Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men
Abstract
Family and twin studies have revealed that genetic factors play a major role in psychiatric disorders, however, attempts to find susceptibility genes for these complex disorders have been largely unsuccessful. Therefore, new research strategies are required to tackle the complex interactions of genes, developmental, and environmental events. Here, we will address a behavioural domain concept that focuses on the genetics of behavioural domains relevant to both animal behaviour and across human psychiatric disorders. We believe that interspecies trait genetics rather than complex syndrome genetics will optimize genotype-phenotype relationships for psychiatric disorders and facilitate the identification of biological substrates underlying these disorders.
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This may be due to high specialization and diverse strategies for ethologically relevant social behaviors in mammals, particularly primates.
“This may be due to the high degree of specialization and diverse strategies for ethologically relevant social behaviors in mammals, particularly primates (Bucan and Abel, 2002; Flint and Mott, 2008; Kas et al., 2007).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Kas et al., 2007
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- Authors
- Kas, M. J. H., Fernandes, C., Schalkwyk, L. C., & Collier, D. A.
- Affiliations
- University Medical Center Utrecht (NL)
- King's College London (GB)
- Corresponding author
- Kas, M J H
- Venue
- Molecular Psychiatry
- Published
- 2006-11-21
- Volume
- 12
- Issue
- 4
- Pages
- 324-330
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1969242600
- Cited by
- 122
- References
- 56
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 14 · 2012: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Open Access at Essex (University of Essex) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- mental illness, genetic susceptibility, genotype-phenotype correlation, gene-environment interaction, twin and family studies
- MeSH terms
- Animals, Behavior, Animal, Mental Disorders, Chromosome Mapping, Disease Models, Animal, Environment, Genetics, Behavioral, Humans, Phenotype, Mice
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