Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
Open accessAbstract
The systemic administration of keratinocyte growth factor (KGF) enhances T-cell lymphopoiesis in normal mice and mice that received a bone marrow transplant. KGF exerts protection to thymic stromal cells from cytoablative conditioning and graft-versus-host disease–induced injury. However, little is known regarding KGF's molecular and cellular mechanisms of action on thymic stromal cells. Here, we report that KGF induces in vivo a transient expansion of both mature and immature thymic epithelial cells (TECs) and promotes the differentiation of the latter type of cells. The increased TEC numbers return within 2 weeks to normal values and the microenvironment displays a normal architectural organization. Stromal changes initiate an expansion of immature thymocytes and permit regular T-cell development at an increased rate and for an extended period of time. KGF signaling in TECs activates both the p53 and NF-κB pathways and results in the transcription of several target genes necessary for TEC function and T-cell development, including bone morphogenetic protein 2 (BMP2), BMP4, Wnt5b, and Wnt10b. Signaling via the canonical BMP pathway is critical for the KGF effects. Taken together, these data provide new insights into the mechanism(s) of action of exogenous KGF on TEC function and thymopoiesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FGF7 administration to old mice renews the thymic microenvironment, increases early T lineage progenitors, and restores thymus cellularity to young levels.
“FGF7 is particularly remarkable because its administration to old mice results in a renewal of the thymic microenvironment, increased numbers of ETPs, and a restoration of thymus cellularity to levels observed in the young (106, 107).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [107]
Fgf7 stimulates thymic epithelial cells to secrete various cytokines.
“Fgf7 is known to stimulate the secretion of various cytokines by thymic epithelial cells.25”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [25]
The Fgf7 receptor is expressed on thymic stromal cells but not on thymocytes.
“A third category, typified by fibroblast growth factor 7 (Fgf7; also referred to as keratinocyte growth factor), binds to receptors expressed on thymic stromal cells but not thymocytes.[23][24][25]”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967 · see citing works
Cellular signaling by fibroblast growth factor receptors
Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.001 · Cited by 1,923 · see citing works
Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921 · see citing works
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893 · see citing works
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332 · see citing works
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270 · see citing works
Self-citationAge, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy
Mackall, C. L., Fleisher, T. A., Brown, M. R., Andrich, M. P., Chen, C. C., Feuerstein, I. M., Horowitz, M. E., Magrath, I. T., Shad, A. T., Steinberg, S. M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320303 · Cited by 1,026 · see citing works
Kouhara, H., Hadari, Y., Spivak-Kroizman, T., Schilling, J., Bar-Sagi, D., Lax, I., & Schlessinger, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80252-4 · Cited by 908 · see citing works
NF-κB as a Therapeutic Target in Multiple Myeloma
Hideshima, T., Chauhan, D., Richardson, P. G. G., Mitsiades, C. S., Mitsiades, N., Hayashi, T., Munshi, N. C., Dang, L., Castro, A. C., Palombella, V. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200360200 · Cited by 894 · see citing works
Douek, D. C., Vescio, R. A., Betts, M. R., Brenchley, J. M., Hill, B. J., Zhang, L., Berenson, J. R., Collins, R. H., & Koup, R. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02293-5 · Cited by 575 · see citing works
Keratinocyte growth factor is required for hair development but not for wound healing.Preprint
Guo, L., Degenstein, L., & Fuchs, E. V. (1996) · Genes & Development · doi:10.1101/gad.10.2.165 · Cited by 534 · see citing works
Interleukin-7: from bench to clinic
Fry, T. J., & Mackall, C. L. (2002) · Blood · doi:10.1182/blood.v99.11.3892 · Cited by 502 · see citing works
Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D., & Hale, L. P. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.529 · Cited by 502 · see citing works
Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade
Sutherland, J. S., Goldberg, G. L., Hammett, M. V., Uldrich, A. P., Berzins, S. P., Heng, T. S. P., Blazar, B. R., Millar, J. L., Malin, M., Chidgey, A. P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2741 · Cited by 486 · see citing works
Self-citationCross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
Gottlieb, T. M., Martínez-Leal, J. F., Seger, R., Taya, Y., & Oren, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205181 · Cited by 473 · see citing works
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
Gray, D. H. D., Seach, N., Ueno, T., Milton, M. K., Liston, A., Lew, A. M., Goodnow, C. C., & Boyd, R. L. (2006) · Blood · doi:10.1182/blood-2006-02-004531 · Cited by 458 · see citing works
Self-citationFactors affecting thymic function after allogeneic hematopoietic stem cell transplantation
Weinberg, K. I., Blazar, B. R., Wagner, J. E., Agura, E. D., Hill, B. J., Smogorzewska, M., Koup, R. A., Betts, M. R., Collins, R. H., & Douek, D. C. (2001) · Blood · doi:10.1182/blood.v97.5.1458 · Cited by 422 · see citing works
Self-citationLind, E. F., Prockop, S. E., Porritt, H. E., & Petrie, H. T. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.127 · Cited by 402 · see citing works
Anderson, G., Jenkinson, E. J., Moore, N. C., & Owen, J. J. T. (1993) · Nature · doi:10.1038/362070a0 · Cited by 351 · see citing works
"Tolerosomes" are produced by intestinal epithelial cells
Karlsson, M., Lundin, S. B., Dahlgren, U. I., Kahu, H., Pettersson, I., & Telemo, E. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(2001010)31:10 · Cited by 303 · see citing works
The Thymus Is a Common Target Organ in Infectious Diseases
Savino, W. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020062 · Cited by 298 · see citing works
The generation and fate of thymocytes.
