AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress

Mechanisms of angiogenesis and arteriogenesis

Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,146 · see citing works

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591 · see citing works

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 2,985 · see citing works

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,612 · see citing works

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Gerber, H. P., McMurtrey, A. E., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V. M., & Ferrara, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30336 · Cited by 1,976 · see citing works

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438 · see citing works

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264 · see citing works

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,201 · see citing works

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C., Buerk, D. G., Huang, P. L., & Jain, R. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041359198 · Cited by 1,020 · see citing works

Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

Shiojima, I., & Walsh, K. (2002) · Circulation Research · doi:10.1161/01.res.0000022200.71892.9f · Cited by 1,011 · see citing works

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Dorpe, J. V., Hellings, P., Gorselink, M., Heymans, S., et al. (2001) · Nature Genetics · doi:10.1038/88842 · Cited by 1,007 · see citing works

Clinical applications of angiogenic growth factors and their inhibitors

Ferrara, N., & Alitalo, K. (1999) · Nature Medicine · doi:10.1038/70928 · Cited by 1,004 · see citing works

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works

HIF-1 and human disease: one highly involved factor

Semenza, G. L. (2000) · Genes & Development · doi:10.1101/gad.14.16.1983 · Cited by 909 · see citing works

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diab.47.8.1369 · Cited by 774 · see citing works

Phosphorylation of Thr ⁴⁹⁵ Regulates Ca ²⁺ /Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity

Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1101.092677 · Cited by 770 · see citing works

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

Kudo, N., Barr, A., Barr, R. L., Desai, S. S., & Lopaschuk, G. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17513 · Cited by 565 · see citing works

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

Michell, B. J., Chen, Z., Tiganis, T., Stapleton, D., Katsis, F., Power, D. A., Sim, A. T. R., & Kemp, B. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100122200 · Cited by 560 · see citing works

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

Fujio, Y., & Walsh, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16349 · Cited by 552 · see citing works

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

Jiang, B., Zheng, J. Z., Aoki, M., & Vogt, P. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040560897 · Cited by 524 · see citing works

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

Toker, A., & Newton, A. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8271 · Cited by 522 · see citing works

Purification and characterization of the AMP‐activated protein kinase

Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418 · see citing works

Vascular Endothelial Growth Factor–Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt

Morales‐Ruiz, M., Fulton, D. J., Sowa, G., Languino, L. R., Fujio, Y., Walsh, K., & Sessa, W. C. (2000) · Circulation Research · doi:10.1161/01.res.86.8.892 · Cited by 418 · see citing works

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target

Muoio, D. M., Seefeld, K. J., Witters, L. A., & Coleman, R. (1999) · Biochemical Journal · doi:10.1042/bj3380783 · Cited by 409 · see citing works

Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise

Park, H., Kaushik, V. K., Constant, S., Prentki, M., Przybytkowski, E., Ruderman, N. B., & Saha, A. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201692200 · Cited by 384 · see citing works

Phosphorylation of the endothelial nitric oxide synthase at Ser‐1177 is required for VEGF‐induced endothelial cell migration

Dimmeler, S., Dernbach, E., & Zeiher, A. M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01657-4 · Cited by 363 · see citing works

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

Mitchelhill, K. I., Stapleton, D., Gao, G., House, C. M., Michell, B. J., Katsis, F., Witters, L. A., & Kemp, B. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41951-x · Cited by 338 · see citing works

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323 · see citing works

Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver.

Clarke, P. R., & Hardie, D. G. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07420.x · Cited by 322 · see citing works

Increased Adenosine Monophosphate–Activated Protein Kinase Activity in Rat Hearts With Pressure-Overload Hypertrophy

Tian, R., Musi, N., D’Agostino, J., Hirshman, M. F., & Goodyear, L. J. (2001) · Circulation · doi:10.1161/hc4001.097183 · Cited by 308 · see citing works

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

Carling, D., & Grahame Hardie, D. (1989) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(89)90014-1 · Cited by 296 · see citing works

Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase

DAVIES, S. P., SIM, A. T. R., & HARDIE, D. G. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15293.x · Cited by 274 · see citing works

