Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

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Targeting the KEAP1-NRF2 system to prevent kidney disease progression

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A multisociety Delphi consensus statement on new fatty liver disease nomenclature

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Reactive oxygen species have a causal role in multiple forms of insulin resistance

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

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The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

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The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

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Molecular mediators of hepatic steatosis and liver injury

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Ulcerative colitis

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Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.

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NRF2 and the Hallmarks of Cancer

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

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Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

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p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

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The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

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Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

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Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis.

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

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Crohn’s disease

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Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

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NAFLD, NASH and liver cancer

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Commensal bacteria at the interface of host metabolism and the immune system

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

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A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

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Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

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ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

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Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[ a ]pyrene-induced stomach tumors

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Expression of Nrf2 in Neurodegenerative Diseases

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Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

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NRF2 regulates serine biosynthesis in non–small cell lung cancer

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Metformin: update on mechanisms of action and repurposing potential

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Cancer related mutations in <i>NRF2</i> impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

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Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

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Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

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Oxidative Stress in Cardiovascular Diseases

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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

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Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

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p62 links autophagy and Nrf2 signaling

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Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

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Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

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Molecular pathways of nonalcoholic fatty liver disease development and progression

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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

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Protein neddylation: beyond cullin–RING ligases

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Structure of a β-TrCP1-Skp1-β-Catenin Complex

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

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Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice

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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

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Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

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Nrf2 is essential for protection against acute pulmonary injury in mice

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Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

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Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

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Proteogenomic data and resources for pan-cancer analysis

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Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance

Yu, H. A., Suzawa, K., Jordan, E., Zehir, A., Ni, A., Kim, R., Kris, M. G., Hellmann, M. D., Li, B. T., Somwar, R., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2961 · Cited by 259 · see citing works

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

Ashabi, G., Khalaj, L., Khodagholi, F., Goudarzvand, M., & Sarkaki, A. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9632-2 · Cited by 256 · see citing works

The Crosstalk between Nrf2 and Inflammasomes

Hennig, P., Garstkiewicz, M., Grossi, S., Filippo, M. D., French, L. E., & Beer, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020562 · Cited by 256 · see citing works

Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress

Li, J., Ichikawa, T., Villacorta, L., Janicki, J. S., Brower, G. L., Yamamoto, M. P., & Cui, T. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.189480 · Cited by 254 · see citing works

Small Maf proteins (MafF, MafG, MafK): History, structure and function

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Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

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Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

Cheung, E. C., DeNicola, G. M., Nixon, C., Blyth, K., Labuschagne, C. F., Tuveson, D. A., & Vousden, K. H. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.012 · Cited by 247 · see citing works

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

Wohlhieter, C. A., Richards, A. L., Uddin, F. Z., Hulton, C. H., Quintanal-Villalonga, À., Martin, A. S., de Stanchina, E., Bhanot, U. K., Asher, M., Shah, N., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108444 · Cited by 247 · see citing works

Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice

Lewis, P., Stefanovic, N., Pete, J., Calkin, A. C., Giunti, S., Thallas‐Bonke, V., Jandeleit-Dahm, K. A. M., Allen, T. J., Kola, I., Cooper, M. E., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.664250 · Cited by 246 · see citing works

Multiorgan Autoimmune Inflammation, Enhanced Lymphoproliferation, and Impaired Homeostasis of Reactive Oxygen Species in Mice Lacking the Antioxidant-Activated Transcription Factor Nrf2

Ma, Q., Battelli, L. A., & Hubbs, A. F. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051113 · Cited by 246 · see citing works

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Marcotte, D. J., Zeng, W., Hus, J., McKenzie, A., Hession, C., Jin, P., Bergeron, C., Lugovskoy, A. A., Enyedy, I. J., Cuervo, H., et al. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.04.019 · Cited by 245 · see citing works

Up-Regulation of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene Involves Binding of Nrf-2 to an Electrophile Responsive Element

Moinova, H., & Mulcahy, R. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1109 · Cited by 245 · see citing works

