Britton, Sébastien

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P. (2012) · Nature Chemical Biology

DNA and Nucleic Acid ChemistryMetal complexes synthesis and properties

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology

DNA Repair MechanismsHistone Deacetylase Inhibitors Research

Cited by 629

Chemical inhibition of NAT10 corrects defects of laminopathic cells

Larrieu, D., Britton, S., Demir, M., Rodriguez, R., & Jackson, S. P. (2014) · Science

Nuclear Structure and FunctionDNA Repair Mechanisms

Cited by 431

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

Bossaert, M., Pipier, A., Riou, J.-F., Noirot, C., Nguyên, L.-T., Serre, R.-F., Bouchez, O., Defrancq, E., Calsou, P., Britton, S., et al. (2021) · eLife

DNA and Nucleic Acid ChemistryCancer therapeutics and mechanisms

Cited by 97