Baeuerle, Patrick A.

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 4,745

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

Schreck, R., Meier, B., Männel, D. N., Dröge, W., & Baeuerle, P. A. (1992) · The Journal of experimental medicine

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 1,508

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

Bargou, R., Leo, E., Zugmaier, G., Klinger, M., Goebeler, M., Knop, S., Noppeney, R., Viardot, A., Hess, G., Schuler, M., et al. (2008) · Science

Monoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy research

Cited by 1,078

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine

NF-κB Signaling PathwaysRedox biology and oxidative stress

Cited by 666

Bispecific T-Cell Engaging Antibodies for Cancer Therapy

Baeuerle, P. A., & Reinhardt, C. (2009) · Cancer Research

Monoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy research

Cited by 592

The Emerging Role of EpCAM in Cancer and Stem Cell Signaling

Munz, M., Baeuerle, P. A., & Gires, O. (2009) · Cancer Research

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 515

Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells

Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P., & Baeuerle, P. A. (2006) · Molecular Immunology

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 365

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Hoffmann, P., Hofmeister, R., Brischwein, K., Brandl, C., Crommer, S., Bargou, R., Itin, C., Prang, N., & Baeuerle, P. A. (2005) · International Journal of Cancer

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 344

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition

Zabel, U., Schreck, R., & Baeuerle, P. A. (1991) · Journal of Biological Chemistry

NF-κB Signaling PathwaysGenomics and Chromatin Dynamics

Cited by 344

BiTEs: bispecific antibody constructs with unique anti-tumor activity

Wolf, E., Hofmeister, R., Kufer, P., Schlereth, B., & Baeuerle, P. A. (2005) · Drug Discovery Today

Monoclonal and Polyclonal Antibodies ResearchToxin Mechanisms and Immunotoxins

Cited by 260

MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

Brischwein, K., Schlereth, B., Guller, B., Steiger, C., Wolf, A., Lutterbuese, R., Offner, S., Locher, M., Urbig, T., Raum, T., et al. (2006) · Molecular Immunology

Monoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune Responses

Cited by 256

T Cell Costimulus-Independent and Very Efficacious Inhibition of Tumor Growth in Mice Bearing Subcutaneous or Leukemic Human B Cell Lymphoma Xenografts by a CD19-/CD3- Bispecific Single-Chain Antibody Construct

Dreier, T., Baeuerle, P. A., Fichtner, I., Grün, M., Schlereth, B., Lorenczewski, G., Kufer, P., Lutterbüse, R., Riethmüller, G., Gjorstrup, P., et al. (2003) · The Journal of Immunology

Monoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy research

Cited by 191

Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid

Camandola, S., Leonarduzzi, G., Musso, T., Varesio, L., Carini, R., Scavazza, A., Chiarpotto, E., Baeuerle, P. A., & Poli, G. (1996) · Biochemical and Biophysical Research Communications

Fatty Acid Research and HealthInflammatory mediators and NSAID effects

Cited by 188

Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class

Brischwein, K., Parr, L., Pflanz, S., Volkland, J., Lumsden, J., Klinger, M., Locher, M., Hammond, S. A., Kiener, P., Kufer, P., et al. (2007) · Journal of Immunotherapy

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 187

T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

Lutterbuese, R., Raum, T., Kischel, R., Hoffmann, P., Mangold, S., Rattel, B., Friedrich, M., Thomas, O., Lorenczewski, G., Rau, D., et al. (2010) · Proceedings of the National Academy of Sciences

Monoclonal and Polyclonal Antibodies ResearchColorectal Cancer Treatments and Studies

Cited by 166

A revival of bispecific antibodies

Kufer, P., Lutterbüse, R., & Baeuerle, P. A. (2004) · Trends in Biotechnology

Monoclonal and Polyclonal Antibodies ResearchToxin Mechanisms and Immunotoxins

Cited by 157

Eradication of Tumors from a Human Colon Cancer Cell Line and from Ovarian Cancer Metastases in Immunodeficient Mice by a Single-Chain Ep-CAM-/CD3-Bispecific Antibody Construct

Schlereth, B., Fichtner, I., Lorenczewski, G., Kleindienst, P., Brischwein, K., da Silva, A., Kufer, P., Lutterbuese, R., Junghahn, I., Kasimir-Bauer, S., et al. (2005) · Cancer Research

Monoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune Responses

Cited by 132

T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

Schlereth, B., Quadt, C., Dreier, T., Kufer, P., Lorenczewski, G., Prang, N., Brandl, C., Lippold, S., Cobb, K., Brasky, K., et al. (2006) · Cancer Immunology, Immunotherapy

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 103

Therapeutic Window of MuS110, a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD3

Amann, M., Brischwein, K., Lutterbuese, P., Parr, L., Petersen, L., Lorenczewski, G., Krinner, E., Bruckmeier, S., Lippold, S., Kischel, R., et al. (2008) · Cancer Research

Monoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune Responses

Cited by 90

Highly Efficient Elimination of Colorectal Tumor-Initiating Cells by an EpCAM/CD3-Bispecific Antibody Engaging Human T Cells

Herrmann, I., Baeuerle, P. A., Friedrich, M., Murr, A., Filusch, S., Rüttinger, D., Majdoub, M. W., Sharma, S., Kufer, P., Raum, T., et al. (2010) · PLoS ONE

Cancer Cells and MetastasisImmunotherapy and Immune Responses

Cited by 85

Potent Control of Tumor Growth by CEA/CD3-bispecific Single-chain Antibody Constructs That Are Not Competitively Inhibited by Soluble CEA

Lutterbuese, R., Raum, T., Kischel, R., Lutterbuese, P., Schlereth, B., Schaller, E., Mangold, S., Rau, D., Meier, P., Kiener, P. A., et al. (2009) · Journal of Immunotherapy

Monoclonal and Polyclonal Antibodies ResearchToxin Mechanisms and Immunotoxins

Cited by 77