Shortman, K., Egerton, M., Spangrude, G. J., & Scollay, R. G. (1990) · PubMed · Cited by 295 · see citing works
Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment
Klug, D. B., Carter, C., Crouch, E., Roop, D. R., Conti, C. J., & Richie, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11822 · Cited by 286 · see citing works
Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells
Gill, J. W., Malin, M., Holländer, G. A., & Boyd, R. L. (2002) · Nature Immunology · doi:10.1038/ni812 · Cited by 286 · see citing works
Roux, E., Dumont-Girard, F., Starobinski, M., Siegrist, C., Helg, C., Chapuis, B., & Roosnek, E. E. (2000) · Blood · doi:10.1182/blood.v96.6.2299.h8002299_2299_2303 · Cited by 269 · see citing works
Identification and Characterization of Thymic Epithelial Progenitor Cells
Bennett, A. R., Farley, A., Blair, N. F., Gordon, J., Sharp, L., & Blackburn, C. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00321-7 · Cited by 267 · see citing works
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
Balc̆iūnaite, G., Keller, M. P., Balciunaite, E., Piali, L., Žuklys, S., Mathieu, Y., Gill, J. W., Boyd, R. L., Sussman, D. J., & Holländer, G. A. (2002) · Nature Immunology · doi:10.1038/ni850 · Cited by 261 · see citing works
Self-citationDevelopment of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb
Revest, J., Suniara, R. K., Kerr, K., Owen, J. J. T., & Dickson, C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1954 · Cited by 242 · see citing works
Finch, P. W., & Rubin, J. S. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91003-2 · Cited by 239 · see citing works
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration.
Alpdogan, O., Hubbard, V. M., Smith, O. M., Patel, N., Lu, S., Goldberg, G. L., Gray, D. H., Feinman, J., Kochman, A. A., Eng, J. M., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2831 · Cited by 220 · see citing works
Mackall, C. L., & GRESS, R. E. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00974.x · Cited by 217 · see citing works
Analysis of thymic stromal cell populations using flow cytometry
Gray, D. H. D., Chidgey, A. P., & Boyd, R. L. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(01)00493-8 · Cited by 205 · see citing works
Liu, C., Saito, F., Liu, Z., Lei, Y. L., Uehara, S., Love, P. E., Lipp, M., Kondo, S., Manley, N. R., & Takahama, Y. (2006) · Blood · doi:10.1182/blood-2006-05-024190 · Cited by 198 · see citing works
Self-citationRossi, S. W., Blazar, B. R., Farrell, C. L., Danilenko, D. M., Lacey, D. L., Weinberg, K. I., Krenger, W., & Holländer, G. A. (2002) · Blood · doi:10.1182/blood.v100.2.682 · Cited by 193 · see citing works
Self-citationRegulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors
Prockop, S. E., & Petrie, H. T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1604 · Cited by 190 · see citing works
BMP Signaling Is Required for Normal Thymus Development
Bleul, C. C., & Boehm, T. L. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5213 · Cited by 169 · see citing works
Porritt, H. E., Gordon, K., & Petrie, H. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030837 · Cited by 167 · see citing works
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
Scimone, M. L., Aifantis, I., Apostolou, I., von Boehmer, H., & von Andrian, U. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602024103 · Cited by 165 · see citing works
Almeida, A. R. M., Borghans, J. A. M., & Freitas, A. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.591 · Cited by 163 · see citing works
Jenkinson, W. E., Jenkinson, E. J., & Anderson, G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022135 · Cited by 160 · see citing works
Wu, C. J., Chillemi, A. C., Alyea, E. P., Orsini, E., Neuberg, D. S., Soiffer, R. J., & Ritz, J. (2000) · Blood · doi:10.1182/blood.v95.1.352 · Cited by 155 · see citing works
Regulation of thymic epithelium by keratinocyte growth factor
Erickson, M., Morkowski, S., Lehar, S. M., Gillard, G. O., Beers, C., Dooley, J., Rubin, J. S., Rudensky, A. Y., & Farr, A. G. (2002) · Blood · doi:10.1182/blood-2002-04-1036 · Cited by 154 · see citing works
Wack, A., Soldaini, E., Tseng, C.-T. K., Nuti, S., Klimpel, G. R., & Abrignani, S. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200101)31:1 · Cited by 154 · see citing works
From stem cell to T cell: one route or many?
