Motohashi, Hozumi

The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,968

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Hayashi, M., Sekine, H., Tanaka, N., Moriguchi, T., Motohashi, H., Nakayama, K., et al. (2016) · Nature Communications

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 1,878

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,725

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

Taguchi, K., Motohashi, H., & Yamamoto, M. (2011) · Genes to Cells

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,478

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 1,395

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Ida, T., Sawa, T., Ihara, H., Tsuchiya, Y., Watanabe, Y., Kumagai, Y., Suematsu, M., Motohashi, H., Fujii, S., Matsunaga, T., et al. (2014) · Proceedings of the National Academy of Sciences

Sulfur Compounds in BiologyRedox biology and oxidative stress

Cited by 934

Toward clinical application of the Keap1-Nrf2 pathway

Suzuki, T., Motohashi, H., & Yamamoto, M. (2013) · Trends in Pharmacological Sciences

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 680

Keap1 degradation by autophagy for the maintenance of redox homeostasis

Taguchi, K., Fujikawa, N., Komatsu, M., Ishii, T., Unno, M., Akaike, T., Motohashi, H., & Yamamoto, M. (2012) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressAutophagy in Disease and Therapy

Cited by 482

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., et al. (2017) · Scientific Data

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 310

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H.-C., Ikeda, K., Kanegae, Y., et al. (2019) · Nature Communications

Autophagy in Disease and TherapyPeroxisome Proliferator-Activated Receptors

Cited by 193

Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.

Tauchi, M., Hida, A., Negishi, T., Katsuoka, F., Noda, S., Mimura, J., Hosoya, T., Yanaka, A., Aburatani, H., Fujii-Kuriyama, Y., et al. (2005) · Molecular and Cellular Biology

Dermatology and Skin DiseasesToxic Organic Pollutants Impact

Cited by 167

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

Moriguchi, T., Motohashi, H., Hosoya, T., Nakajima, O., Takahashi, S., Ohsako, S., Aoki, Y., Nishimura, N., Tohyama, C., Fujii-Kuriyama, Y., et al. (2003) · Proceedings of the National Academy of Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 164

NRF2 immunolocalization in human breast cancer patients as a prognostic factor

Onodera, Y., Motohashi, H., Takagi, K., Miki, Y., Shibahara, Y., Watanabe, M., Ishida, T., Hirakawa, H., Sasano, H., Yamamoto, M., et al. (2014) · Endocrine-Related Cancer

Genomics, phytochemicals, and oxidative stressBreast Cancer Treatment Studies

Cited by 81

Metabolic features of cancer cells in NRF2 addiction status

Okazaki, K., Papagiannakopoulos, T., & Motohashi, H. (2020) · Biophysical Reviews

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 57

Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

Cuadrado, A., Cazalla, E., Bach, A., Bathish, B., Naidu, S. D., DeNicola, G. M., Dinkova-Kostova, A. T., Fernández-Ginés, R., Grochot-Przeczek, A., Hayes, J. D., et al. (2025) · Redox Biology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 28