Schildknecht, Stefan

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., et al. (2017) · Archives of Toxicology

Animal testing and alternativesAgricultural safety and regulations

Cited by 394

In Vitro research Reproducibility: Keeping up High Standards

Hirsch, C., & Schildknecht, S. (2019) · Frontiers in Pharmacology

Animal testing and alternativesViral Infectious Diseases and Gene Expression in Insects

Cited by 161

Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

Schildknecht, S., Gerding, H. R., Karreman, C., Drescher, M., Lashuel, H. A., Outeiro, T. F., Di Monte, D. A., & Leist, M. (2013) · Journal of Neurochemistry

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 148

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

Hoelting, L., Scheinhardt, B., Bondarenko, O., Schildknecht, S., Kapitza, M., Tanavde, V., Tan, B., Lee, Q. Y., Mecking, S., Leist, M., et al. (2013) · Archives of Toxicology

Pluripotent Stem Cells ResearchAnimal testing and alternatives

Cited by 129

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Members, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology

Parkinson's Disease Mechanisms and TreatmentsPesticide Exposure and Toxicity

Cited by 124

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

Schildknecht, S., Pöltl, D., Nagel, D. M., Matt, F., Scholz, D., Lotharius, J., Schmieg, N., Salvo-Vargas, A., & Leist, M. (2009) · Toxicology and Applied Pharmacology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 115

Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS‐activator peroxynitrite

Schildknecht, S., Daiber, A., Ghisla, S., Cohen, R. A., & Bachschmid, M. M. (2008) · The FASEB Journal

Inflammatory mediators and NSAID effectsRedox biology and oxidative stress

Cited by 57

The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite

Schildknecht, S., Weber, A., Gerding, H., Pape, R., Robotta, M., Drescher, M., Marquardt, A., Daiber, A., Ferger, B., & Leist, M. (2013) · Current Medicinal Chemistry

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 55

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

Pöltl, D., Schildknecht, S., Karreman, C., & Leist, M. (2012) · NeuroToxicology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 49