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism

Carling, D., Aguan, K., Woods, A., Verhoeven, A., Beri, R. K., Brennan, C. H., Sidebottom, C., Davison, M. D., & Scott, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78143-5 · Cited by 253 · see citing works

Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

Kudo, N., Gillespie, J. G., Kung, L., Witters, L. A., Schulz, R., Clanachan, A. S., & Lopaschuk, G. D. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00013-6 · Cited by 246 · see citing works

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP‐activated protein kinase: A sensitive mechanism to protect the cell against ATP depletion

MOORE, F., WEEKES, J., & HARDIE, D. G. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16172.x · Cited by 223 · see citing works

Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells

Radisavljevic, Z., Avraham, H. K., & Avraham, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002448200 · Cited by 221 · see citing works

Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival

Fujio, Y., Guo, K. Y., Mano, T., Mitsuuchi, Y., Testa, J. R., & Walsh, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.5073 · Cited by 213 · see citing works

Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

Luo, Z., Fujio, Y., Kureishi, Y., Rudic, R. D., Daumerie, G., Fulton, D. J., Sessa, W. C., & Walsh, K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9419 · Cited by 212 · see citing works

Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells

Dagher, Z., Ruderman, N. B., Tornheim, K., & Ido, Y. (2001) · Circulation Research · doi:10.1161/hh1201.092998 · Cited by 209 · see citing works

Modulation by Peroxynitrite of Akt- and AMP-activated Kinase-dependent Ser1179 Phosphorylation of Endothelial Nitric Oxide Synthase

Zou, M., Hou, X., Shi, C., Nagata, D., Walsh, K., & Cohen, R. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204512200 · Cited by 189 · see citing works

Podokinesis in endothelial cell migration: role of nitric oxide

Noiri, E., Lee, E., Testa, J. E., Quigley, J. P., Colflesh, D. E., Keese, C. R., Giæver, I., & Goligorsky, M. S. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.1.c236 · Cited by 181 · see citing works

Vascular Endothelial Growth Factor–Induced Endothelial Cell Migration and Proliferation Depend on a Nitric Oxide–Mediated Decrease in Protein Kinase Cδ Activity

Shizukuda, Y., Tang, S., Yokota, R., & Ware, J. A. (1999) · Circulation Research · doi:10.1161/01.res.85.3.247 · Cited by 174 · see citing works

Myogenic Akt Signaling Regulates Blood Vessel Recruitment during Myofiber Growth

Takahashi, A., Kureishi, Y., Jiang, Y., Luo, Z., Guo, K. Y., Mukhopadhyay, D., Ivashchenko, Y., Branellec, D., & Walsh, K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4803-4814.2002 · Cited by 159 · see citing works

VEGF 165 Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo

Mühlhauser, J., Merrill, M. J., Пили, Р., Maeda, H., Bacic, M., Bewig, B., Passaniti, A., Edwards, N. A., Crystal, R. G., & Capogrossi, M. C. (1995) · Circulation Research · doi:10.1161/01.res.77.6.1077 · Cited by 154 · see citing works

Signaling Angiogenesis via p42/p44 MAP Kinase Cascade

Pagès, G., Milanini, J., Richard, D. E., Berra, E., Gothié, E., Viñals, F., & Pouysségur, J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06313.x · Cited by 135 · see citing works

Expression of the AMP‐activated protein kinase β1 and β2 subunits in skeletal muscle

Chen, Z., Heierhorst, J., Mann, R. J., Mitchelhill, K. I., Michell, B. J., Witters, L. A., Lynch, G. S., Kemp, B. E., & Stapleton, D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01371-x · Cited by 134 · see citing works

Angiogenesis in Embryos and Ischemic Diseases

Breier, G., Damert, A., Plate, K. H., & Risau, W. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657611 · Cited by 130 · see citing works

Regulation of Angiogenesis by Glycogen Synthase Kinase-3β

Kim, H.-S., Skurk, C., Thomas, S. R., Bialik, A., Suhara, T., Kureishi, Y., Birnbaum, M. J., Keaney, J. F., & Walsh, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206657200 · Cited by 123 · see citing works

Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis

Rikitake, Y., Hirata, K., Kawashima, S., Ozaki, M., Takahashi, T., Ogawa, W., Inoue, N., & Yokoyama, M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101843 · Cited by 122 · see citing works