GSK‐3β down‐regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

Rojo, A. I., de Sagarra, M. R., & Cuadrado, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05124.x · Cited by 241 · see citing works

Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

Kensler, T. W., Egner, P. A., Dolan, P. M., Groopman, J. D., & Roebuck, B. D. (1987) · PubMed · Cited by 240 · see citing works

Can Activation of NRF2 Be a Strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., García‐Yagüe, Á. J., Lastra, D., Manda, G., Rojo, A. I., et al. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.07.003 · Cited by 239 · see citing works

Nrf2 protects against airway disorders

Cho, H., & Kleeberger, S. R. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.024 · Cited by 237 · see citing works

A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas

Hong, D. S., Kurzrock, R., Supko, J. G., He, X., Naing, A., Wheler, J., Lawrence, D., Eder, J. P., Meyer, C. J., Ferguson, D. A., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2703 · Cited by 236 · see citing works

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Sayin, V. I., LeBoeuf, S. E., Singh, S. X., Davidson, S. M., Biancur, D., Guzelhan, B. S., Alvarez, S. W., Wu, W. L., Karakousi, T. R., Zavitsanou, A. M., et al. (2017) · eLife · doi:10.7554/elife.28083 · Cited by 231 · see citing works

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

Peng, C. Y., Stewart, A. G., Woodman, O. L., Ritchie, R. H., & Qin, C. X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603926 · Cited by 230 · see citing works

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova‐Kostova, A. T., Dillon, J. F., Hayes, J. D., & Ashford, M. L. J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00677-14 · Cited by 229 · see citing works

Overcoming the legal and regulatory barriers to drug repurposing

Breckenridge, A. M., & Jacob, R. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.92 · Cited by 228 · see citing works

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

Rojo, A. I., Pajares, M., Rada, P., Núñez, Á., Nevado‐Holgado, A. J., Killick, R., LEUVEN, F. V., Ribé, E. M., Lovestone, S., Yamamoto, M. P., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.006 · Cited by 216 · see citing works

NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism

Fox, D. B., Garcia, N. M. G., McKinney, B. J., Lupo, R., Noteware, L. C., Newcomb, R., Liu, J., Locasale, J. W., Hirschey, M. D., & Alvarez, J. V. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0191-z · Cited by 214 · see citing works

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Neymotin, A., Calingasan, N. Y., Wille, E. J., Naseri, N., Petri, S., Damiano, M. G., Liby, K. T., Risingsong, R., Sporn, M. B., Beal, M. F., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.027 · Cited by 212 · see citing works

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E.-R., Hu, H., Wu, L., Eberhart, C. G., Handa, J. T., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3093-8 · Cited by 211 · see citing works

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism

Kansanen, E., Bonacci, G., Schopfer, F. J., Kuosmanen, S. M., Tong, K. I., Leinonen, H., Woodcock, S. R., Yamamoto, M., Carlberg, C., Ylä-Herttuala, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190710 · Cited by 208 · see citing works

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

Talalay, P., Fahey, J. W., Healy, Z. R., Wehage, S. L., Benedict, A. L., Min, C., & Dinkova‐Kostova, A. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708710104 · Cited by 208 · see citing works

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Hu, L., Magesh, S., Chen, L., Wang, L., Lewis, T. A., Chen, Y., Khodier, C., Inoyama, D., Beamer, L. J., Emge, T. J., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.03.013 · Cited by 206 · see citing works

MOLECULAR EFFECTS of lithium

Quiroz, J. A. (2004) · Molecular Interventions · doi:10.1124/mi.4.5.6 · Cited by 206 · see citing works

Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC

Negrao, M. V., Araujo, H. A., Lamberti, G., Cooper, A. J., Akhave, N. S., Zhou, T., Delasos, L., Hicks, J. K., Aldea, M., Minuti, G., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1420 · Cited by 203 · see citing works

Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

Schipper, H. M., BENNETT, D., Liberman, A., Bienias, J. L., Schneider, J. A., Kelly, J. W., & Arvanitakis, Z. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.016 · Cited by 199 · see citing works

