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Cited by 400Adipokines, Inflammation, and Metabolic DiseasesBlood Pressure and Hypertension StudiesCardiovascular Disease and Adiposity

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, Koji, Kihara, Shinji, Ouchi, Noriyuki, Kumada, Masahiro, Fujita, Koichi, Hiuge, Aki, Hibuse, Toshiyuki, Ryo, Miwa +7 more·2006·Hypertension
DOI 10.1161/01.hyp.0000222368.43759.a1
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Abstract

Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties against obesity-related diseases, such as type 2 diabetes and coronary artery disease. The aim of this study was to determine the relationship between adiponectin and hypertension in mice. We measured blood pressure and heart rate directly by a catheter in the carotid artery and indirectly by automatic sphygmomanometer at the tail artery. Obese KKAy mice had significantly lower plasma adiponectin levels and higher systolic blood pressure than control C57BL/6J mice at 21 weeks of age. Adenovirus-delivered adiponectin significantly decreased blood pressure in KKAy mice. The direct role of adiponectin on blood pressure regulation under insulin resistance–free state was investigated in adiponectin-knockout (KO) mice. Adiponectin KO mice developed hypertension when maintained on a high-salt diet (8% NaCl) without insulin resistance. The hypertension of salt-fed adiponectin KO mice was associated with reduced mRNA levels of endothelial NO synthase (eNOS) and prostaglandin I 2 synthase in aorta and low metabolite levels of endothelial NO synthase and prostaglandin I 2 synthase in plasma. Adiponectin therapy lowered the elevated blood pressure and corrected the above mRNA levels to those of the wild type. Our results suggest that hypoadiponectinemia contributes to the development of obesity-related hypertension, at least in part, directly, in addition to its effect via insulin resistance, and that adiponectin therapy can be potentially useful for hypertension in patients with the metabolic syndrome.

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Crossref · 10.1161/01.hyp.0000222368.43759.a1

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  • Adiponectin supplementation reduced blood pressure in salt-fed adiponectin-knockout mice and in KKAy mice, which develop obesity via ectopic expression of agouti protein.

    “Adiponectin supplementation reduced BP in salt-fed, adiponectin-knockout mice and in KKAy mice, which develop obesity via ectopic expression of agouti protein117.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [117]

  • Adiponectin-knockout mice had normal blood pressure when maintained on a normal salt intake but had greater increases in blood pressure than control mice when fed a high-salt diet.

    “The role of adiponectin in cardiometabolic regulation was examined in adiponectin-knockout mice, which had normal BP when maintained on a normal salt intake117. By contrast, when fed a high-salt diet, these mice had greater increases in BP than did control mice, suggesting salt sensitivity of BP.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [117]

  • Antidiabetic, anti-inflammatory, and antihypertensive effects have all been established to occur in response to adiponectin.

    “Antidiabetic (162), anti-inflammatory (348), and antihypertensive (259) effects have all been established to occur in response to adiponectin.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [259]

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Authors
Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., Maeda, K., Shibata, R., Walsh, K., Funahashi, T., & Shimomura, I.
Affiliations
Boston University (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-06
Volume
47
Issue
6
Pages
1108-1116
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000222368.43759.a1
OpenAlex
W2166751358
Cited by
400
References
36
Citations by year
2026: 5 · 2025: 11 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 61 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 25 · 2013: 22 · 2012: 30
FWCI
24.90
Type
journal article
Language
en
Update notices
correction (2006-12-26)
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adiponectin, obesity-related hypertension, hypoadiponectinemia, KK-Ay mice, adiponectin knockout mice, high-salt diet, endothelial nitric oxide synthase, PTGIS, nitric oxide, insulin resistance, metabolic syndrome, blood pressure regulation
MeSH terms
Adenoviridae, Animals, Aorta, Blood Pressure, Cytochrome P-450 Enzyme System, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Enzyme Inhibitors, Genetic Vectors, Hypertension, Insulin Resistance, Male, Mice, Inbred Strains, Obesity, RNA, Messenger, Sodium Chloride, Dietary, Gene Transfer Techniques, Mice, Knockout, NG-Nitroarginine Methyl Ester, Intramolecular Oxidoreductases, Mice, Adiponectin, Nitric Oxide Synthase Type III

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