Control of Hepatic Fatty Acid Oxidation by 5′-AMP-Activated Protein Kinase Involves a Malonyl-CoA-Dependent and a Malonyl-CoA-Independent Mechanism

Velasco, G., Geelen, M. J. H., & Guzmán, M. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9784 · Cited by 115 · see citing works

Decorin-mediated Signal Transduction in Endothelial Cells

Schönherr, E., Levkau, B., Schaefer, L., Kresse, H., & Walsh, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105426200 · Cited by 110 · see citing works

The Effect of AMP-Activated Protein Kinase and Its Activator AICAR on the Metabolism of Human Umbilical Vein Endothelial Cells

Dagher, Z., Ruderman, N. B., Tornheim, K., & Ido, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1635 · Cited by 95 · see citing works

Hypoxia-induced adrenomedullin production in the kidney

Nagata, D., Hirata, Y., Suzuki, E., Kakoki, M., Hayakawa, H., Goto, A., Ishimitsu, T., Minamino, N., Ono, Y., Kangawa, K., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00361.x · Cited by 87 · see citing works

Activation of rat liver AMP‐activated protein kinase by kinase kinase in a purified, reconstituted system

WEEKES, J., Hawley, S. A., Corton, J. M., Shugar, D., & Hardie, D. G. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18554.x · Cited by 84 · see citing works

Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor

Witzenbichler, B., Kureishi, Y., Luo, Z., Roux, A. L., Branellec, D., & Walsh, K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7251 · Cited by 80 · see citing works

Amyloid‐β‐induced Degeneration of Human Brain Pericytes Is Dependent on the Apolipoprotein E Genotype

Verbeek, M. M., Nostrand, W. E. V., Otte‐Höller, I., Wesseling, P., & de Waal, R. M. W. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06368.x · Cited by 55 · see citing works

Cyclin A Downregulation and p21 cip1 Upregulation Correlate With GATA-6–Induced Growth Arrest in Glomerular Mesangial Cells

Nagata, D., Suzuki, E., Nishimatsu, H., Yoshizumi, M., Mano, T., Walsh, K. X., Sata, M., Kakoki, M., Goto, A., Omata, M., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.8.699 · Cited by 32 · see citing works

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

Towler, M. C., & Hardie, D. G. (2007) · Circulation Research · doi:10.1161/01.res.0000256090.42690.05 · Cited by 1,248 · see citing works

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works

Mechanisms of Vascular Aging

Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919 · see citing works

Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310389200 · Cited by 759 · see citing works

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Donato, A. J., Machin, D. R., & Lesniewski, L. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312563 · Cited by 699 · see citing works

Adiponectin-mediated modulation of hypertrophic signals in the heart

Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671 · see citing works

Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin

Kobayashi, H., Ouchi, N., Kihara, S., Walsh, K., Kumada, M., Abe, Y., Funahashi, T., & Matsuzawa, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000119921.86460.37 · Cited by 658 · see citing works

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100966 · Cited by 585 · see citing works

Cellular and molecular biology of aging endothelial cells

Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works

Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase

Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 467 · see citing works

AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells

Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K. X., Herscovitz, H., Brecher, P. I., Ruderman, N. B., & Cohen, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408149200 · Cited by 450 · see citing works

5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

Laderoute, K. R., Amin, K., Calaoagan, J. M., Knapp, M., Le, T., Orduna, J. M., Foretz, M., & Viollet, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-06 · Cited by 443 · see citing works

Akt Activity Negatively Regulates Phosphorylation of AMP-activated Protein Kinase in the Heart

Kovacic, S., Soltys, C.-L. M., Barr, A., Shiojima, I., Walsh, K., & Dyck, J. R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305371200 · Cited by 407 · see citing works

AMPK inhibition in health and disease

Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.488215 · Cited by 383 · see citing works

The Link Between Angiogenesis and Endothelial Metabolism

Potente, M., & Carmeliet, P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105134 · Cited by 353 · see citing works

Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491

Horman, S., Vertommen, D., Heath, R. B., Neumann, D., Mouton, V., Woods, A., Schlattner, U., Wallimann, T., Carling, D., Hue, L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506850200 · Cited by 345 · see citing works

