Schulman, Howard

The molecular basis of CaMKII function in synaptic and behavioural memory

Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 1,860

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

Malinow, R., Schulman, H., & Tsien, R. W. (1989) · Science

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 1,325

Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations

De Koninck, P., & Schulman, H. (1998) · Science

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 1,269

Interaction with the NMDA receptor locks CaMKII in an active conformation

Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., & Schulman, H. (2001) · Nature

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 732

Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase

Meyer, T., Hanson, P. I., Stryer, L., & Schulman, H. (1992) · Science

Protein Kinase Regulation and GTPase SignalingS100 Proteins and Annexins

Cited by 637

Structure–function of the multifunctional Ca2+/calmodulin-dependent protein kinase II

HUDMON, A., & SCHULMAN, H. (2002) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 615

Dual role of calmodulin in autophosphorylation of multifunctional cam kinase may underlie decoding of calcium signals

Hanson, P. I., Meyer, T., Stryer, L., & Schulman, H. (1994) · Neuron

Protein Kinase Regulation and GTPase SignalingIon channel regulation and function

Cited by 500

Global changes to the ubiquitin system in Huntington's disease

Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K.-Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Schulman, H., & Kopito, R. R. (2007) · Nature

Genetic Neurodegenerative DiseasesUbiquitin and proteasome pathways

Cited by 497

Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII

Fink, C. C., Bayer, K.-U., Myers, J. W., Ferrell, J. E., Schulman, H., & Meyer, T. (2003) · Neuron

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 328

Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis.

Hanson, P. I., & Schulman, H. (1992) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 216

Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme.

Lou, L. L., Lloyd, S. J., & Schulman, H. (1986) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 206

A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins

Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R. (2007) · Molecular Psychiatry

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 197

An ultrasensitive Ca 2+ /calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling

Bradshaw, J. M., Kubota, Y., Meyer, T., & Schulman, H. (2003) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 189

Substrate-directed Function of Calmodulin in Autophosphorylation of Ca2+/Calmodulin-dependent Protein Kinase II

Rich, R. C., & Schulman, H. (1998) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 162

Functional Implications of the Subunit Composition of Neuronal CaM Kinase II

Brocke, L., Chiang, L. W., Wagner, P. D., & Schulman, H. (1999) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 161

Distinct autophosphorylation sites sequentially produce autonomy and inhibition of the multifunctional Ca2+/calmodulin-dependent protein kinase

Lou, L., & Schulman, H. (1989) · The Journal of Neuroscience

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 161

A Mechanism for Ca 2+ /Calmodulin-Dependent Protein Kinase II Clustering at Synaptic and Nonsynaptic Sites Based on Self-Association

Hudmon, A., LeBel, E., Roy, H., Sik, A., Schulman, H., Waxham, M. N., & De Koninck, P. (2005) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 159

Structural Examination of Autoregulation of Multifunctional Calcium/Calmodulin-dependent Protein Kinase II

Yang, E., & Schulman, H. (1999) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 152

Cross-talk between protein kinase C and multifunctional Ca2+/calmodulin-dependent protein kinase.

MacNicol, M., & Schulman, H. (1992) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 131

Synaptic memory and CaMKII

Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 126

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

Chao, L. H., Pellicena, P., Deindl, S., Barclay, L. A., Schulman, H., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 119

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

Stratton, M., Lee, I.-H., Bhattacharyya, M., Christensen, S. M., Chao, L. H., Schulman, H., Groves, J. T., & Kuriyan, J. (2014) · eLife

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 114

Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

Bhattacharyya, M., Stratton, M. M., Going, C. C., McSpadden, E. D., Huang, Y., Susa, A. C., Elleman, A., Cao, Y. M., Pappireddi, N., Burkhardt, P., et al. (2016) · eLife

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 112

Alternative splicing modulates the frequency‐dependent response of CaMKII to Ca2+ oscillations

Bayer, K. U., Koninck, P. D., & Schulman, H. (2002) · The EMBO Journal

Protein Kinase Regulation and GTPase SignalingRNA Research and Splicing

Cited by 112