbell, J. E., Ussher, J. R., Baggio, L. L., Yusta, B., Ayala, J., Burmeister, M. A., Matthews, D., et al. (2017) · Cell Metabolism

Diabetes Treatment and ManagementPeptidase Inhibition and Analysis

Cited by 102

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Kim, T., Nason, S., Holleman, C., Pepin, M., Wilson, L., Berryhill, T. F., Wende, A. R., Steele, C., Young, M. E., Barnes, S., et al. (2018) · Diabetes

Fibroblast Growth Factor ResearchDrug Transport and Resistance Mechanisms

Cited by 97

Glucagon-Like Peptide-1 Receptor Knockout Mice Are Protected from High-Fat Diet-Induced Insulin Resistance

Ayala, J. E., Bracy, D. P., James, F. D., Burmeister, M. A., Wasserman, D. H., & Drucker, D. J. (2010) · Endocrinology

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 95

Effects of aging and a high fat diet on body weight and glucose tolerance in glucagon-like peptide-1 receptor -/- mice

Scrocchi, L. A., & Drucker, D. J. (1998) · Endocrinology

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 95

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Findeisen, M., Allen, T. L., Henstridge, D. C., Kammoun, H., Brandon, A. E., Baggio, L. L., Watt, K. I., Pal, M., Cron, L., Estevez, E., et al. (2019) · Nature

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 86

Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide

McLean, B. A., Wong, C. K., Kaur, K. D., Seeley, R. J., & Drucker, D. J. (2021) · JCI Insight

Diabetes Treatment and ManagementAtherosclerosis and Cardiovascular Diseases

Cited by 84

Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction

McLean, B. A., Wong, C. K., Kabir, M. G., & Drucker, D. J. (2022) · Molecular Metabolism

Diabetes Treatment and ManagementCardiac Ischemia and Reperfusion

Cited by 82

GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9

Mantelmacher, F. D., Zvibel, I., Cohen, K., Epshtein, A., Pasmanik-Chor, M., Vogl, T., Kuperman, Y., Weiss, S., Drucker, D. J., Varol, C., et al. (2018) · Nature Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 70

Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

Panaro, B. L., Yusta, B., Matthews, D., Koehler, J. A., Song, Y., Sandoval, D. A., & Drucker, D. J. (2020) · Molecular Metabolism

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 67

Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation

Moschovaki Filippidou, F., Kirsch, A. H., Thelen, M., Kétszeri, M., Artinger, K., Aringer, I., Schabhüttl, C., Mooslechner, A. A., Frauscher, B., Pollheimer, M., et al. (2020) · The American Journal of Pathology

Diabetes Treatment and ManagementChronic Kidney Disease and Diabetes

Cited by 66

Glucagon-like peptide-1 (GLP-1) receptor agonists, obesity and psoriasis: diabetes meets dermatology

Drucker, D. J., & Rosen, C. F. (2011) · Diabetologia

Diabetes Treatment and ManagementPsoriasis: Treatment and Pathogenesis

Cited by 66

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose

Burmeister, M. A., Ayala, J., Drucker, D. J., & Ayala, J. E. (2013) · American Journal of Physiology-Endocrinology and Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 64

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology

Drucker, D. J. (2016) · The Journal of Clinical Endocrinology & Metabolism

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 63

Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY

Schonhoff, S., Baggio, L., Ratineau, C., Ray, S. K., Lindner, J., Magnuson, M. A., Drucker, D. J., & Leiter, A. B. (2005) · Molecular and Cellular Biology

Pancreatic function and diabetesRegulation of Appetite and Obesity

Cited by 53

Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease

Wang, M.-Y., Zhang, Z., Zhao, S., Onodera, T., Sun, X.-N., Zhu, Q., Li, C., Li, N., Chen, S., Paredes, M., et al. (2024) · Cell Metabolism

Chronic Kidney Disease and DiabetesAcute Kidney Injury Research

Cited by 52

The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice

Forny Germano, L., Koehler, J. A., Baggio, L. L., Cui, F., Wong, C. K., Rittig, N., Cao, X., Matthews, D., & Drucker, D. J. (2024) · Molecular Metabolism

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 50