Adiponectin Stimulates Angiogenesis in Response to Tissue Ischemia through Stimulation of AMP-activated Protein Kinase Signaling

Shibata, R., Ouchi, N., Kihara, S., Sato, K., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402558200 · Cited by 336 · see citing works

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Emerling, B. M., Weinberg, F., Snyder, C., Burgess, Z., Mutlu, G. M., Viollet, B., Budinger, G. R. S., & Chandel, N. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.019 · Cited by 330 · see citing works

Adiponectin actions in the cardiovascular system

Hopkins, T. A., Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.009 · Cited by 326 · see citing works

Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells

Fleming, I., Fißlthaler, B., Dixit, M., & Busse, R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02541 · Cited by 328 · see citing works

Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity In Vivo

Rattan, R., Graham, R. P., Maguire, J. L., Giri, S., & Shridhar, V. (2011) · Neoplasia · doi:10.1593/neo.11148 · Cited by 316 · see citing works

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

Fisslthaler, B., & Fleming, I. (2009) · Circulation Research · doi:10.1161/circresaha.109.201590 · Cited by 295 · see citing works

AMPK, Mitochondrial Function, and Cardiovascular Disease

Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

Storozhuk, Y., Hopmans, S., Sanli, T., Barron, C. C., Tsiani, E., Cutz, J.-C., Pond, G. R., Wright, J. R., Singh, G., & Tsakiridis, T. K. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.187 · Cited by 272 · see citing works

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

Satoh, H., Nguyen, M. T., Miles, P. D. G., Imamura, T., Usui, I., & Olefsky, J. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20785 · Cited by 266 · see citing works

Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes

Ong, K. W., Hsu, A., & Tan, B. K. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032718 · Cited by 270 · see citing works

Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model

Tanaka, T., Kojima, I., Ohse, T., Ingelfinger, J. R., Adler, S., Fujita, T., & Nangaku, M. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700328 · Cited by 238 · see citing works

AMP-Activated Protein Kinase Signaling Stimulates VEGF Expression and Angiogenesis in Skeletal Muscle

Ouchi, N., Shibata, R., & Walsh, K. (2005) · Circulation Research · doi:10.1161/01.res.0000163633.10240.3b · Cited by 238 · see citing works

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

Li, X., Song, J., Zhang, L., LeMaire, S. A., Hou, X., Zhang, C., Coselli, J. S., Chen, L., Wang, X. L., Zhang, Y., et al. (2009) · Diabetes · doi:10.2337/db08-1512 · Cited by 237 · see citing works

Human Umbilical Vein Endothelial Cells and Human Dermal Microvascular Endothelial Cells Offer New Insights Into the Relationship Between Lipid Metabolism and Angiogenesis

Park, G.-H., Zhang, Y., Georgescu, S. P., Johnson, K. L., Kong, D., & Galper, J. (2006) · Stem Cell Reviews and Reports · doi:10.1007/s12015-006-0015-x · Cited by 223 · see citing works

Thrombin Activates AMP-Activated Protein Kinase in Endothelial Cells via a Pathway Involving Ca2+/Calmodulin-Dependent Protein Kinase Kinase β

Stahmann, N., Woods, A., Carling, D., & Heller, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00383-06 · Cited by 214 · see citing works

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress

Zhang, Y., Lee, T.-S., Kolb, E. M., Sun, K., Lu, X., Sladek, F. M., Kassab, G. S., Garland, T., & Shyy, J. Y.-J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000221230.08596.98 · Cited by 212 · see citing works

Adipokine resistin promotes in vitro angiogenesis of human endothelial cells

Mu, H. H., OHASHI, R., YAN, S., Chai, H., Yang, H., LIN, P., YAO, Q., & CHEN, C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.015 · Cited by 209 · see citing works

CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis

Jiang, T.-X., Zhuang, J., Duan, H., Luo, Y., Zeng, Q., Fan, K., Yan, H., Lü, D., Ye, Z., Hao, J., et al. (2012) · Blood · doi:10.1182/blood-2012-01-406108 · Cited by 209 · see citing works

Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells

Levine, Y. C., Li, G. K., & Michel, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702182200 · Cited by 207 · see citing works

