Interleukin-1α and brain inflammation

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works

Activation and regulation of the inflammasomes

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The Calpain System

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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

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Non-canonical inflammasome activation targets caspase-11

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Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works

Molecular mechanisms of necroptosis: an ordered cellular explosion

Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

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Identification of RIP1 kinase as a specific cellular target of necrostatins

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The interleukin-1 family: back to the future

Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · see citing works

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931 · see citing works

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

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Understanding the mechanism of IL-1β secretion

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Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

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DAMPening Inflammation by Modulating TLR Signalling

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The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

Wang, Z., Jiang, H., Chen, S., Du, F., & Wang, X. (2012) · Cell · doi:10.1016/j.cell.2011.11.030 · Cited by 949 · see citing works

The Sterile Inflammatory Response

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Inflammasomes in the CNS

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The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress

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Inflammation in neurodegenerative diseases—An update

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IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

Rider, P., Carmi, Y., Guttman, O., Braiman, A., Cohen, I., Voronov, E., White, M. R., Dinarello, C. A., & Apte, R. N. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102048 · Cited by 522 · see citing works

Role of IL-1α and IL-1β in Ischemic Brain Damage

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Identification of a membrane-associated interleukin 1 in macrophages.

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Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

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Programmed necrosis: backup to and competitor with apoptosis in the immune system

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The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

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Differential release of chromatin-bound IL-1α discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

Cohen, I., Rider, P., Carmi, Y., Braiman, A., Dotan, S., White, M. R., Voronov, E., Martin, M. U., Dinarello, C. A., & Apte, R. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915018107 · Cited by 327 · see citing works

Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation

Dénes, Á., Thornton, P., Rothwell, N. J., & Allan, S. M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.010 · Cited by 307 · see citing works

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T., Iwakura, Y., Hersberger, M., & Köpf, M. (2013) · Nature Immunology · doi:10.1038/ni.2704 · Cited by 304 · see citing works

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

Bossaller, L., Chiang, P.-I., Schmidt‐Lauber, C., Ganesan, S., Kaiser, W. J., Rathinam, V. A. K., Mocarski, E. S., Subramanian, D., Green, D. R., Silverman, N. S., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202121 · Cited by 287 · see citing works

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

Afonina, I. S., Tynan, G. A., Logue, S. E., Cullen, S. P., Bots, M. L., Lüthi, A. U., Reeves, E. P., McElvaney, N. G., Medema, J. P., Lavelle, E. C., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.037 · Cited by 275 · see citing works

Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

Brough, D., & Rothwell, N. J. (2007) · Journal of Cell Science · doi:10.1242/jcs.03377 · Cited by 265 · see citing works

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

Fortes, G. B., Alves, L. S., de Oliveira, R., Dutra, F. F., Rodrigues, D., Fernandez, P. L., Souto-Padron, T., De Rosa, M. J., Kelliher, M., Golenbock, D., et al. (2012) · Blood · doi:10.1182/blood-2011-08-375303 · Cited by 246 · see citing works

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

Allen, C., Thornton, P., Dénes, Á., McColl, B. W., Pierozynski, A., Monestier, M., Pinteaux, E., Rothwell, N. J., & Allan, S. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200409 · Cited by 245 · see citing works

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

Eigenbrod, T., Park, J.-H., Harder, J., Iwakura, Y., & Núñez, G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8194 · Cited by 228 · see citing works

The calpains: modular designs and functional diversity

Croall, D. E., & Ersfeld, K. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-218 · Cited by 221 · see citing works

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation: Effects of Hyperlipidemia-Mediated Inhibition of Phagocytosis

Clarke, M. C. H., Talib, S., Figg, N. L., & Bennett, M. R. (2010) · Circulation Research · doi:10.1161/circresaha.109.208389 · Cited by 216 · see citing works

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

Kim, B., Lee, Y. M., Kim, E., Kwak, A., Ryoo, S., Bae, S. H., Azam, T., Kim, S., & Dinarello, C. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00391 · Cited by 216 · see citing works

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

Zheng, Y., Humphry, M., Maguire, J. J., Bennett, M. R., & Clarke, M. C. H. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.008 · Cited by 205 · see citing works

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

Northington, F. J., Chavez‐Valdez, R., Graham, E. M., Razdan, S., Gauda, E. B., & Martin, L. J. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.72 · Cited by 205 · see citing works

Overview of the interleukin-1 family of ligands and receptors

Dinarello, C. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.001 · Cited by 198 · see citing works

Inflammation in Human Brain Injury: Intracerebral Concentrations of IL-1 α , IL-1 β , and Their Endogenous Inhibitor IL-1ra

Hutchinson, P. J., O’Connell, M. T., Rothwell, N. J., Hopkins, S. J., Nortje, J., Carpenter, K. L. H., Timofeev, I. S., Al-Rawi, P. G., Menon, D. K., & Pickard, J. D. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0295 · Cited by 185 · see citing works

Delayed administration of interleukin‐1 receptor antagonist protects against transient cerebral ischaemia in the rat

MULCAHY, N., Ross, J., Rothwell, N. J., & Loddick, S. A. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705462 · Cited by 185 · see citing works

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

Casson, C. N., Copenhaver, A. M., Zwack, E. E., Nguyen, H. T., Strowig, T., Javdan, B., Bradley, W. P., Fung, T. C., Flavell, R. A., Brodsky, I. E., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003400 · Cited by 178 · see citing works

Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression

Fettelschoss‐Gabriel, A., Kistowska, M., LeibundGut‐Landmann, S., Beer, H., Johansen, P., Senti, G., Contassot, E., Bachmann, M. F., French, L. E., Oxenius, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109176108 · Cited by 169 · see citing works