Bhandoola, A., & Sambandam, A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1778 · Cited by 145 · see citing works
Blazar, B. R., Weisdorf, D. J., DeFor, T. E., Goldman, A. I., Braun, T., Silver, S., & Ferrara, J. L. M. (2006) · Blood · doi:10.1182/blood-2006-04-017780 · Cited by 144 · see citing works
Self-citationStrategies to enhance T-cell reconstitution in immunocompromised patients
van den Brink, M. R. M., Alpdoğan, Ö., & Boyd, R. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1484 · Cited by 141 · see citing works
The role of CCL21 in recruitment of T-precursor cells to fetal thymi
Liu, C., Ueno, T., Kuse, S., Saito, F., Nitta, T., Piali, L., Nakano, H., Kakiuchi, T., Lipp, M., Holländer, G. A., et al. (2004) · Blood · doi:10.1182/blood-2004-04-1369 · Cited by 138 · see citing works
Self-citationFukushi, N., Arase, H., Wang, B., Ogasawara, K., Gotohda, T., Good, R. A., & Onoé, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6301 · Cited by 133 · see citing works
Holländer, G. A., Widmer, B., & Burakoff, S. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1609 · Cited by 128 · see citing works
BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
Tsai, P. T., Lee, R. A., & Wu, H. (2003) · Blood · doi:10.1182/blood-2003-05-1657 · Cited by 126 · see citing works
Weerkamp, F., Baert, M. R. M., Naber, B. A. E., Koster, E. E. L., de Haas, E. F. E., Atkuri, K. R., van Dongen, J. J. M., Herzenberg, L. A., & Staal, F. J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511299103 · Cited by 119 · see citing works
The phenotypic heterogeneity of mouse thymic stromal cells.
Godfrey, D. I., Izon, D. J., Tucek, C. L., Wilson, T. J., & Boyd, R. L. (1990) · PubMed Central · Cited by 108 · see citing works
The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance
Eagar, T. N., Karandikar, N. J., Bluestone, J. A., & Miller, S. D. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200204)32:4 · Cited by 108 · see citing works
IL-7 Gene Therapy in Aging Restores Early Thymopoiesis without Reversing Involution
Phillips, J. A., Brondstetter, T. I., English, C. A., Lee, H. E., Virts, E. L., & Thoman, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4867 · Cited by 104 · see citing works
Bao, S., Wang, Y., Sweeney, P., Chaudhuri, A., Doseff, A. I., Marsh, C. B., & Knoell, D. L. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00309.2003 · Cited by 96 · see citing works
The Thymus During HIV Disease: Role in Pathogenesis and in Immune Recovery
Ye, P., Kirschner, D. E., & Kourtis, A. P. (2004) · Current HIV Research · doi:10.2174/1570162043484898 · Cited by 88 · see citing works
van den Brink, M. R. M., Moore, E., Ferrara, J. L. M., & Burakoff, S. J. (2000) · Transplantation · doi:10.1097/00007890-200002150-00026 · Cited by 82 · see citing works
Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis
Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2969-2980.2003 · Cited by 79 · see citing works
Godthelp, B. C., van Tol, M. J. D., Vossen, J. M. J. J., & van den Elsen, P. J. (1999) · Blood · doi:10.1182/blood.v94.12.4358 · Cited by 75 · see citing works
Fry, T. J., & Mackall, C. L. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704848 · Cited by 75 · see citing works
Faas, S. J., Rothstein, J. L., Kreider, B. L., Rovera, G., & Knowles, B. B. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230602 · Cited by 67 · see citing works
Krenger, W., Rossi, S. W., Piali, L., & Holländer, G. A. (2000) · Blood · doi:10.1182/blood.v96.1.347.013k26_347_354 · Cited by 66 · see citing works
Self-citationThymic epithelial antibodies: immunohistological analysis and introduction of nomenclature.