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

Satoh, H., Moriguchi, T., Taguchi, K., Takai, J., Maher, J. M., Suzuki, T., Winnard, P. T., Raman, V., Ebina, M., Nukiwa, T., et al. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq105 · Cited by 197 · see citing works

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

Goven, D., Boutten, A., Leçon-Malas, V., Marchal-Sommé, J., Amara, N., Crestani, B., Fournier, M., Lesèche, G., Soler, P., Boczkowski, J., et al. (2008) · Thorax · doi:10.1136/thx.2007.091181 · Cited by 196 · see citing works

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

Rojo, A. I., Medina‐Campos, O. N., Rada, P., Zúñiga-Toalá, A., López-Gazcón, A., Espada, S., Pedraza‐Chaverrí, J., & Cuadrado, A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.003 · Cited by 195 · see citing works

Nrf2: Molecular and epigenetic regulation during aging

Silva‐Palacios, A., Ostolga-Chavarría, M., Zazueta, C., & Königsberg, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.003 · Cited by 195 · see citing works

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

Horie, Y., Suzuki, T., Inoue, J., Iso, T., Wells, G., Moore, T. W., Mizushima, T., Dinkova‐Kostova, A. T., Kasai, T., Kamei, T., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02100-6 · Cited by 195 · see citing works

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8066 · Cited by 191 · see citing works

NRF2: KEAPing Tumors Protected

Pillai, R., Hayashi, M., Zavitsanou, A.-M., & Papagiannakopoulos, T. Y. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0922 · Cited by 187 · see citing works

Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

Chartoumpekis, D. V., Ziros, P. G., Psyrogiannis, A. I., Papavassiliou, A. G., Kyriazopoulou, V. E., Sykiotis, G. P., & Habeos, I. G. (2011) · Diabetes · doi:10.2337/db11-0112 · Cited by 184 · see citing works

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer

Best, S. A., Gubser, P. M., Sethumadhavan, S., Kersbergen, A. J., Abril, Y. L. N., Goldford, J. E., Sellers, K., Abeysekera, W., Garnham, A. L., McDonald, J. A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.003 · Cited by 184 · see citing works

Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex

Jnoff, E., Albrecht, C., Barker, J. J., Barker, O., Beaumont, E., Bromidge, S. M., Brookfield, F. A., Brooks, M., Bubert, C., Ceska, T., et al. (2014) · ChemMedChem · doi:10.1002/cmdc.201300525 · Cited by 180 · see citing works

Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress

Bellanti, F., Coda, A. R. D., Trecca, M. I., Buglio, A. L., Serviddio, G., & Vendemiale, G. (2025) · Antioxidants · doi:10.3390/antiox14060656 · Cited by 212 · see citing works

Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders

Fahey, J. W., Liu, H., Batt, H., Panjwani, A. A., & Tsuji, P. A. (2025) · Nutrients · doi:10.3390/nu17081353 · Cited by 22 · see citing works

NRF2 as a guardian of health: from an ancient survival pathway to a modern therapeutic target

Tenreiro, S., Falcão, A. S., Bender, N., Bernátová, I., Berry, A., Cuadrado, A., Eppenberger, P., Giona, L., Grochot‐Przeczek, A., Heiß, E. H., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104217 · Cited by 8 · see citing works

Lithium Augmentation in Treatment‐Resistant Depression: A Qualitative Review of the Literature

González, Á. R. A., Guzmán, Y., Proaños, N. J., Bustos, R., Aconcha, M., Guerrero, I. M., Calderon, L. A. M., Berk, M., & Dodd, S. (2025) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.70063 · Cited by 5 · see citing works

Interplay between NRF2 post-translational modifications and protein-protein interactions: Perspectives from emerging structural and functional evidence

Ozleyen, A., Kulabas, S. S., Novak, M. J., Cichoń, M., Heras, C. M. D. L., Honda, T., Doveston, R. G., Dinkova‐Kostova, A. T., Grochot‐Przeczek, A., & Tumer, T. B. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110847 · Cited by 5 · see citing works

