Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025 · see citing works

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305 · see citing works

Tumor Antigens Recognized by T Lymphocytes

Boon, T., Cerottini, J. C., den Eynde, B. J. V., van der Bruggen, P., & Pel, A. V. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.002005 · Cited by 1,228 · see citing works

The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

Stinchcombe, J. C., Bossi, G., Booth, S., & Griffiths, G. M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00234-5 · Cited by 817 · see citing works

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

Gorelik, L., & Flavell, R. A. (2001) · Nature Medicine · doi:10.1038/nm1001-1118 · Cited by 770 · see citing works

T Cell Receptor Signaling Precedes Immunological Synapse Formation

Lee, K., Holdorf, A. D., Dustin, M. L., Chan, A. C., Allen, P. M., & Shaw, A. S. (2002) · Science · doi:10.1126/science.1067710 · Cited by 684 · see citing works

The biology of the 17–1A antigen (Ep-CAM)

Balzar, M., Winter, M. J., de Boer, C. J., & Litvinov, S. V. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900038 · Cited by 545 · see citing works

Erratum: Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomão, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm0902-1039c · Cited by 545 · see citing works

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Lee, K., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, R., Wu, H., Wang, J., et al. (2003) · Science · doi:10.1126/science.1086507 · Cited by 541 · see citing works

A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes

Löffler, A., Kufer, P., Lutterbüse, R., Zettl, F., Daniel, P. T., Schwenkenbecher, J. M., Riethmüller, G., Dörken, B., & Bargou, R. C. (2000) · Blood · doi:10.1182/blood.v95.6.2098 · Cited by 445 · see citing works

Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones

Shaw, S., Luce, G. E. G., Quinones, R., et al. (1986) · Nature · doi:10.1038/323262a0 · Cited by 429 · see citing works

A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.

Mack, M., Riethmüller, G., & Kufer, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7021 · Cited by 351 · see citing works

Extremely potent, rapid and costimulation‐independent cytotoxic T‐cell response against lymphoma cells catalyzed by a single‐chain bispecific antibody

Dreier, T., Lorenczewski, G., Brandl, C., Hoffmann, P., Syring, U., Hanakam, F., Kufer, P., Riethmüller, G., Bargou, R. C., & Baeuerle, P. A. (2002) · International Journal of Cancer · doi:10.1002/ijc.10557 · Cited by 348 · see citing works

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

van der Merwe, P. A., Davis, S. J., Shaw, A. S., & Dustin, M. L. (2000) · Seminars in Immunology · doi:10.1006/smim.2000.0203 · Cited by 290 · see citing works

Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold

Faroudi, M., Utzny, C., Salio, M., Cerundolo, V., Guiraud, M., Müller, S., & Valitutti, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334336100 · Cited by 240 · see citing works

Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer

Knabel, M., Franz, T. J., Schiemann, M., Wulf, A., Villmow, B., Schmidt, B., Bernhard, H., Wagner, H., & Busch, D. H. (2002) · Nature Medicine · doi:10.1038/nm0602-631 · Cited by 211 · see citing works

Human Leukocyte Antigen G Up-Regulation in Lung Cancer Associates with High-Grade Histology, Human Leukocyte Antigen Class I Loss and Interleukin-10 Production

Urosevic, M., Kurrer, M. O., Kamarashev, J. A., Mueller, B., Weder, W., Burg, G., Stahel, R. A., Dummer, R., & Trojan, A. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61756-7 · Cited by 201 · see citing works

Natural T cell immunity against cancer.

Nagorsen, D., Scheibenbogen, C., Marincola, F. M., Letsch, A., & Keilholz, U. (2003) · PubMed · Cited by 197 · see citing works

T Cell Costimulus-Independent and Very Efficacious Inhibition of Tumor Growth in Mice Bearing Subcutaneous or Leukemic Human B Cell Lymphoma Xenografts by a CD19-/CD3- Bispecific Single-Chain Antibody Construct

Dreier, T., Baeuerle, P. A., Fichtner, I., Grün, M., Schlereth, B., Lorenczewski, G., Kufer, P., Lutterbüse, R., Riethmüller, G., Gjorstrup, P., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4397 · Cited by 191 · see citing works

The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.

