Schalkwyk, Leonard C.

A data-driven approach to preprocessing Illumina 450K methylation array data

Pidsley, R., Y Wong, C. C., Volta, M., Lunnon, K., Mill, J., & Schalkwyk, L. C. (2013) · BMC Genomics

Epigenetics and DNA MethylationGene expression and cancer classification

Cited by 1,143

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,025

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

De Jager, P. L., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, L. C., Yu, L., Eaton, M. L., Keenan, B. T., Ernst, J., McCabe, C., et al. (2014) · Nature Neuroscience

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

Cited by 956

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 630

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., et al. (2014) · Nature Neuroscience

Epigenetics and DNA MethylationAlzheimer's disease research and treatments

Cited by 574

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., et al. (2021) · Nature Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 506

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 460

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes

Hannon, E., Lunnon, K., Schalkwyk, L., & Mill, J. (2015) · Epigenetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 455

An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation

Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, A. R., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., et al. (2016) · Genome Biology

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 349

Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

Wong, C. C. Y., Meaburn, E. L., Ronald, A., Price, T. S., Jeffries, A. R., Schalkwyk, L. C., Plomin, R., & Mill, J. (2014) · Molecular Psychiatry

Autism Spectrum Disorder ResearchEpigenetics and DNA Methylation

Cited by 327

Methylomic trajectories across human fetal brain development

Spiers, H., Hannon, E., Schalkwyk, L. C., Smith, R., Wong, C. C. Y., O’Donovan, M. C., Bray, N. J., & Mill, J. (2015) · Genome Research

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 287

Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans

Houtepen, L. C., Vinkers, C. H., Carrillo-Roa, T., Hiemstra, M., van Lier, P. A., Meeus, W., Branje, S., Heim, C. M., Nemeroff, C. B., Mill, J., et al. (2016) · Nature Communications

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 242

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

Marzi, S. J., Leung, S. K., Ribarska, T., Hannon, E., Smith, A. R., Pishva, E., Poschmann, J., Moore, K., Troakes, C., Al-Sarraj, S., et al. (2018) · Nature Neuroscience

Alzheimer's disease research and treatmentsGenomics and Chromatin Dynamics

Cited by 232

Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder

Boks, M. P., Mierlo, H. C. V., Rutten, B. P. F., Radstake, T. R. D. J., De Witte, L., Geuze, E., Horvath, S., Schalkwyk, L. C., Vinkers, C. H., Broen, J. C. A., et al. (2015) · Psychoneuroendocrinology

Posttraumatic Stress Disorder ResearchTelomeres, Telomerase, and Senescence

Cited by 231

Mitochondrial genes are altered in blood early in Alzheimer's disease

Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., et al. (2017) · Neurobiology of Aging

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 190

Elevated DNA methylation across a 48‐kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

Smith, R. G., Hannon, E., De Jager, P. L., Chibnik, L., Lott, S. J., Condliffe, D., Smith, A. R., Haroutunian, V., Troakes, C., Al‐Sarraj, S., et al. (2018) · Alzheimer's & Dementia

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

Cited by 184

Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex

Abdel-Majid, R. M., Leong, W. L., Schalkwyk, L. C., Smallman, D. S., Wong, S. T., Storm, D. R., Fine, A., Dobson, M. J., Guernsey, D. L., & Neumann, P. E. (1998) · Nature Genetics

Neurogenesis and neuroplasticity mechanismsTactile and Sensory Interactions

Cited by 163

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia

Pidsley, R., Viana, J., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, L. C., Bray, N. J., et al. (2014) · Genome biology

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 157

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., de Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A. E., et al. (2018) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchEpigenetics and DNA Methylation

Cited by 142

Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

Janecka, M., Mill, J., Basson, M. A., Goriely, A., Spiers, H., Reichenberg, A., Schalkwyk, L., & Fernandes, C. (2017) · Translational Psychiatry

Autism Spectrum Disorder ResearchSperm and Testicular Function

Cited by 140

Maternal separation is associated with strain‐specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse

Kember, R. L., Dempster, E. L., Lee, T. H. A., Schalkwyk, L. C., Mill, J., & Fernandes, C. (2012) · Brain and Behavior

Stress Responses and CortisolNeuroendocrine regulation and behavior

Cited by 133

Allele-specific methylation in the human genome: Implications for genetic studies of complex disease

Meaburn, E. L., Schalkwyk, L. C., & Mill, J. (2010) · Epigenetics

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 132

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

Condliffe, D., Wong, A., Troakes, C., Proitsi, P., Patel, Y., Chouliaras, L., Fernandes, C., Cooper, J., Lovestone, S., Schalkwyk, L., et al. (2014) · Neurobiology of Aging

Epigenetics and DNA MethylationAlzheimer's disease research and treatments

Cited by 131

Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men

Kas, M. J. H., Fernandes, C., Schalkwyk, L. C., & Collier, D. A. (2007) · Molecular Psychiatry

Neurotransmitter Receptor Influence on BehaviorGenetic Associations and Epidemiology

Cited by 122