Genome-wide mapping of arsenic-activated Nrf2 reveals metabolic and epigenetic reprogramming in induced pluripotent stem cells

Seno, A., Bi, Z., Polin, L., Liu, Z., Qiu, Y., Zhang, W., Pawar, A. S., Thakur, C., Seno, M., Wang, Z., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103773 · Cited by 7 · see citing works

Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2

García‐Yagüe, Á. J., Cueto-Diaz, E. J., Escoll, M., Okunishi, I., Hayes, J. D., Rodrı́guez-Franco, M. I., Rojo, A. I., & Cuadrado, A. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.07.051 · Cited by 4 · see citing works

Intestinal alkaline phosphatase and gut health: insights into homeostasis, barrier protection, and immune signaling

Pang, Y., Tu, J., Zhang, H., Ma, J., Zhang, L., Xue, C., Liu, Y., Hong, W., An, Q., Hui, M., et al. (2026) · Food & Function · doi:10.1039/d5fo03526k · Cited by 1 · see citing works

Sulforaphane Synergies with Phytochemicals and Pharmaceuticals: Implications for Healthspan

Fahey, J. W., & Liu, H. (2026) · Medicines · doi:10.3390/medicines13020016 · Cited by 2 · see citing works

Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture

Qi, G., Ma, T., Wang, Y., Chen, K., Yan, Y., Li, Z., Deng, N., Tseng, C., Li, B., Zheng, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72683-3 · Cited by 2 · see citing works

Cardiometabolic Parameters and Transcription Factors in Rat Models of Prehypertension With or Without Hypertriglyceridemia: Focus on NRF2 and PPARα Gene Expression

Bozkurt, A., Kluknavský, M., Balis, P., Mičurová, A., A, Kopincová, J., & Bernátová, I. (2025) · Physiological Research · doi:10.33549/physiolres.935717 · Cited by 1 · see citing works

Hot−yet−suppressed under PD−1 blockade: an RMP–NRF2–PD−L1 axis associated with a reduced proportional response in hepatocellular carcinoma

Zuo, M., Li, H., Chen, N., Guo, Z., & Wan, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1737569 · Cited by 1 · see citing works

Heme oxygenase-1-enriched tolerogenic dendritic cell-derived exosomes attenuate lupus nephritis by restoring immune balance and iron homeostasis

Xing, Z., Yang, J., Zhang, H., Xie, Y., Yang, Q., Wu, M., Wang, W., Gao, S., & Hua, C. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.04.024 · Cited by 1 · see citing works

Discovery of a Biased Kelch-like ECH-Associated Protein 1–p62 (Keap1–p62) Protein–Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma

Zhao, Z., Lu, H., Zhang, J. Y., Zhao, J., Wang, J., Zhu, T., Xu, S., You, Q., Lu, M., & Jiang, Z. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00096 · Cited by 1 · see citing works

Nrf2-dependent reprogramming of brown adipose tissue in orthotopic breast cancer model: implications for altered systemic homeostasis

Vukobratovic, M., Jevtic, J., Zakić, T., Pekovic‐Vaughan, V., Korać, A., Korać, B., & Janković, A. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104345 · Cited by 1 · see citing works

Triterpenoid CDDO-EA Protects from Hyperglycemia, Hyperinsulinemia, and Obesity by Decreasing Energy Intake

Cantu, A. E., Rasa, C. G., Mito, S., Cantu, D., López-Alvarenga, J. C., Rivera-López, L. L., Rios, I., Abrego-Gonzalez, A., & Reyna, S. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125485

МОЛЕКУЛЯРНИЙ ВОДЕНЬ ЯК МОДУЛЯТОР ОКСИДАТИВНОГО СТРЕСУ ТА ЗАПАЛЕННЯ ПРИ ДОКСОРУБІЦИН-ІНДУКОВАНІЙ ТОКСИЧНОСТІ

Зигрій, Н. В., & Shevchuk, O. O. (2025) · Здобутки клінічної і експериментальної медицини · doi:10.11603/1811-2471.2025.v.i3.15557