Kupfer, A., Swain, S. L., & Singer, S. J. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.6.1565 · Cited by 182 · see citing works

EpCAM: A New Therapeutic Target for an Old Cancer Antigen

Armstrong, A., & Eck, S. L. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.4.451 · Cited by 166 · see citing works

Bispecific antibodies in cancer therapy

Segal, D. M., Weiner, G. J., & Weiner, L. M. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00015-1 · Cited by 161 · see citing works

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

Bladergroen, B. A., Meijer, C. J. L. M., ten Berge, R. L., Hack, C. E., Muris, J. J. F., Dukers, D. F., Chott, A., Kazama, Y., Oudejans, J. J., van Berkum, O., et al. (2002) · Blood · doi:10.1182/blood.v99.1.232 · Cited by 154 · see citing works

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

Leupin, O., Zaru, R., Laroche, T., Müller, S., & Valitutti, S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00362-6 · Cited by 151 · see citing works

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

Löffler, A., Gruen, M., Wuchter, C., Schriever, F., Kufer, P., Dreier, T., Hanakam, F., Baeuerle, P. A., Bommert, K., Karawajew, L., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2402890 · Cited by 150 · see citing works

Vav Family Proteins Couple to Diverse Cell Surface Receptors

Moores, S. L., Selfors, L. M., Fredericks, J., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6364-6373.2000 · Cited by 147 · see citing works

Alloantigen Recognition Is Preceded by Nonspecific Adhesion of Cytotoxic T Cells and Target Cells

Spits, H., van Schooten, W., Keizer, H. G., et al. (1986) · Science · doi:10.1126/science.3485822 · Cited by 143 · see citing works

Tumour MHC class I downregulation and immunotherapy (Review)

Bubenik, J. (2003) · Oncology Reports · doi:10.3892/or.10.6.2005 · Cited by 133 · see citing works

Cytotoxic T lymphocytes form an antigen-independent ring junction

Somersalo, K., Anikeeva, N., Sims, T. N., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19337 · Cited by 123 · see citing works

Linking the T Cell Surface Protein CD2 to the Actin-capping Protein CAPZ via CMS and CIN85

Hutchings, N. J., Clarkson, N. G., Chalkley, R. J., Barclay, A. N., & Brown, M. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302540200 · Cited by 123 · see citing works

Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity

Mack, M., Gruber, R., Schmidt, S., Riethmüller, G., & Kufer, P. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.8.3965 · Cited by 86 · see citing works

Loss of B7.2 (CD86) and intracellular adhesion molecule 1 (CD54) expression is associated with decreased tumor-infiltrating T lymphocytes in diffuse B-cell large-cell lymphoma.

Stopeck, A., Gessner, A., Miller, T. P., et al. (2000) · PubMed · Cited by 70 · see citing works

Formation of a central supramolecular activation cluster is not required for activation of naive CD8 + T cells

O’Keefe, J. P., Blaine, K. M., Alegre, M., & Gajewski, T. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305965101 · Cited by 67 · see citing works

Biology of FasL

Lee, H., & Ferguson, T. A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00028-5 · Cited by 65 · see citing works

Bispecific antibodies for polyclonal T-cell engagement.

Baeuerle, P. A., Kufer, P., & Lutterbüse, R. (2003) · PubMed · Cited by 50 · see citing works

Coordination of T Cell Activation and Migration through Formation of the Immunological Synapse

Dustin, M. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb06032.x · Cited by 45 · see citing works

CD5 (OKT1) Augments CD3-Mediated Intracellular Signaling Events in Human T Lymphocytes

Berney, S. M., Schaan, T., Wolf, R. E., et al. (2001) · Inflammation · doi:10.1023/a:1010919719200 · Cited by 11 · see citing works

The regulation of exogenous and endogenous class I MHC genes in a human tumor cell line, K562

Maziarz, R. T., Burakoff, S. J., & Faller, D. V. (1990) · Molecular Immunology · doi:10.1016/0161-5890(90)90108-c · Cited by 9 · see citing works

CD2 (OKT11) Augments CD3-Mediated Intracellular Signaling Events in Human T Lymphocytes

Berney, S. M., Schaan, T., Wolf, R., et al. (2000) · Journal of Investigative Medicine · doi:10.1177/108155890004800205 · Cited by 7 · see citing works

Bispecific antibodies: a mechanistic review of the pipeline

Labrijn, A. F., Janmaat, M. L., Reichert, J. M., & Parren, P. W. H. I. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0028-1 · Cited by 1,303 · see citing works

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

Bargou, R., Leo, E., Zugmaier, G., Klinger, M., Goebeler, M., Knop, S., Noppeney, R., Viardot, A., Hess, G., Schuler, M., et al. (2008) · Science · doi:10.1126/science.1158545 · Cited by 1,078 · see citing works

Bispecific antibodies for cancer therapy: The light at the end of the tunnel?