Kampinga, J., Berges, S., Boyd, R. L., Brekelmans, P., Čolić, M. J., van Ewijk, W., Kendall, Ladyman, H. M., Nieuwenhuis, P., & Ritter, M. A. (1989) · PubMed · Cited by 65 · see citing works
Portnoy, J., Curran‐Everett, D., & Mason, R. J. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0406oc · Cited by 62 · see citing works
Adkins, B., Gandour, D. M., Strober, S., & Weissman, I. L. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.10.3373 · Cited by 54 · see citing works
Desbarats, J., & Lapp, W. S. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.805 · Cited by 54 · see citing works
Heitger, A., Greinix, H. T., Mannhalter, C., Mayerl, D., Kern, H., Eder, J., Fink, F., Niederwieser, D. W., & mayer, E.-R. P.-G. (2000) · Transplantation · doi:10.1097/00007890-200006150-00026 · Cited by 53 · see citing works
Yang, S. J., Ahn, S., Park, C. S., Holmes, K. L., Westrup, J., Chang, C. H., & Kim, M. G. (2006) · International Immunology · doi:10.1093/intimm/dxl010 · Cited by 48 · see citing works
Reconstitution of thymic function after stem cell transplantation in humans
Hakim, F. T., & Gress, R. E. (2002) · Current Opinion in Hematology · doi:10.1097/00062752-200211000-00004 · Cited by 48 · see citing works
Ras inhibitors and radiation therapy
Jones, H., Hahn, S. M., Bernhard, E. J., & McKenna, W. G. (2001) · Seminars in Radiation Oncology · doi:10.1053/srao.2001.26020 · Cited by 46 · see citing works
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors
Liu, B., Podack, E. R., Allison, J. P., & Malek, T. R. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1117 · Cited by 45 · see citing works
IL-7 activates alpha4beta1 integrin in murine thymocytes
Kitazawa, H., Muegge, K., Badolato, R., Wang, J. M., Fogler, W. E., Ferris, D. K., Lee, C., Candéias, S. M., Smith, M. R., Oppenheim, J. J., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2259 · Cited by 45 · see citing works
van Vliet, E., Melis, M. L., & van Ewijk, W. (1986) · Cellular Immunology · doi:10.1016/0008-8749(86)90086-9 · Cited by 37 · see citing works
Lineage choices in the developing thymus: choosing the T and NKT pathways
Pear, W. S., Tu, L., & Stein, P. L. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.01.011 · Cited by 34 · see citing works
Wu, C. J., Chillemi, A. C., Alyea, E. P., et al. (2000) · Blood · doi:10.1182/blood.v95.1.352.001k43_352_359 · Cited by 30 · see citing works
Krenger, W., Schmidlin, H., Cavadini, G., & Holländer, G. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7359 · Cited by 24 · see citing works
Self-citationKeratinocyte growth factor (KGF) is required for post-natal thymic regeneration
Alpdoğan, Ö., Hubbard, V. M., Muriglan, S. J., Goldberg, G. L., Kochman, A. A., Eng, J. M., Smith, O. M., Boyd, R. L., & van den Brink, M. R. M. (2005) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2004.12.170 · Cited by 18 · see citing works
Central tolerance induction in natural immunoglobulin-allotype-specific T cells
Majlessi, L., Sellier, C., & Bordenave, G. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(2000012)30:12 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
- Van den Brink MR, Alpdogan O, Boyd RL. Strate- gies to enhance T-cell reconstitution in immuno- compromised patients. Nat Rev Immunol. 2004;4: 856-867.
- Jenkinson WE, Jenkinson EJ, Anderson G. Differ- ential requirement for mesenchyme in the prolif- eration and maturation of thymic epithelial pro- genitors. J Exp Med. 2003;198:325-332.
- Bleul CC, Boehm T. Chemokines define distinct microenvironments in the developing thymus. Eur J Immunol. 2000;30:3371-3379.
- Chen D, Zhao M, Mundy GR. Bone morphoge- netic proteins. Growth Factors. 2004;22:233-241.
- Powers CJ, McLeskey SW, Wellstein A. Fibro- blast growth factors, their receptors and signal- ing. Endocr Relat Cancer. 2000;7:165-197.
- Vasseur F, Le Campion A, Penit C. Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation. Eur J Immunol. 2001;31:3038-3047.
- Staal FJ, Meeldijk J, Moerer P, et al. Wnt signal- ing is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Im- munol. 2001;31:285-293.
- Mulroy T, McMahon JA, Burakoff SJ, McMahon AP, Sen J. Wnt-1 and Wnt-4 regulate thymic cel- lularity. Eur J Immunol. 2002;32:967-971.
- Almeida AR, Borghans JA, Freitas AA. T cell ho- meostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med. 2001;194:591- 599.
Cited by
Sorted by citations
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604 · see citing works
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., & Klein, L. (2008) · Nature · doi:10.1038/nature07208 · Cited by 533 · see citing works
Thymic involution and immune reconstitution.
Lynch, H. E., Goldberg, G. L., Chidgey, A., Van den Brink, M. R. M., Boyd, R., & Sempowski, G. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.003 · Cited by 522 · see citing works
The ageing immune system: is it ever too old to become young again?
