Fiorucci, Stefano

6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

Pellicciari, R., Fiorucci, S., Camaioni, E., Clerici, C., Costantino, G., Maloney, P. R., Morelli, A., Parks, D. J., & Willson, T. M. (2002) · Journal of Medicinal Chemistry

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 743

The bile acid receptor FXR is a modulator of intestinal innate immunity

Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2009) · The Journal of Immunology

Inflammatory Bowel DiseaseDrug Transport and Resistance Mechanisms

Cited by 655

Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

Fiorucci, S., & Distrutti, E. (2015) · Trends in Molecular Medicine

Gut microbiota and healthDrug Transport and Resistance Mechanisms

Cited by 539

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., & Morelli, A. (2004) · Gastroenterology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 472

The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

Cipriani, S., Mencarelli, A., Chini, M. G., Distrutti, E., Renga, B., Bifulco, G., Baldelli, F., Donini, A., & Fiorucci, S. (2011) · PLoS ONE

Inflammatory Bowel DiseaseDrug Transport and Resistance Mechanisms

Cited by 382

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

Biagioli, M., Carino, A., Cipriani, S., Francisci, D., Marchianò, S., Scarpelli, P., Sorcini, D., Zampella, A., & Fiorucci, S. (2017) · The Journal of Immunology

Inflammatory Bowel DiseaseGut microbiota and health

Cited by 327

Gut microbiota role in irritable bowel syndrome: New therapeutic strategies

Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology

Gastrointestinal motility and disordersGut microbiota and health

Cited by 320

Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat

Wallace, J. L., Caliendo, G., Santagada, V., Cirino, G., & Fiorucci, S. (2007) · Gastroenterology

Inflammatory mediators and NSAID effectsSulfur Compounds in Biology

Cited by 271

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

Distrutti, E., O’Reilly, J.-A., McDonald, C., Cipriani, S., Renga, B., Lynch, M. A., & Fiorucci, S. (2014) · PLoS ONE

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 237

A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis

Fiorucci, S., Rizzo, G., Antonelli, E., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pruzanski, M., Morelli, A., & Pellicciari, R. (2005) · The Journal of Pharmacology and Experimental Therapeutics

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 183

The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis

Mencarelli, A., Renga, B., Migliorati, M., Cipriani, S., Distrutti, E., Santucci, L., & Fiorucci, S. (2009) · The Journal of Immunology

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 177

Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis

Fiorucci, S., Rizzo, G., Antonelli, E., Renga, B., Mencarelli, A., Riccardi, L., Morelli, A., Pruzanski, M., & Pellicciari, R. (2005) · The Journal of Pharmacology and Experimental Therapeutics

Liver physiology and pathologyPeroxisome Proliferator-Activated Receptors

Cited by 177

5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5 H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

Distrutti, E., Sediari, L., Mencarelli, A., Renga, B., Orlandi, S., Russo, G., Caliendo, G., Santagada, V., Cirino, G., Wallace, J. L., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics

Gastrointestinal motility and disordersPain Mechanisms and Treatments

Cited by 144

Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome

Distrutti, E., Cipriani, S., Mencarelli, A., Renga, B., & Fiorucci, S. (2013) · PLoS ONE

Gastrointestinal motility and disordersProbiotics and Fermented Foods

Cited by 107

Bile acids activated receptors in inflammatory bowel disease

Biagioli, M., Marchianò, S., Carino, A., Di Giorgio, C., Santucci, L., Distrutti, E., & Fiorucci, S. (2021) · Cells

Gut microbiota and healthDrug Transport and Resistance Mechanisms

Cited by 103

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts

Renga, B., Mencarelli, A., Migliorati, M., Cipriani, S., D’Amore, C., Distrutti, E., & Fiorucci, S. (2011) · Inflammation Research

Liver physiology and pathologyPeroxisome Proliferator-Activated Receptors

Cited by 53

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Biagioli, M., Marchianò, S., di Giorgio, C., Roselli, R., Bordoni, M., Bellini, R., Fiorillo, B., Sepe, V., Catalanotti, B., Cassiano, C., et al. (2023) · Hepatology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 28

Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis

Cipriani, S., Carino, A., Masullo, D., Zampella, A., Distrutti, E., & Fiorucci, S. (2017) · Scientific Reports

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 16