Walsh, Kenneth

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 4,625

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 3,012

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science

Atherosclerosis and Cardiovascular DiseasesAcute Myeloid Leukemia Research

Cited by 1,536

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine

Cardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

Cited by 982

Cardiomyocyte Grafting for Cardiac Repair: Graft Cell Death and Anti-Death Strategies

Zhang, M., Methot, D., Poppa, V., Fujio, Y., Walsh, K., & Murry, C. E. (2001) · Journal of Molecular and Cellular Cardiology

Congenital heart defects researchTissue Engineering and Regenerative Medicine

Cited by 878

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T. J., et al. (2008) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 778

Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry

Angiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 759

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

Sano, S., Oshima, K., Wang, Y., MacLauchlan, S., Katanasaka, Y., Sano, M., Zuriaga, M. A., Yoshiyama, M., Goukassian, D., Cooper, M. A., et al. (2018) · Journal of the American College of Cardiology

Cardiac Fibrosis and RemodelingAcute Myeloid Leukemia Research

Cited by 699

Adiponectin-mediated modulation of hypertrophic signals in the heart

Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine

Cardiac Fibrosis and RemodelingAdipokines, Inflammation, and Metabolic Diseases

Cited by 671

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

Ohashi, K., Parker, J. L., Ouchi, N., Higuchi, A., Vita, J. A., Gokce, N., Pedersen, A. A., Kalthoff, C., Tullin, S., Sams, A., et al. (2010) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 646

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease

Sano, S., Oshima, K., Wang, Y., Katanasaka, Y., Sano, M., & Walsh, K. (2018) · Circulation Research

Acute Myeloid Leukemia ResearchCRISPR and Genetic Engineering

Cited by 417

FGF21 is an Akt‐regulated myokine

Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters

Fibroblast Growth Factor ResearchMuscle Physiology and Disorders

Cited by 415

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., et al. (2006) · Hypertension

Adipokines, Inflammation, and Metabolic DiseasesBlood Pressure and Hypertension Studies

Cited by 400

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

Izumiya, Y., Hopkins, T., Morris, C., Sato, K., Zeng, L., Viereck, J., Hamilton, J. A., Ouchi, N., LeBrasseur, N. K., & Walsh, K. (2008) · Cell Metabolism

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 395

Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism

Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry

Angiogenesis and VEGF in CancerNitric Oxide and Endothelin Effects

Cited by 338

Adiponectin Stimulates Angiogenesis in Response to Tissue Ischemia through Stimulation of AMP-activated Protein Kinase Signaling

Shibata, R., Ouchi, N., Kihara, S., Sato, K., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesAngiogenesis and VEGF in Cancer

Cited by 336

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress

Nagata, D., Mogi, M., & Walsh, K. (2003) · Journal of Biological Chemistry

Angiogenesis and VEGF in CancerMetabolism, Diabetes, and Cancer

Cited by 331

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Naito, A. T., Sumida, T., Nomura, S., Liu, M.-L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., et al. (2012) · Cell

Wnt/β-catenin signaling in development and cancerGenetics, Aging, and Longevity in Model Organisms

Cited by 320

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

Craige, S. M., Chen, K., Pei, Y., Li, C., Huang, X., Chen;, C., Shibata, R., Sato, K., Walsh, K., & Keaney, J. F. (2011) · Circulation

Nitric Oxide and Endothelin EffectsAngiogenesis and VEGF in Cancer

Cited by 283

Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart

Oshima, Y., Ouchi, N., Sato, K., Izumiya, Y., Pimentel, D. R., & Walsh, K. (2008) · Circulation

Cardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

Cited by 275

TET2-loss-of-function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity

Fuster, J. J., Zuriaga, M. A., Zorita, V., MacLauchlan, S., Polackal, M. N., Viana-Huete, V., Ferrer-Pérez, A., Matesanz, N., Herrero-Cervera, A., Sano, S., et al. (2020) · Cell Reports

Adipokines, Inflammation, and Metabolic DiseasesAcute Myeloid Leukemia Research

Cited by 204

Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress

Ngoh, G. A., Papanicolaou, K. N., & Walsh, K. (2012) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and Pathology

Cited by 183

Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models

Ogura, Y., Ouchi, N., Ohashi, K., Shibata, R., Kataoka, Y., Kambara, T., Kito, T., Maruyama, S., Yuasa, D., Matsuo, K., et al. (2012) · Circulation

Cardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

Cited by 183

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

Wang, C.-Y., Kim, H.-H., Hiroi, Y., Sawada, N., Salomone, S., Benjamin, L. E., Walsh, K., Moskowitz, M. A., & Liao, J. K. (2009) · Science Signaling

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 177