Platelet interleukin-1α drives cerebrovascular inflammation

Thornton, P., McColl, B. W., Greenhalgh, A. D., Dénes, Á., Allan, S. M., & Rothwell, N. J. (2010) · Blood · doi:10.1182/blood-2009-11-252643 · Cited by 163 · see citing works

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

Dénes, Á., Ferenczi, S., & Kovács, K. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-164 · Cited by 162 · see citing works

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

Lukens, J. R., Vogel, P., Johnson, G. R., Kelliher, M. A., Iwakura, Y., Lamkanfi, M., & Kanneganti, T. (2013) · Nature · doi:10.1038/nature12174 · Cited by 157 · see citing works

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

England, H., Summersgill, H. R., Edye, M. E., Rothwell, N. J., & Brough, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.557561 · Cited by 151 · see citing works

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

Luheshi, N., Kovács, K., López‐Castejón, G., Brough, D., & Dénes, Á. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-186 · Cited by 138 · see citing works

Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor

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Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

Pradillo, J. M., Dénes, Á., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., Barton, E. C., Proctor, S. D., Russell, J. C., Rothwell, N. J., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.101 · Cited by 130 · see citing works

IL-1α, IL-1β, and IFN-γ mark β cells for Fas-dependent destruction by diabetogenic CD4+ T lymphocytes

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Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

Dénes, Á., Humphreys, N. E., Lane, T. E., Grencis, R. K., & Rothwell, N. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1227-10.2010 · Cited by 129 · see citing works

Influenza virus infection aggravates stroke outcome

Muhammad, S., Haasbach, E., Kotchourko, M., Strigli, A., Krenz, A., Ridder, D. A., Vogel, A. B., Marti, H. H., Al-Abed, Y., Planz, O., et al. (2011) · Stroke · doi:10.1161/strokeaha.110.596783 · Cited by 116 · see citing works

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells

Antonopoulos, C. H., Sanadi, C. E. E., Kaiser, W. J., Mocarski, E. S., & Dubyak, G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300645 · Cited by 114 · see citing works

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

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Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

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Interleukin-1α Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes

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Membrane IL-1: IL-1 alpha precursor binds to the plasma membrane via a lectin-like interaction.

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Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes

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Post-translational processing of murine IL-1: evidence that ATP-induced release of IL-1 alpha and IL-1 beta occurs via a similar mechanism.

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S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

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Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme

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Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

Carta, S., Lavieri, R., & Rubartelli, A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00123 · Cited by 86 · see citing works

Dual functionality of interleukin‐1 family cytokines: implications for anti‐interleukin‐1 therapy

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Post-Translational Processing of Murine IL-1: Evidence that ATP-Induced Release of IL-1α and IL-1β Occurs via a Similar Mechanism

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Caspase‐11: The driving factor for noncanonical inflammasomes

Viganò, E., & Mortellaro, A. (2013) · European Journal of Immunology · doi:10.1002/eji.201343800 · Cited by 82 · see citing works

Sustained IL-1α, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus

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Systemic inflammation and stroke: aetiology, pathology and targets for therapy

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Vasospasm in Cerebral Inflammation

Eisenhut, M. (2014) · International Journal of Inflammation · doi:10.1155/2014/509707 · Cited by 65 · see citing works

The role of inflammation and interleukin-1 in acute cerebrovascular disease

Brough, D., & Galea, J. P. (2013) · Journal of Inflammation Research · doi:10.2147/jir.s35629 · Cited by 61 · see citing works

Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

Dénes, Á., Pradillo, J. M., Drake, C., Sharp, J., Warn, P. A., Murray, K. N., Bazaz, R., Dockrell, D. H., Chamberlain, J., Casbolt, H. L., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24146 · Cited by 59 · see citing works

Systemic Inflammation Impairs Tissue Reperfusion Through Endothelin-Dependent Mechanisms in Cerebral Ischemia

Murray, K. N., Girard, S., Holmes, W. M., Parkes, L. M., Williams, S. R., Parry‐Jones, A., & Allan, S. M. (2014) · Stroke · doi:10.1161/strokeaha.114.006613 · Cited by 53 · see citing works

Nuclear retention of IL‐1α by necrotic cells: A mechanism to dampen sterile inflammation

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Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

Dhungana, H., Malm, T., Dénes, Á., Valonen, P. K., Wojciechowski, S., Magga, J. M., Savchenko, E., Humphreys, N. E., Grencis, R. K., Rothwell, N. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12106 · Cited by 44 · see citing works

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

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Secretion of adipocytokines by perivascular adipose tissue near stenotic and non-stenotic coronary artery segments in patients undergoing CABG

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A World of Chronic Disease

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Changes in Interleukin-1 alpha serum levels after transplantation of umbilical cord blood cells in a model of perinatal hypoxic-ischemic brain damage

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Intracellular il-1 receptor 2 binding prevents cleavage and activity of IL-1ALPHA, controlling necrosis-induced sterile inflammation

Zheng, Y., Humphry, M., Maguire, J. J., Bennett, M. R., & Clarke, M. C. H. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.023 · Cited by 18 · see citing works

Global Indicators and Targets for Noncommunicable Diseases

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Release of IL-1alpha or IL-1beta depends on mechanism of cell death

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Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

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Additional file 7 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615145

Epileptogenesis in Posttraumatic Epilepsy

Ngadimon, I. W., Zulazmi, N. A., & Shaikh, M. F. (2024) · Springer eBooks · doi:10.1007/978-981-99-7557-0_20

Additional file 6 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615142

Additional file 1 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615124

Additional file 4 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615136

Additional file 2 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615130

Additional file 5 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615139

Additional file 3 of Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Zhu, D., Zhang, J., Hashem, J., Gao, F., & Chen, C. (2023) · Figshare · doi:10.6084/m9.figshare.22615133

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