Neefjes, Jacques

Towards a systems understanding of MHC class I and MHC class II antigen presentation

Neefjes, J., Jongsma, M. L. M., Paul, P., & Bakke, O. (2011) · Nature Reviews Immunology

Immunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Cited by 2,044

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

Reits, E. A., Hodge, J. W., Herberts, C. A., Groothuis, T. A., Chakraborty, M., K.Wansley, E., Camphausen, K., Luiten, R. M., de Ru, A. H., Neijssen, J., et al. (2006) · The Journal of Experimental Medicine

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 1,737

Present yourself! by MHC class I and MHC class II molecules

Rock, K. L., Reits, E., & Neefjes, J. (2016) · Trends in Immunology

Immunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Cited by 814

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors

Jordens, I., Fernandez-Borja, M., Marsman, M., Dusseljee, S., Janssen, L., Calafat, J., Janssen, H., Wubbolts, R., & Neefjes, J. (2001) · Current Biology

Cellular transport and secretionMicrotubule and mitosis dynamics

Cited by 811

Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin

Johansson, M., Rocha, N., Zwart, W., Jordens, I., Janssen, L., Kuijl, C., Olkkonen, V. M., & Neefjes, J. (2007) · The Journal of Cell Biology

Cellular transport and secretionMicrotubule and mitosis dynamics

Cited by 505

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

Huang, S., Hölzel, M., Knijnenburg, T., Schlicker, A., Roepman, P., McDermott, U., Garnett, M., Grernrum, W., Sun, C., Prahallad, A., et al. (2012) · Cell

TGF-β signaling in diseasesLung Cancer Treatments and Mutations

Cited by 430

Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer

Berner, F., Bomze, D., Diem, S., Ali, O. H., Fässler, M., Ring, S., Niederer, R., Ackermann, C. J., Baumgaertner, P., Pikor, N., et al. (2019) · JAMA Oncology

Cancer Immunotherapy and BiomarkersChemotherapy-related skin toxicity

Cited by 395

Collateral damage: Insights into bacterial mechanisms that predispose host cells to cancer

Gagnaire, A., Nadel, B., Raoult, D., Neefjes, J., & Gorvel, J.-P. (2017) · Nature Reviews Microbiology

Helicobacter pylori-related gastroenterology studiesBacterial Cancer Therapy

Cited by 189

Increased colon cancer risk after severe Salmonella infection

Mughini-Gras, L., Schaapveld, M., Kramers, J., Mooij, S., Neefjes-Borst, E. A., Pelt, W. V., & Neefjes, J. (2018) · PLoS ONE

Salmonella and Campylobacter epidemiologyColorectal Cancer Screening and Detection

Cited by 133

Opportunities for Small Molecules in Cancer Immunotherapy

van der Zanden, S. Y., Luimstra, J. J., Neefjes, J., Borst, J., & Ovaa, H. (2020) · Trends in Immunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 119

Presentation of Cytosolic Glycosylated Peptides by Human Class I Major Histocompatibility Complex Molecules in Vivo

Haurum, J. S., Høier, I. B., Arsequell, G., Neisig, A., Valencia, G., Zeuthen, J., Neefjes, J., & Elliott, T. (1999) · The Journal of Experimental Medicine

Glycosylation and Glycoproteins ResearchImmunotherapy and Immune Responses

Cited by 106

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis

van Luijn, M. M., Kreft, K. L., Jongsma, M. L., Mes, S. W., Wierenga-Wolf, A. F., van Meurs, M., Melief, M.-J., der Kant, R. V., Janssen, L., Janssen, H., et al. (2015) · Brain

Multiple Sclerosis Research StudiesImmunotherapy and Immune Responses

Cited by 68

RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress

Cremer, T., Voortman, L. M., Bos, E., Jongsma, M. L., ter Haar, L. R., Akkermans, J. J., Talavera Ormeño, C. M., Wijdeven, R. H., de Vries, J., Kim, R. Q., et al. (2023) · The EMBO Journal

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretion

Cited by 35

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Cabukusta, B., Borst Pauwels, S., Akkermans, J. J., Blomberg, N., Mulder, A. A., Koning, R. I., Giera, M., & Neefjes, J. (2024) · eLife

Sphingolipid Metabolism and SignalingLipid metabolism and biosynthesis

Cited by 8