Dorshkind, K. A., Montecino‐Rodriguez, E., & Signer, R. A. J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 412 · see citing works
T cell immune reconstitution following lymphodepletion
Williams, K. M., Hakim, F. T., & Gress, R. E. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.004 · Cited by 340 · see citing works
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works
An evolutionary perspective on the mechanisms of immunosenescence
Shanley, D. P., Aw, D., Manley, N. R., & Palmer, D. B. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.001 · Cited by 315 · see citing works
The Role of the Thymus in the Immune Response
Thapa, P., & Färber, D. L. (2019) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2018.12.001 · Cited by 311 · see citing works
Changes in primary lymphoid organs with aging
Chinn, I. K., Blackburn, C. C., Manley, N. R., & Sempowski, G. D. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.005 · Cited by 282 · see citing works
Rodewald, H.-R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090408 · Cited by 239 · see citing works
T cell regeneration after immunological injury
Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00457-z · Cited by 222 · see citing works
Immunosenescence: deficits in adaptive immunity in the elderly
Hakim, F. T., & Gress, R. E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00891.x · Cited by 215 · see citing works
Immune reconstitution after hematopoietic cell transplantation
Bosch, M., Khan, F. M., & Storek, J. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328353bc7d · Cited by 216 · see citing works
Generating intrathymic microenvironments to establish T-cell tolerance
Anderson, G., Lane, P. J. L., & Jenkinson, E. J. (2007) · Nature reviews. Immunology · doi:10.1038/nri2187 · Cited by 186 · see citing works
Thymus: the next (re)generation
Chaudhry, M. S., Velardi, E., Dudakov, J. A., & van den Brink, M. R. M. (2016) · Immunological Reviews · doi:10.1111/imr.12418 · Cited by 182 · see citing works
Bautista, J. L., Cramer, N. T., Miller, C. N., Chavez, J., Berrios, D. I., Byrnes, L. E., Germino, J., Ntranos, V., Sneddon, J. B., Burt, T. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21346-6 · Cited by 172 · see citing works
Immunosenescence: signaling pathways, diseases and therapeutic targets
Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 157 · see citing works
The role of sex steroids and gonadectomy in the control of thymic involution
Hince, M. N., Sakkal, S., Vlahos, K., Dudakov, J. A., Boyd, R. L., & Chidgey, A. P. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2007.10.007 · Cited by 138 · see citing works
Thymus involution and regeneration: two sides of the same coin?
Boehm, T. L. J., & Swann, J. B. (2013) · Nature reviews. Immunology · doi:10.1038/nri3534 · Cited by 136 · see citing works
Youm, Y.-H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A., & Dixit, V. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514511113 · Cited by 129 · see citing works
Improving Engraftment and Immune Reconstitution in Umbilical Cord Blood Transplantation
Danby, R., & Rocha, V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00068 · Cited by 129 · see citing works
Griffith, A. V., Fallahi, M., Venables, T., & Petrie, H. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00773.x · Cited by 120 · see citing works
Chaudhry, M. S., Velardi, E., Malard, F., & van den Brink, M. R. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601100 · Cited by 119 · see citing works
Tolerance strategies for stem-cell-based therapies
Chidgey, A. P., Layton, D., Trounson, A. O., & Boyd, R. L. (2008) · Nature · doi:10.1038/nature07041 · Cited by 118 · see citing works
Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus
Ulyanchenko, S., O’Neill, K. E., Medley, T. L., Farley, A., Vaidya, H. J., Cook, A., Blair, N. F., & Blackburn, C. C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.080 · Cited by 117 · see citing works
Chu, Y.-W., Schmitz, S., Choudhury, B., Telford, W., Kapoor, V., Garfield, S., Howe, D., & Gress, R. E. (2008) · Blood · doi:10.1182/blood-2008-04-149435 · Cited by 107 · see citing works
Impact of niche aging on thymic regeneration and immune reconstitution
Chidgey, A. P., Dudakov, J. A., Seach, N., & Boyd, R. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.006 · Cited by 105 · see citing works
Kelly, R. M., Highfill, S. L., Panoskaltsis‐Mortari, A., Taylor, P. A., Boyd, R. L., Holländer, G. A., & Blazar, B. R. (2008) · Blood · doi:10.1182/blood-2008-01-136531 · Cited by 107 · see citing works
Self-citationAge-related epithelial defects limit thymic function and regeneration
Kousa, A. I., Jahn, L., Zhao, K., Flores, A. E., Acenas, D. D., II, Lederer, E. E., Argyropoulos, K. V., Lemarquis, A. L., Granadier, D., Cooper, K., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01915-9 · Cited by 107 · see citing works
Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development
Wang, H., Pan, W., Zheng, L., Zhong, X., Tan, L., Liang, Z., He, J., Feng, P., Zhao, Y. X., & Qiu, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03099 · Cited by 100 · see citing works
