Consensus guidelines for the detection of immunogenic cell death
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and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine.
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ICD is sufficient to activate an adaptive immune response specific for endogenous or exogenous antigens expressed by dying cells.
“Immunogenic cell death (ICD) is a functionally peculiar form of RCD that is sufficient to activate an adaptive immune response specific for endogenous (cellular) or exogenous (viral) antigens expressed by dying cells [852, 853].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [853]
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Self-citationHMGB1 is an endogenous immune adjuvant released by necrotic cells
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Self-citationThe Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
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Molecular mechanisms of ATP secretion during immunogenic cell death
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Self-citationCell death assays for drug discovery
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Self-citationMitochondrial Control of Cellular Life, Stress, and Death
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Self-citationHyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4
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Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
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Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
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Self-citationCD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
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Self-citationRAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages
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Liaisons dangereuses: P2X7 and the inflammasome
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HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
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Self-citationAutophagy and cellular immune responses
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Self-citationA dual role for autophagy in a murine model of lung cancer
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Self-citationAn Immunosurveillance Mechanism Controls Cancer Cell Ploidy
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Self-citationCardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
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The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.
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Self-citationPivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors
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Self-citationOncolytic viruses as therapeutic cancer vaccines
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Self-citationATP release and purinergic signaling in NLRP3 inflammasome activation
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ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
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Self-citationMolecular determinants of immunogenic cell death elicited by anticancer chemotherapy
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Self-citationMany faces of DAMPs in cancer therapy
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Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity
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Molecular mechanisms of regulated necrosis
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Self-citationTrial watch: FDA-approved Toll-like receptor agonists for cancer therapy
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Methods for Assessing Autophagy and Autophagic Cell Death
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Self-citationRelease of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death
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Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
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Self-citation
- Authors
- Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., Bracci, L., Breckpot, K., Brough, D., Buqué, A., Castro, M. G., Cirone, M., Colombo, M. I., Cremer, I., Demaria, S., Dini, L., Eliopoulos, A. G., Faggioni, A., Formenti, S. C., Fučíková, J., Gabriele, L., Gaipl, U. S., Galon, J., Garg, A., Ghiringhelli, F., Giese, N. A., Guo, Z. S., Hemminki, A., Herrmann, M., Hodge, J. W., Holdenrieder, S., Honeychurch, J., Hu, H.-M., Huang, X., Illidge, T. M., Kono, K., Korbelik, M., Krysko, D. V., Loi, S., Lowenstein, P. R., Lugli, E., Ma, Y., Madeo, F., Manfredi, A. A., Martins, I., Mavilio, D., Menger, L., Merendino, N., Michaud, M., Mignot, G., Mossman, K. L., Multhoff, G., Oehler, R., Palombo, F., Panaretakis, T., Pol, J., Proietti, E., Ricci, J.-E., Riganti, C., Rovere-Querini, P., Rubartelli, A., Sistigu, A., Smyth, M. J., Sonnemann, J., Spisek, R., Stagg, J., Sukkurwala, A. Q., Tartour, E., Thorburn, A., Thorne, S. H., Vandenabeele, P., Velotti, F., Workenhe, S. T., Yang, H., Zong, W.-X., Zitvogel, L., Kroemer, G., & Galluzzi, L.
