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Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

Distrutti, Eleonora, O’Reilly, Julie-Ann, McDonald, Claire, Cipriani, Sabrina, Renga, Barbara, Lynch, Marina A., Fiorucci, Stefano·2014·PLoS ONE
DOI 10.1371/journal.pone.0106503PMC PMC4159266
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  • VSL#3 acts as an anti-inflammatory in the mouse gut, mirrored in the brain by a reduction in CD11b and CD68 mRNA expression in the hippocampus in VSL#3-treated aged rats.

    “This is consistent with the fact that VSL#3 acted as an anti-inflammatory in the mouse gut, which was mirrored in the brain, as noted by a reduction in CD11b and CD68 mRNA expression (two markers of microglial activation) in the hippocampus in VSL#3-treated aged rats (Distrutti et al., 2014).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Distrutti et al., 2014

  • VSL#3 increases hippocampal BDNF and synapsin expression, suggesting a neuro-synaptotrophic effect.

    “Here, they witnessed an increase in hippocampal BDNF and synapsin expression, suggesting that VSL#3 exerted a neuro-synaptotrophic effect.”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Distrutti et al., 2014

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Authors
Distrutti, E., O’Reilly, J.-A., McDonald, C., Cipriani, S., Renga, B., Lynch, M. A., & Fiorucci, S.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-09-09
Volume
9
Issue
9
Pages
e106503
ISSN
1932-6203
DOI
10.1371/journal.pone.0106503
PMC
PMC4159266
Cited by
207
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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