Brough, David

Understanding the mechanism of IL-1β secretion

Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews

Inflammasome and immune disordersImmune Response and Inflammation

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Consensus guidelines for the detection of immunogenic cell death

Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology

Immunotherapy and Immune ResponsesCell death mechanisms and regulation

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., et al. (2014) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 790

Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

Brough, D., & Rothwell, N. J. (2007) · Journal of Cell Science

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 265

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

Savage, C. D., Lopez-Castejon, G., Denes, A., & Brough, D. (2012) · Frontiers in Immunology

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

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The NLRP3–inflammasome as a sensor of organelle dysfunction

Seoane, P. I., Lee, B., Hoyle, C., Yu, S., Lopez-Castejon, G., Lowe, M., & Brough, D. (2020) · Journal of Cell Biology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 190

Anti-inflammatories in Alzheimer’s disease—potential therapy or spurious correlate?

Rivers-Auty, J., Mather, A. E., Peters, R., Lawrence, C. B., & Brough, D. (2020) · Brain Communications

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Microglial Priming as Trained Immunity in the Brain

Haley, M. J., Brough, D., Quintin, J., & Allan, S. M. (2019) · Neuroscience

Immune responses and vaccinationsNeuroinflammation and Neurodegeneration Mechanisms

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Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo

Corbett, D., Wang, J., Schuler, S., Lopez-Castejon, G., Glenn, S., Brough, D., Andrew, P. W., Cavet, J. S., & Roberts, I. S. (2012) · Infection and Immunity

Listeria monocytogenes in Food SafetyBacterial Genetics and Biotechnology

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Interleukin-1α and brain inflammation

Brough, D., & Denes, A. (2015) · IUBMB Life

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 54

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Dewhurst, M. R., Ow, J. R., Zafer, G., van Hul, N. K. M., Wollmann, H., Bisteau, X., Brough, D., Choi, H., & Kaldis, P. (2020) · PLOS Genetics

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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