Engelman, Alan

Identification of host proteins required for HIV infection through a functional genomic screen

Brass, A. L., Dykxhoorn, D. M., Benita, Y., Yan, N., Engelman, A., Xavier, R. J., Lieberman, J., & Elledge, S. J. (2008) · Science

HIV Research and TreatmentVirus-based gene therapy research

Cited by 1,449

Crystal Structure of the Catalytic Domain of HIV-1 Integrase: Similarity to Other Polynucleotidyl Transferases

Dyda, F., Hickman, A. B., Jenkins, T. M., Engelman, A., Craigie, R., & Davies, D. R. (1994) · Science

HIV/AIDS drug development and treatmentEnzyme Structure and Function

Cited by 810

Retroviral intasome assembly and inhibition of DNA strand transfer

Hare, S., Gupta, S. S., Valkov, E., Engelman, A., & Cherepanov, P. (2010) · Nature

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 678

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

Engelman, A., Mizuuchi, K., & Craigie, R. (1991) · Cell

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 655

Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro

Engelman, A., & Craigie, R. (1992) · Journal of Virology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 519

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

Shun, M.-C., Raghavendra, N. K., Vandegraaff, N., Daigle, J. E., Hughes, S., Kellam, P., Cherepanov, P., & Engelman, A. (2007) · Genes & Development

HIV Research and TreatmentVirus-based gene therapy research

Cited by 467

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

Engelman, A., Englund, G., Orenstein, J. M., Martin, M. A., & Craigie, R. (1995) · Journal of Virology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 445

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75

Cherepanov, P., Ambrosio, A. L. B., Rahman, S., Ellenberger, T., & Engelman, A. (2005) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 408

Solution Structure of the DNA Binding Domain of HIV-1 Integrase

Lodi, P. J., Ernst, J. A., Kuszewski, J., Hickman, A. B., Engelman, A., Craigie, R., Clore, G. M., & Gronenborn, A. M. (1995) · Biochemistry

Protein Structure and DynamicsHIV/AIDS drug development and treatment

Cited by 300

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase

Cherepanov, P., Devroe, E., Silver, P. A., & Engelman, A. (2004) · Journal of Biological Chemistry

HIV Research and TreatmentGenomics and Chromatin Dynamics

Cited by 287

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

Matreyek, K. A., Yücel, S. S., Li, X., & Engelman, A. (2013) · PLoS Pathogens

HIV Research and TreatmentNuclear Structure and Function

Cited by 280

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Sowd, G. A., Serrao, E., Wang, H., Wang, W., Fadel, H. J., Poeschla, E. M., & Engelman, A. N. (2016) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentVirus-based gene therapy research

Cited by 249

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Cherepanov, P., Sun, Z.-Y. J., Rahman, S., Maertens, G., Wagner, G., & Engelman, A. (2005) · Nature Structural & Molecular Biology

HIV Research and TreatmentProtein Structure and Dynamics

Cited by 235

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

Engelman, A., & Cherepanov, P. (2008) · PLoS Pathogens

HIV Research and TreatmentVirus-based gene therapy research

Cited by 231

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Achuthan, V., Perreira, J. M., Sowd, G. A., Puray-Chavez, M., McDougall, W. M., Paulucci-Holthauzen, A., Wu, X., Fadel, H. J., Poeschla, E. M., Multani, A. S., et al. (2018) · Cell Host & Microbe

HIV Research and TreatmentVirus-based gene therapy research

Cited by 205

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Jurado, K. A., Wang, H., Slaughter, A., Feng, L., Kessl, J. J., Koh, Y., Wang, W., Ballandras-Colas, A., Patel, P. A., Fuchs, J. R., et al. (2013) · Proceedings of the National Academy of Sciences

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 203

In Vivo Analysis of Retroviral Integrase Structure and Function

Engelman, A. (1999) · Advances in Virus Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 176

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

Hare, S., Shun, M.-C., Gupta, S. S., Valkov, E., Engelman, A., & Cherepanov, P. (2009) · PLoS Pathogens

Virus-based gene therapy researchHIV Research and Treatment

Cited by 166

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Francis, A. C., Marin, M., Singh, P. K., Achuthan, V., Prellberg, M. J., Palermino-Rowland, K., Lan, S., Tedbury, P. R., Sarafianos, S. G., Engelman, A. N., et al. (2020) · Nature Communications

HIV Research and TreatmentVirus-based gene therapy research

Cited by 159

Structural basis for retroviral integration into nucleosomes

Maskell, D. P., Renault, L., Serrao, E., Lesbats, P., Matadeen, R., Hare, S., Lindemann, D., Engelman, A. N., Costa, A., & Cherepanov, P. (2015) · Nature

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 138

Structure and function of retroviral integrase

Maertens, G. N., Engelman, A. N., & Cherepanov, P. (2022) · Nature Reviews Microbiology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 124

Structural Basis for Functional Tetramerization of Lentiviral Integrase

Hare, S., Di Nunzio, F., Labeja, A., Wang, J., Engelman, A., & Cherepanov, P. (2009) · PLoS Pathogens

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 122

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration

Koh, Y., Wu, X., Ferris, A. L., Matreyek, K. A., Smith, S. J., Lee, K., KewalRamani, V. N., Hughes, S. H., & Engelman, A. (2013) · Journal of Virology

HIV Research and TreatmentVirus-based gene therapy research

Cited by 122

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Cook, N. J., Li, W., Berta, D., Badaoui, M., Ballandras-Colas, A., Nans, A., Kotecha, A., Rosta, E., Engelman, A. N., & Cherepanov, P. (2020) · Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 108