AMP-Activated Protein Kinase Inhibits Angiotensin II–Stimulated Vascular Smooth Muscle Cell Proliferation

Nagata, D., Takeda, R., Sata, M., Satonaka, H., Suzuki, E., Nagano, T., & Hirata, Y. (2004) · Circulation · doi:10.1161/01.cir.0000136025.96811.76 · Cited by 198 · see citing works

Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers

Gray, D., Jubb, A. M., Hogue, D. A., Dowd, P., Kljavin, N. M., Yi, S., Bai, W., Frantz, G. D., Zhang, Z., Koeppen, H., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4531 · Cited by 190 · see citing works

Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

Yu, J., Deng, Y., Han, X., Ren, G., Cai, J., & Jiang, G. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0408-3 · Cited by 188 · see citing works

AMP-Activated Protein Kinase

Salt, I. P., & Hardie, D. G. (2017) · Circulation Research · doi:10.1161/circresaha.117.309633 · Cited by 186 · see citing works

AMPK, metabolism, and vascular function

Rodríguez, C., Muñoz, M., Contreras, C., & Prieto, D. (2021) · FEBS Journal · doi:10.1111/febs.15863 · Cited by 178 · see citing works

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model

Phoenix, K. N., Vumbaca, F., & Claffey, K. P. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-9916-5 · Cited by 173 · see citing works

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival

Liu, X., Peyton, K. J., Shebib, A. R., Wang, H., Korthuis, R. J., & Durante, W. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2010 · Cited by 171 · see citing works

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.255 · Cited by 163 · see citing works

AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review

Višnjić, D., Lalić, H., Dembitz, V., Tomić, B., & Smoljo, T. (2021) · Cells · doi:10.3390/cells10051095 · Cited by 164 · see citing works

Glycogen-Synthase Kinase3β/β-Catenin Axis Promotes Angiogenesis Through Activation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

Skurk, C., Maatz, H., Rocnik, E. F., Bialik, A., Force, T. L., & Walsh, K. (2005) · Circulation Research · doi:10.1161/01.res.0000156273.30274.f7 · Cited by 164 · see citing works

AMP‐activated protein kinase and cancer

Wang, W., & Guan, K. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01980.x · Cited by 163 · see citing works

AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts

Lee, Y., Kim, Y.-S., Lee, S.-Y., Kim, G.-H., Kim, B., Lee, S., Lee, K., Kim, G.-S., Kim, S., & Koh, J. (2010) · Bone · doi:10.1016/j.bone.2010.08.001 · Cited by 152 · see citing works

Paradoxic effects of metformin on endothelial cells and angiogenesis

Dallaglio, K., Bruno, A., Cantelmo, A. R., Esposito, A. I., Ruggiero, L., Orecchioni, S., Calleri, A., Bertolini, F., Pfeffer, U., Noonan, D. M., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu001 · Cited by 146 · see citing works

CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

Frigo, D. E., Howe, M. K., Wittmann, B. M., Brunner, A. M., Cushman, I., Wang, Q., Brown, M. A., Means, A. R., & McDonnell, D. P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2581 · Cited by 140 · see citing works

AMPK: A cellular metabolic and redox sensor. A minireview

Shirwany, N. A. (2014) · Frontiers in bioscience · doi:10.2741/4218 · Cited by 142 · see citing works

The Warburg Effect in Endothelial Cells and its Potential as an Anti-angiogenic Target in Cancer

Fitzgerald, G., Soro-Arnáiz, I., & Bock, K. D. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00100 · Cited by 135 · see citing works

AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury

Marino, A., Hausenloy, D. J., Andreadou, I., Horman, S., Bertrand, L., & Beauloye, C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.047 · Cited by 134 · see citing works

Chronic metformin treatment improves post‐stroke angiogenesis and recovery after experimental stroke

Venna, V. R., Li, J., Hammond, M. D., Mancini, N. S., & McCullough, L. D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12556 · Cited by 134 · see citing works

AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

Dasgupta, B., & Milbrandt, J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.005 · Cited by 133 · see citing works

Flow Activation of AMP-Activated Protein Kinase in Vascular Endothelium Leads to Kruppel-Like Factor 2 Expression

