Tyers, Mike

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science

Fungal and yeast genetics researchBioinformatics and Genomic Networks

Cited by 2,138

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

Oughtred, R., Rust, J., Chang, C., Breitkreutz, B., Stark, C., Willems, A., Boucher, L., Leung, G., Kolas, N., Zhang, F., et al. (2021) · Protein Science

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 1,858

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

Choi, H., Larsen, B., Lin, Z.-Y., Breitkreutz, A., Mellacheruvu, D., Fermin, D., Qin, Z. S., Tyers, M., Gingras, A.-C., & Nesvizhskii, A. I. (2011) · Nature Methods

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 800

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Ejim, L., Farha, M. A., Falconer, S. B., Wildenhain, J., Coombes, B. K., Tyers, M., Brown, E. D., & Wright, G. D. (2011) · Nature Chemical Biology

Antibiotic Resistance in BacteriaMicrobial Natural Products and Biosynthesis

Cited by 525

WD40 repeat domain proteins: a novel target class?

Schapira, M., Tyers, M., Torrent, M., & Arrowsmith, C. H. (2017) · Nature Reviews Drug Discovery

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 335

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, B.-J., Hon, G. C., Myers, C. L., Parsons, A., Friesen, H., Oughtred, R., Tong, A., et al. (2006) · Journal of Biology

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 326

Broadening the horizon – level 2.5 of the HUPO-PSI format for molecular interactions

Kerrien, S., Orchard, S., Montecchi-Palazzi, L., Aranda, B., Quinn, A. F., Vinod, N., Bader, G. D., Xenarios, I., Wojcik, J., Sherman, D., et al. (2007) · BMC Biology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 266

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

Borg, M., Mittag, T., Pawson, T., Tyers, M., Forman-Kay, J. D., & Chan, H. S. (2007) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsElectrostatics and Colloid Interactions

Cited by 245

ProHits: integrated software for mass spectrometry–based interaction proteomics

Liu, G., Zhang, J., Larsen, B., Stark, C., Breitkreutz, A., Lin, Z.-Y., Breitkreutz, B.-J., Ding, Y., Colwill, K., Pasculescu, A., et al. (2010) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 243

Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination

Tang, X., Orlicky, S., Lin, Z., Willems, A., Neculai, D., Ceccarelli, D., Mercurio, F., Shilton, B. H., Sicheri, F., & Tyers, M. (2007) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 209

Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

Spitzer, M., Griffiths, E., Blakely, K. M., Wildenhain, J., Ejim, L., Rossi, L., De Pascale, G., Curak, J., Brown, E., Tyers, M., et al. (2011) · Molecular Systems Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 183

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex

Chagraoui, J., Girard, S., Spinella, J.-F., Simon, L., Bonneil, E., Mayotte, N., MacRae, T., Coulombe-Huntington, J., Bertomeu, T., Moison, C., et al. (2021) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 93

Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast

Ericson, E., Gebbia, M., Heisler, L. E., Wildenhain, J., Tyers, M., Giaever, G., & Nislow, C. (2008) · PLoS Genetics

Fungal and yeast genetics researchComputational Drug Discovery Methods

Cited by 89

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

Robbins, N., Spitzer, M., Yu, T., Cerone, R. P., Averette, A. K., Bahn, Y.-S., Heitman, J., Sheppard, D. C., Tyers, M., & Wright, G. D. (2015) · Cell Reports

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 78

Structural basis for the recruitment of glycogen synthase by glycogenin

Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., et al. (2014) · Proceedings of the National Academy of Sciences

Glycogen Storage Diseases and MyoclonusMetabolism, Diabetes, and Cancer

Cited by 57

Expression of the Protein Kinase C Substrate Pleckstrin in Macrophages: Association with Phagosomal Membranes

Brumell, J. H., Howard, J. C., Craig, K., Grinstein, S., Schreiber, A. D., & Tyers, M. (1999) · The Journal of Immunology

Phagocytosis and Immune RegulationCellular transport and secretion

Cited by 54

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function

Robbins, N., Spitzer, M., Wang, W., Waglechner, N., Patel, D. J., O’Brien, J. S., Ejim, L., Ejim, O., Tyers, M., & Wright, G. D. (2016) · Cell Chemical Biology

Microbial Natural Products and BiosynthesisFungal Infections and Studies

Cited by 41

CLMSVault: A software suite for protein cross-linking mass-spectrometry data analysis and visualization

Courcelles, M., Coulombe-Huntington, J., Cossette, É., Gingras, A.-C., Thibault, P., & Tyers, M. (2017) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 21

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

Papadopoli, D., Palia, R., Jovanovic, P., Tabariès, S., Ciccolini, E., Sabourin, V., Igelmann, S., McLaughlan, S., Zhan, L., Kim, H., et al. (2026) · eLife

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 1