Matano, Mami

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T., & Sato, T. (2015) · Nature Medicine

Cancer Cells and MetastasisCRISPR and Genetic Engineering

Cited by 1,135

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., et al. (2016) · Cell Stem Cell

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 852

Visualization and targeting of LGR5+ human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T., & Sato, T. (2017) · Nature

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 728

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., et al. (2018) · Cell Stem Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 631

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S., & Sato, T. (2018) · Cell Stem Cell

Cancer Cells and MetastasisPluripotent Stem Cells Research

Cited by 558

Efficient genetic engineering of human intestinal organoids using electroporation

Fujii, M., Matano, M., Nanki, K., & Sato, T. (2015) · Nature Protocols

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 364

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

Kawasaki, K., Toshimitsu, K., Matano, M., Fujita, M., Fujii, M., Togasaki, K., Ebisudani, T., Shimokawa, M., Takano, A., Takahashi, S., et al. (2020) · Cell

Neuroendocrine Tumor Research AdvancesGenetic factors in colorectal cancer

Cited by 238

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., et al. (2018) · Cell Stem Cell

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 196

An organoid-based organ-repurposing approach to treat short bowel syndrome

Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., et al. (2021) · Nature

Tissue Engineering and Regenerative MedicineClinical Nutrition and Gastroenterology

Cited by 175

Generation of human adult hepatocyte organoids with metabolic functions

Igarashi, R., Oda, M., Okada, R., Yano, T., Takahashi, S., Pastuhov, S., Matano, M., Masuda, N., Togasaki, K., Ohta, Y., et al. (2025) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 85