The Emerging Role of EpCAM in Cancer and Stem Cell Signaling
Open accessAbstract
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway. [Cancer Res 2009;69(14):5627–9]
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EpCAM is very often on cancer stem cells, a very attractive feature for a tumor marker.
“Moreover, EpCAM is very often on cancer stem cells, a very attractive feature for a tumor marker. 24”
From Bispecific antibodies for cancer therapy: The light at the end of the tunnel? (2009) · cites this paper as [24]
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- Authors
- Munz, M., Baeuerle, P. A., & Gires, O.
- Affiliations
- 1Micromet AG, Munich, Germany;
- Helmholtz Munich (DE)
- Venue
- Cancer Research
- Published
- 2009-07-15
- Volume
- 69
- Issue
- 14
- Pages
- 5627-5629
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2158741313
- Cited by
- 515
- References
- 20
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 17 · 2023: 27 · 2022: 18 · 2021: 21 · 2020: 39 · 2019: 36 · 2018: 38 · 2017: 32 · 2016: 35 · 2015: 40 · 2014: 38 · 2013: 41 · 2012: 29
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Krebshilfe
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- EpCAM, cancer stem cells, oncogenic signaling, Wnt signaling, cytoplasmic domain, prognostic factors, therapeutic antibodies, colon cancer, nuclear translocation
- MeSH terms
- Epithelial Cell Adhesion Molecule, Animals, Antigens, Neoplasm, Humans, Models, Biological, Neoplasms, Protein Binding, Stem Cells, Signal Transduction, Cell Adhesion Molecules, beta Catenin
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