Engelman, Alan

A supramolecular assembly mediates lentiviral DNA integration

Ballandras-Colas, A., Maskell, D. P., Serrao, E., Locke, J., Swuec, P., Jónsson, S. R., Kotecha, A., Cook, N. J., Pye, V. E., Taylor, I. A., et al. (2017) · Science

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 107

Multiple Integrase Functions Are Required to Form the Native Structure of the Human Immunodeficiency Virus Type I Intasome

Chen, H., Wei, S.-Q., & Engelman, A. (1999) · Journal of Biological Chemistry

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 103

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Ballandras-Colas, A., Brown, M., Cook, N. J., Dewdney, T. G., Demeler, B., Cherepanov, P., Lyumkis, D., & Engelman, A. N. (2016) · Nature

Virus-based gene therapy researchHIV Research and Treatment

Cited by 98

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

Fontana, J., Jurado, K. A., Cheng, N., Ly, N. L., Fuchs, J. R., Gorelick, R. J., Engelman, A. N., & Steven, A. C. (2015) · Journal of Virology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 96

Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity

Shun, M.-C., Botbol, Y., Li, X., Di Nunzio, F., Daigle, J. E., Yan, N., Lieberman, J., Lavigne, M., & Engelman, A. (2008) · Journal of Virology

HIV Research and TreatmentGenomics and Chromatin Dynamics

Cited by 78

The cleavage and polyadenylation specificity factor 6 (CPSF6) subunit of the capsid-recruited pre-messenger RNA cleavage factor I (CFIm) complex mediates HIV-1 integration into genes

Rasheedi, S., Shun, M.-C., Serrao, E., Sowd, G. A., Qian, J., Hao, C., Dasgupta, T., Engelman, A. N., & Skowronski, J. (2016) · Journal of Biological Chemistry

HIV Research and TreatmentVirus-based gene therapy research

Cited by 65

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

Li, W., Singh, P. K., Sowd, G. A., Bedwell, G. J., Jang, S., Achuthan, V., Oleru, A. V., Wong, D., Fadel, H. J., Lee, K., et al. (2020) · mBio

HIV Research and TreatmentVirus-based gene therapy research

Cited by 64

Key determinants of target DNA recognition by retroviral intasomes

Serrao, E., Ballandras-Colas, A., Cherepanov, P., Maertens, G. N., & Engelman, A. N. (2015) · Retrovirology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 62

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

Elliott, J. L., Eschbach, J. E., Koneru, P. C., Li, W., Puray-Chavez, M., Townsend, D., Lawson, D. Q., Engelman, A. N., Kvaratskhelia, M., & Kutluay, S. B. (2020) · eLife

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 59

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Serrao, E., Krishnan, L., Shun, M.-C., Li, X., Cherepanov, P., Engelman, A., & Maertens, G. N. (2014) · Nucleic Acids Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 59

HIV capsid and integration targeting

Engelman, A. N. (2021) · Viruses

HIV Research and TreatmentVirus-based gene therapy research

Cited by 57

Structural basis for spumavirus GAG tethering to chromatin

Lesbats, P., Serrao, E., Maskell, D. P., Pye, V. E., O’Reilly, N., Lindemann, D., Engelman, A. N., & Cherepanov, P. (2017) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchHIV Research and Treatment

Cited by 51

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

Koneru, P. C., Francis, A. C., Deng, N., Rebensburg, S. V., Hoyte, A. C., Lindenberger, J., Adu-Ampratwum, D., Larue, R. C., Wempe, M. F., Engelman, A. N., et al. (2019) · eLife

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 49

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

Feng, L., Dharmarajan, V., Serrao, E., Hoyte, A., Larue, R. C., Slaughter, A., Sharma, A., Plumb, M. R., Kessl, J. J., Fuchs, J. R., et al. (2016) · ACS Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 37

Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors

Koh, Y., Matreyek, K. A., & Engelman, A. (2011) · Journal of Virology

HIV/AIDS drug development and treatmentVirus-based gene therapy research

Cited by 37

Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Deng, N., Hoyte, A., Mansour, Y. E., Mohamed, M. S., Fuchs, J. R., Engelman, A. N., Kvaratskhelia, M., & Levy, R. (2016) · Protein Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 36

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

Hoyte, A. C., Jamin, A. V., Koneru, P. C., Kobe, M. J., Larue, R. C., Fuchs, J. R., Engelman, A. N., & Kvaratskhelia, M. (2017) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 30

Biochemical Characterization of Novel Retroviral Integrase Proteins

Ballandras-Colas, A., Naraharisetty, H., Li, X., Serrao, E., & Engelman, A. (2013) · PLoS ONE

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 18

A Peptide Derived from Lens Epithelium–Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies

Li, M., Chen, X., Wang, H., Jurado, K. A., Engelman, A. N., & Craigie, R. (2020) · Journal of Molecular Biology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 18

Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome

Pandey, K. K., Bera, S., Shi, K., Rau, M. J., Oleru, A. V., Fitzpatrick, J. A. J., Engelman, A. N., Aihara, H., & Grandgenett, D. P. (2021) · Communications Biology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 14

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors

Singh, P., Li, W., Bedwell, G., Fadel, H., Poeschla, E., & Engelman, A. (2022) · Viruses

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 13

HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration

Li, M., Li, Z., Chen, X., Cui, Y., Engelman, A. N., & Craigie, R. (2024) · Viruses

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 12

Virus–Host Interactions in Retrovirus Integration

Engelman, A. N., & Maertens, G. N. (2018) · Retrovirus-Cell Interactions

Virus-based gene therapy researchHIV Research and Treatment

Cited by 12