Chames, P., & Baty, D. (2009) · mAbs · doi:10.4161/mabs.1.6.10015 · Cited by 336 · see citing works

BiTEs: bispecific antibody constructs with unique anti-tumor activity

Wolf, E., Hofmeister, R., Kufer, P., Schlereth, B., & Baeuerle, P. A. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03554-3 · Cited by 260 · see citing works

MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

Brischwein, K., Schlereth, B., Guller, B., Steiger, C., Wolf, A., Lutterbuese, R., Offner, S., Locher, M., Urbig, T., Raum, T., et al. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.07.034 · Cited by 256 · see citing works

Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class

Brischwein, K., Parr, L., Pflanz, S., Volkland, J., Lumsden, J., Klinger, M., Locher, M., Hammond, S. A., Kiener, P., Kufer, P., et al. (2007) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318156750c · Cited by 187 · see citing works

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Engelberts, P. J., Hiemstra, I. H., de Jong, B., Schuurhuis, D. H., Meesters, J., Beltran Hernandez, I., Oostindie, S. C., Neijssen, J., van den Brink, E. N., Horbach, G. J., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2019.102625 · Cited by 172 · see citing works

Therapeutic Window of MuS110, a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD3

Amann, M., Brischwein, K., Lutterbuese, P., Parr, L., Petersen, L., Lorenczewski, G., Krinner, E., Bruckmeier, S., Lippold, S., Kischel, R., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2182 · Cited by 90 · see citing works

Highly Efficient Elimination of Colorectal Tumor-Initiating Cells by an EpCAM/CD3-Bispecific Antibody Engaging Human T Cells

Herrmann, I., Baeuerle, P. A., Friedrich, M., Murr, A., Filusch, S., Rüttinger, D., Majdoub, M. W., Sharma, S., Kufer, P., Raum, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013474 · Cited by 85 · see citing works

Clinical Pharmacology and Translational Aspects of Bispecific Antibodies

Trivedi, A., Stienen, S., Zhu, M., Li, H., Yuraszeck, T., Gibbs, J., Heath, T., Loberg, R., & Kasichayanula, S. (2017) · Clinical and Translational Science · doi:10.1111/cts.12459 · Cited by 76 · see citing works

H pylorireceptor MHC class II contributes to the dynamic gastric epithelial apoptotic response

Bland, D. A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i33.5306 · Cited by 7 · see citing works

Supplementary Figure 1.Optimization IHC on pilot series of cHL cases. from Classical Hodgkin Lymphoma with Reduced β2M/MHC Class I Expression Is Associated with Inferior Outcome Independent of 9p24.1 Status

Roemer, M. G. M., Advani, R. H., Redd, R. A., et al. (2023) · doi:10.1158/2326-6066.22538642

Supplementary Figure 1.Optimization IHC on pilot series of cHL cases. from Classical Hodgkin Lymphoma with Reduced β2M/MHC Class I Expression Is Associated with Inferior Outcome Independent of 9p24.1 Status

Roemer, M. G. M., Advani, R. H., Redd, R. A., et al. (2023) · doi:10.1158/2326-6066.22538642.v1

CpG DNA Induces a Class II Transactivator-Independent Increase in Class II MHC by Stabilizing Class II MHC mRNA in B Lymphocytes

Kuchtey, J., Pennini, M. E., Pai, R. K., & Harding, C. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2320 · Cited by 19 · see citing works

Melanosomal Targeting Sequences from gp100 Are Essential for MHC Class II–Restricted Endogenous Epitope Presentation and Mobilization to Endosomal Compartments

Lepage, S. E., & Lapointe, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2516 · Cited by 31 · see citing works