Hauri-Hohl, M. M., Keller, M. P., Gill, J. W., Hafen, K., Pachlatko, E., Boulay, T., Peter, A., Holländer, G. A., & Krenger, W. (2007) · Blood · doi:10.1182/blood-2006-07-034157 · Cited by 98 · see citing works
Self-citationVentevogel, M. S., & Sempowski, G. D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.06.002 · Cited by 98 · see citing works
Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells
Depreter, M., Blair, N. F., Gaskell, T. L., Nowell, C. S., Davern, K. M., Pagliocca, A., Stenhouse, F. H., Farley, A., Fraser, A., Vrána, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711170105 · Cited by 97 · see citing works
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
Rode, I., Martins, V. C., Küblbeck, G., Maltry, N., Tessmer, C., & Rodewald, H.-R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1502010 · Cited by 90 · see citing works
Elyahu, Y., & Monsonego, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101231 · Cited by 91 · see citing works
Developmental dynamics of two bipotent thymic epithelial progenitor types
Nusser, A., Sagar, Swann, J. B., Krauth, B., Diekhoff, D., Calderón, L., Happe, C., Grün, D., & Boehm, T. L. J. (2022) · Nature · doi:10.1038/s41586-022-04752-8 · Cited by 89 · see citing works
Sun, L., Guo, J., Brown, R., Amagai, T., Zhao, Y., & Su, D. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00559.x · Cited by 83 · see citing works
Stabilized β-Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function
Žuklys, S., Gill, J. W., Keller, M. P., Hauri-Hohl, M. M., Zhanybekova, S., Balc̆iūnaite, G., Na, K.-J., Jeker, L. T., Hafen, K., Tsukamoto, N., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0713723 · Cited by 81 · see citing works
Self-citationCCL25 increases thymopoiesis after androgen withdrawal
Williams, K. M., Lucas, P. J., Bare, C. V., Wang, J., Chu, Y., Tayler, E. B., Kapoor, V., & Gress, R. E. (2008) · Blood · doi:10.1182/blood-2008-04-153627 · Cited by 81 · see citing works
The immunopathology of thymic GVHD
Krenger, W., & Holländer, G. A. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0131-6 · Cited by 78 · see citing works
Self-citationWhen the Damage Is Done: Injury and Repair in Thymus Function
Kinsella, S. M., & Dudakov, J. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01745 · Cited by 74 · see citing works
Generation of Thymic Epithelial Cell Progenitors by Mouse Embryonic Stem Cells
Lai, L., & Jin, J. (2009) · Stem Cells · doi:10.1002/stem.238 · Cited by 76 · see citing works
Zeleniak, A. E., Wiegand, C., Liu, W., McCormick, C., Ravikumar, K., Alavi, A., Guan, H., Bertera, S., Lakomy, R. A., Tajima, A., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01583-3 · Cited by 75 · see citing works
Dooley, J., Erickson, M., & Farr, A. G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5225 · Cited by 76 · see citing works
Hauri-Hohl, M. M., Žuklys, S., Keller, M. P., Jeker, L. T., Barthlott, T., Moon, A., Roes, J., & Holländer, G. A. (2008) · Blood · doi:10.1182/blood-2007-10-115618 · Cited by 72 · see citing works
Self-citationAlexandropoulos, K., & Danzl, N. (2012) · Immunologic research · doi:10.1007/s12026-012-8301-y · Cited by 1 · see citing works
Garfin, P. M., Min, D., Bryson, J. L., Serwold, T. F., Edris, B., Blackburn, C. C., Richie, E. R., Weinberg, K. I., Manley, N. R., Sage, J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121716 · Cited by 69 · see citing works
Thymus Degeneration and Regeneration
Duah, M., Li, L., Shen, J., Lan, Q., Pan, B., & Xu, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706244 · Cited by 69 · see citing works
Sitnik, K., Kotarsky, K., White, A. J., Jenkinson, W. E., Anderson, G., & Agace, W. W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200358 · Cited by 63 · see citing works
Development and developmental potential of cortical thymic epithelial cells
Ohigashi, I., Kozai, M., & Takahama, Y. (2016) · Immunological Reviews · doi:10.1111/imr.12404 · Cited by 62 · see citing works
Self-citationClinical strategies to enhance T cell reconstitution
Goldberg, G. L., Zakrzewski, J. L., Perales, M., & van den Brink, M. R. M. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.08.001 · Cited by 59 · see citing works
Sun, L., Sun, C., Liang, Z., Li, H., Chen, L., Luo, H., Zhang, H., Ding, P., Sun, X., Qin, Z., et al. (2015) · Scientific Reports · doi:10.1038/srep14871 · Cited by 58 · see citing works
Finch, P. W., Cross, L. M., McAuley, D. F., & Farrell, C. L. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12091 · Cited by 58 · see citing works
Yan, F., Mo, X., Liu, J., Ye, S., Zeng, X. Z., & Chen, D. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7525 · Cited by 58 · see citing works
Thymus aging and immune reconstitution, progresses and challenges
Li, Y. R., & Zúñiga‐Pflücker, J. C. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101837 · Cited by 57 · see citing works
Kelly, R. M., Goren, E. M., Taylor, P. A., Mueller, S. N., Stefanski, H. E., Osborn, M. J., Scott, H. S., Komarova, E. A., Gudkov, A. V., Holländer, G. A., et al. (2009) · Blood · doi:10.1182/blood-2009-05-223198 · Cited by 55 · see citing works