Can’t KEEP Up: UXS1 Dependency Exposes a Pyrimidine Vulnerability in KEAP1 -Mutant Lung Cancer

Yasseen, B. A., & DeNicola, G. M. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-3547

Enterolactone mitigates atherosclerosis by facilitating resolution of ferroptosis-associated intimal inflammation via the Keap1/Nrf2/GPX4 pathway

Chai, S., Zhang, Y., Guo, Y., Cao, D., Wang, J., Yan, Y., Shi, Y., Yuan, Z., Wang, X., Tong, T., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158178

Targeting antioxidant mechanisms in myocardial ischemia-reperfusion injury: A review of therapeutic strategies and clinical progress

Wang, J., Li, H., Shao, Q., Zhao, Y., Yang, X., Fan, M., Gan, H., Tang, Q., Jiang, S., & Xie, J. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179009

Estrogen receptors and the NRF2 pathway: bridging hormonal regulation and stress response in the gut

Kopacz, A., Tomaszewska, Z., & Piechota-Polańczyk, A. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1861565

The utility of FRET/FLIM-based bioassays for monitoring Nrf2 activation in single live cells

Dikovskaya, D., & Dinkova‐Kostova, A. T. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.08.005

Systemic redox switching of transcription factors: A context-sensitive framework for cell fate decisions

Dimova, E. Y., & Kietzmann, T. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104348

Neuroinflammation and vascular pathology in Alzheimer's Disease: The NRF2/HO-1 axis as a modulator of microglial phenotypes

Olazabal-Chias, M., Kratochvil, M., & Rojo, A. I. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106258

Dual promoter architecture of NFE2L2 underlies isoform-specific translational control of NRF2

Sznarkowska, A., Urban-Wójciuk, Z., Dziadosz-Brzezińska, A., Cieśla, M., Kusiński, S., Wakimian, K., Szabelska-Beręsewicz, A., Chruściel, E., Papak, I., Marek-Trzonkowska, N., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104405

Hepatocyte-Specific Nrf2 Deficiency Alters Cholesterol Metabolism, Leading to Mitigated Atherosclerosis in ApoE-Knockout Mice

Jiao, J., Xu, N., Hong, Z., Chang, L., Huang, D., Yu, Y., Wang, Z., Li, Y., Yu, J., Guo, J., et al. (2026) · Antioxidants · doi:10.3390/antiox15091183

Integrated roles of the thioredoxin-related protein of 14 kDa, TRP14, in sulfur amino acid metabolism, protein posttranslational modifications and signaling

Sastre, J., Simmons, A. J., Miranda‐Vizuete, A., Arnér, E. S. J., Nagy, P., Martı́nez-Ruiz, A., & Schmidt, E. E. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.10.033

HIF-1α–Nrf2 crosstalk in myocardial ischemia–reperfusion injury: a potential preconditioning-responsive protective network

Guo, X., Wang, C., 张舒岩, Li, M., & Chen, C. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1976117

Advances and challenges in therapeutic targeting of NRF2

Dinkova‐Kostova, A. T., & Copple, I. M. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.12.003 · Cited by 272 · see citing works

NRF2: Master regulator of cellular homeostasis and therapeutic vulnerability in cancer

Chen, W.-T., McKee, N. W., Kuhnell, D., & Dodson, M. B. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104050 · Cited by 26 · see citing works

Modulating NRF2 in Disease: Timing Is Everything

Dodson, M. B., de la Vega, M. R., Cholanians, A. B., Schmidlin, C. J., Chapman, E., & Zhang, D. D. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021856 · Cited by 540 · see citing works

Perspectives on the Clinical Development of NRF2-Targeting Drugs

Lastra, D., Fernández-Ginés, R., Manda, G., & Cuadrado, A. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_381 · Cited by 28 · see citing works

Introduction to Special Issue on “Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases”

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