- Affiliations
- Inserm (FR)
- Instituto Nazionale Tumori Regina Elena (IT)
- KU Leuven (BE)
- Istituto Pasteur (IT)
- Istituto Superiore di Sanità (IT)
- Université Libre de Bruxelles (BE)
- University of Manchester (GB)
- University of Michigan (US)
- Sapienza University of Rome (IT)
- New York University (US)
- University of Salento (IT)
- University of Crete (GR)
- NYU Langone Health (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Heidelberg (DE)
- University of Pittsburgh (US)
- University of Helsinki (FI)
- National Institutes of Health (US)
- University Hospital Bonn (DE)
- Manchester Academic Health Science Centre (GB)
- National University of Singapore (SG)
- BC Cancer Agency (CA)
- Ghent University (BE)
- Peter MacCallum Cancer Centre (AU)
- University of Milan (IT)
- University of Graz (AT)
- Vita-Salute San Raffaele University (IT)
- Université Paris-Sud (FR)
- Università degli Studi della Tuscia (IT)
- McMaster University (CA)
- TUM Klinikum (DE)
- Comprehensive Cancer Center Vienna (AT)
- Karolinska Institutet (SE)
- University of Turin (IT)
- Ospedale Policlinico San Martino (IT)
- The University of Queensland (AU)
- Jena University Hospital (DE)
- Centre Hospitalier de l’Université de Montréal (CA)
- University of Colorado Anschutz (US)
- University of Hawaii Cancer Center (US)
- Stony Brook University (US)
- Corresponding author
- Galluzzi, Lorenzo
- ORCID
- Kepp, Oliver
- Senovilla, Laura
- Vitale, Ilio
- Vacchelli, Erika
- Adjemian, Sandy
- Agostinis, Patrizia
- Aranda, Fernando
- Barnaba, Vincenzo
- Bloy, Norma
- Bracci, Laura
- Breckpot, Karine
- Brough, David
- Buqué, Aitziber
- Castro, Maria G.
- Cirone, Mara
- Cremer, Isabelle
- Demaria, Sandra
- Eliopoulos, Aristides G.
- Faggioni, Alberto
- Formenti, Silvia C.
- Gabriele, Lucia
- Gaipl, Udo S.
- Galon, Jérôme
- Garg, Abhishek
- Ghiringhelli, François
- Giese, Nathalia A.
- Guo, Zong Sheng
- Hemminki, Akseli
- Hodge, James W.
- Holdenrieder, Stefan
- Honeychurch, Jamie
- Huang, Xing
- Illidge, Tim M.
- Kono, Koji
- Korbelik, Mladen
- Krysko, Dmitri V.
- Loi, Sherene
- Lowenstein, Pedro R.
- Lugli, Enrico
- Ma, Yuting
- Madeo, Frank
- Manfredi, Angelo A.
- Martins, Isabelle
- Mavilio, Domenico
- Menger, Laurie
- Merendino, Nicolò
- Mossman, Karen L.
- Multhoff, Gabriele
- Oehler, Rudolf
- Palombo, Fabio
- Panaretakis, Theocharis
- Pol, Jonathan
- Proietti, Enrico
- Ricci, Jean-Ehrland
- Riganti, Chiara
- Rubartelli, Anna
- Sistigu, Antonella
- Smyth, Mark J.
- Stagg, John
- Thorburn, Andrew
- Thorne, Stephen H.
- Vandenabeele, Peter
- Velotti, Francesca
- Workenhe, Samuel T.
- Yang, Haining
- Zitvogel, Laurence
- Kroemer, Guido
- Galluzzi, Lorenzo
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2014-09-02
- Volume
- 3
- Issue
- 9
- Pages
- e955691
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC4292729
- OpenAlex
- W2163252162
- Cited by
- 832
- References
- 292
- Citations by year
- 2026: 47 · 2025: 53 · 2024: 44 · 2023: 66 · 2022: 77 · 2021: 95 · 2020: 93 · 2019: 95 · 2018: 63 · 2017: 62 · 2016: 83 · 2015: 48 · 2014: 5 · 2013: 1
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- OncoImmunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UnitusOpen (Tuscia University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- AIRUS (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Cancer Research UK (11335, 17737)
- European Commission
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Fondation de France
- Institut National Du Cancer
- National Institutes of Health (5r01ns082311-05)
- Labex Immuno-Oncology
- National Cancer Institute (R01CA129536)
- National Institute of Neurological Disorders and Stroke (R01NS074387, R01NS061107, R01NS057711, R01-NS082311)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- immunogenic cell death, calreticulin exposure, extracellular ATP, HMGB1, endoplasmic reticulum stress, autophagy, cancer immunotherapy
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