Self-citationNeves, H., Dupin, É., Parreira, L., & Douarin, N. M. L. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.10.022 · Cited by 55 · see citing works
Yanir, A. D., Schulz, A., Lawitschka, Á., Nierkens, S., & Eyrich, M. K. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2021.786017 · Cited by 53 · see citing works
Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines
Leposavić, G., & Nanut, M. P. (2008) · NeuroImmunoModulation · doi:10.1159/000156473 · Cited by 48 · see citing works
Dynamics of thymus function and T cell receptor repertoire breadth in health and disease
Granadier, D. W., Iovino, L., Kinsella, S. M., & Dudakov, J. A. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00840-5 · Cited by 46 · see citing works
Su, M., Hu, R., Jin, J., Yan, Y. C., Song, Y., Sullivan, R. P., & Lai, L. (2015) · Scientific Reports · doi:10.1038/srep09882 · Cited by 47 · see citing works
Berent-Maoz, B., Montecino-Rodriguez, E., Signer, R. A. J., & Dorshkind, K. (2012) · Blood · doi:10.1182/blood-2011-12-400002 · Cited by 46 · see citing works
Williams, K. M., Mella, H., Lucas, P. J., Williams, J. A., Telford, W. G., & Gress, R. E. (2009) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2009.00128.x · Cited by 46 · see citing works
Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases
Sun, L., Li, H., Luo, H., & Zhao, Y. X. (2014) · BioMed Research International · doi:10.1155/2014/206929 · Cited by 46 · see citing works
FGFR2IIIb signaling regulates thymic epithelial differentiation
Dooley, J., Erickson, M., LaRochelle, W. J., Gillard, G. O., & Farr, A. G. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21364 · Cited by 44 · see citing works
Pan, B., Wang, D., Li, L., Shang, L., Xia, F., Zhang, F., Zhang, Y., Gale, R. P., Xu, M., Li, Z., et al. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.06.002 · Cited by 44 · see citing works
Soh, C.-L., Giudice, A., Jenny, R. A., Elliott, D. A., Hatzistavrou, T., Micallef, S. J., Kianizad, K., Seach, N., Zúñiga‐Pflücker, J. C., Chidgey, A. P., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.009 · Cited by 44 · see citing works
Cavazzana, M., André‐Schmutz, I., Cortivo, L. D., Neven, B., Hacein‐Bey‐Abina, S., & Fischer, A. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.08.001 · Cited by 41 · see citing works
Getting back at nature: understanding thymic development and overcoming its atrophy
Heng, T. S. P., Chidgey, A. P., & Boyd, R. L. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.006 · Cited by 40 · see citing works
Bortolomai, I., Sandri, M., Draghici, E., Fontana, E., Campodoni, E., Marcovecchio, G. E., Ferrua, F., Perani, L., Spinelli, A. E., Canu, T., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0218 · Cited by 39 · see citing works
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
Jain, R., Sheridan, J. M., Policheni, A. N., Heinlein, M., Gandolfo, L. C., Dewson, G., Smyth, G. K., Sansom, S. N., Fu, N. Y., Visvader, J. E., et al. (2017) · Blood · doi:10.1182/blood-2017-03-771576 · Cited by 38 · see citing works
Graft-versus-host disease: a disorder of tissue regeneration and repair
Chakraverty, R. K., & Teshima, T. (2021) · Blood · doi:10.1182/blood.2021011867 · Cited by 38 · see citing works
A roadmap for thymic epithelial cell development
Anderson, G., Jenkinson, E. J., & Rodewald, H.-R. (2009) · European Journal of Immunology · doi:10.1002/eji.200939379 · Cited by 37 · see citing works
Velardi, E., Dudakov, J. A., & van den Brink, M. R. M. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.09.016 · Cited by 36 · see citing works
Human thymus regeneration and T cell reconstitution
Legrand, N., Dontje, W., van Lent, A. U., Spits, H., & Blom, B. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.001 · Cited by 35 · see citing works
Cardinale, A., Luca, C. D. D., Locatelli, F., & Velardi, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.752042 · Cited by 36 · see citing works
The thymus in GVHD pathophysiology
Krenger, W., & Holländer, G. A. (2008) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2008.02.001 · Cited by 34 · see citing works
Self-citationCord blood transplantation: evolving strategies to improve engraftment and immune reconstitution
Escalón, M. P., & Komanduri, K. V. (2010) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328335a56e · Cited by 33 · see citing works
E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex
Kadakia, T., Tai, X., Kruhlak, M. J., Wiśniewski, J., Hwang, I., Roy, S., Guinter, T. I., Alag, A., Kehrl, J. H., Zhuang, Y., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182285 · Cited by 32 · see citing works
Dertschnig, S., Nusspaumer, G., Ivánek, R., Hauri-Hohl, M. M., Holländer, G. A., & Krenger, W. (2013) · Blood · doi:10.1182/blood-2012-12-474759 · Cited by 32 · see citing works
Self-citationPrimary and secondary defects of the thymus
Dinges, S. S., Amini, K., Notarangelo, L. D., & Delmonte, O. M. (2024) · Immunological Reviews · doi:10.1111/imr.13306 · Cited by 35 · see citing works
Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution
Dudakov, J. A., Khong, D., Boyd, R. L., & Chidgey, A. P. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.02.002 · Cited by 30 · see citing works
Wang, H., Shin, J., Wang, S., Gorentla, B. K., Lin, X., Gao, J., Qiu, Y., & Zhong, X. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002370 · Cited by 30 · see citing works
Thymus Functionality Needs More Than a Few TECs
Bhalla, P., Su, D., & van Oers, N. S. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864777 · Cited by 30 · see citing works
Thymic epithelial cell development and differentiation: cellular and molecular regulation
Sun, L., Luo, H., Li, H., & Zhao, Y. X. (2013) · Protein & Cell · doi:10.1007/s13238-013-3014-0 · Cited by 29 · see citing works
Hassler, T., Urmann, E., Teschner, S., Federle, C., Dileepan, T., Schober, K., Jenkins, M. K., Busch, D. H., Hinterberger, M., & Klein, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907615116 · Cited by 29 · see citing works
Lax, S., Ross, E. A., White, A. J., Marshall, J. L., Jenkinson, W. E., Isacke, C. M., Huso, D. L., Cunningham, A. F., Anderson, G., & Buckley, C. D. (2012) · FEBS Open Bio · doi:10.1016/j.fob.2012.07.003 · Cited by 28 · see citing works
Emre, Y., Irla, M., Dunand-Sauthier, I., Ballet, R., Meguenani, M., Jemelin, S., Vesin, C., Reith, W., & Imhof, B. A. (2013) · Nature Communications · doi:10.1038/ncomms3842 · Cited by 27 · see citing works
Danzl, N., Donlin, L. T., & Alexandropoulos, K. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092384 · Cited by 27 · see citing works
Thymic epithelial organoids mediate T-cell development
Hübscher, T., Lorenzo‐Martín, L. F., Barthlott, T., Tillard, L., Langer, J., Rouse, P., Blackburn, C. C., Holländer, G. A., & Lütolf, M. P. (2024) · Development · doi:10.1242/dev.202853 · Cited by 26 · see citing works
Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile
Patenaude, J., & Perreault, C. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502499 · Cited by 26 · see citing works
Sultana, D. A., Tomita, S., Hamada, M., Iwanaga, Y., Kitahama, Y., Khang, N. V., Hirai, S., Ohigashi, I., Nitta, S., Amagai, T., et al. (2009) · Blood · doi:10.1182/blood-2008-06-164921 · Cited by 26 · see citing works
Self-citationKey players for T-cell regeneration
Awong, G., Motte-Mohs, R. N. L., & Zúñiga‐Pflücker, J. C. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283395133 · Cited by 25 · see citing works
Jenq, R. R., King, C. G., Volk, C., Suh, D. Y., Smith, O. M., Rao, U. K., Yim, N. L., Holland, A. M., Lu, S. X., Zakrzewski, J. L., et al. (2008) · Blood · doi:10.1182/blood-2008-05-155697 · Cited by 25 · see citing works
Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases
Upadhyay, P., Suhail, A., Khanal, P., & Kumar, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637191 · Cited by 24 · see citing works
Liu, G., Wang, L., Pang, T., Zhu, D., Xu, Y., Wang, H., Cong, X., & Liu, Y.-J. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.69 · Cited by 24 · see citing works
Genetic regulation of thymocyte progenitor aging
Berent-Maoz, B., Montecino‐Rodriguez, E., & Dorshkind, K. A. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.006 · Cited by 24 · see citing works
Bruinsma, M., van Soest, P. L., Leenen, P. J. M., Lambrecht, B. N., Cupedo, T., Löwenberg, B., Cornelissen, J. J., & Braakman, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7424 · Cited by 22 · see citing works
Simons, L., Cavazzana, M., & André‐Schmutz, I. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0248 · Cited by 21 · see citing works
- Authors
- Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., & Holländer, G. A.
- Affiliations
- University of Basel (CH)
- Tokushima University (JP)
- Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland;
- Cleveland Clinic (US)
- University of Minnesota (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-01-09
- Volume
- 109
- Issue
- 9
- Pages
- 3803-3811
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1874572
- OpenAlex
- W2012330112
- Cited by
- 215
- References
- 78
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 1 · 2017: 7 · 2016: 14 · 2015: 6 · 2014: 8 · 2013: 15 · 2012: 13
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Dana Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (68310, 3100-68310.02)
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL073794)
- National Institute of Allergy and Infectious Diseases (R01 AI 1057477)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- keratinocyte growth factor, thymic epithelial cells, T cell development, thymopoiesis, thymic stromal cells, bone marrow transplantation, graft-versus-host disease, p53 pathway, NF-κB signaling, BMP signaling, Wnt signaling, thymocyte proliferation
- MeSH terms
- Animals, Cell Differentiation, Epithelial Cells, Female, T-Lymphocytes, Thymus Gland, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Bone Morphogenetic Proteins, Lymphopoiesis, Cell Proliferation, Mice, Fibroblast Growth Factor 7
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