Young, A., Wu, W., Sun, W., Larman, H. B., Wang, N., Li, Y.-S. J., Shyy, J. Y., Chien, S., & García‐Cardeña, G. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.193540 · Cited by 132 · see citing works

An essential role for SRC-activated STAT-3 in 14,15-EET–induced VEGF expression and angiogenesis

Cheranov, S. Y., Karpurapu, M., Wang, D., Zhang, B., Venema, R. C., & Rao, G. N. (2008) · Blood · doi:10.1182/blood-2007-11-126680 · Cited by 127 · see citing works

AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation

Mishra, R., Cool, B. L., Laderoute, K. R., Foretz, M., Viollet, B., & Simonson, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800902200 · Cited by 128 · see citing works

PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice

Leick, L., Hellsten, Y., Fentz, J., Lyngby, S. S., Wojtaszewski, J. F. P., Hidalgo, J., & Pilegaard, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2009 · Cited by 124 · see citing works

AMPK in cardiovascular health and disease

Shirwany, N. A., & Zou, M. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.139 · Cited by 121 · see citing works

Activation of AMP kinase α1 subunit induces aortic vasorelaxation in mice

Goirand, F., Solar, M., Athea, Y., Viollet, B., Mateo, P., Fortin, D., Leclerc, J., Hoerter, J., Ventura‐Clapier, R., & Garnier, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.132589 · Cited by 121 · see citing works

Effect of metformin on the proliferation, migration, and MMP-2 and-9 expression of human umbilical vein endothelial cells

ESFAHANIAN, N., SHAKIBA, Y., NIKBIN, B., SORAYA, H., MALEKI-DIZAJI, N., GHAZI-KHANSARI, M., & GARJANI, A. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.753 · Cited by 120 · see citing works

Modulation of endothelium function by fatty acids

Mallick, R., & Duttaroy, A. K. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04260-9 · Cited by 122 · see citing works

Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems

Song, P., & Zou, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.025 · Cited by 119 · see citing works

Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes

Andreev, D. E., O’Connor, P. B. F., Zhdanov, A. V., Dmitriev, R. I., Shatsky, I. N., Papkovsky, D. B., & Baranov, P. V. (2015) · Genome biology · doi:10.1186/s13059-015-0651-z · Cited by 111 · see citing works

AMP‐ACTIVATED PROTEIN KINASE ACTIVATION AS A STRATEGY FOR PROTECTING VASCULAR ENDOTHELIAL FUNCTION

Zou, M., & Wu, Y. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04851.x · Cited by 115 · see citing works

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis

Webler, A. C., Michaelis, U. R., Popp, R., Barbosa‐Sicard, E., Murugan, A., Falck, J. R., Fißlthaler, B., & Fleming, I. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2008 · Cited by 114 · see citing works

AMPK-Dependent Metabolic Regulation by PPAR Agonists

Lee, W. H., & Kim, S. G. (2010) · PPAR Research · doi:10.1155/2010/549101 · Cited by 114 · see citing works

Estradiol-Mediated Endothelial Nitric Oxide Synthase Association With Heat Shock Protein 90 Requires Adenosine Monophosphate-Dependent Protein Kinase

Schulz, E., Anter, E., Zou, M., & Keaney, J. F. (2005) · Circulation · doi:10.1161/circulationaha.105.546812 · Cited by 114 · see citing works

Protein Modification by O-Linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells

Luo, B., Soesanto, Y., & McClain, D. A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159533 · Cited by 112 · see citing works

Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice

Omura, J., Satoh, K., Kikuchi, N., Satoh, T., Kurosawa, R., Nogi, M., Otsuki, T., Kozu, K., Numano, K., Suzuki, K., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.308178 · Cited by 111 · see citing works

AMPK and vasculoprotection

Ewart, M., & Kennedy, S. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.11.002 · Cited by 110 · see citing works

Integrin-Linked Kinase, a Hypoxia-Responsive Molecule, Controls Postnatal Vasculogenesis by Recruitment of Endothelial Progenitor Cells to Ischemic Tissue

Lee, S., Youn, S., Cho, H., Li, L., Kim, T.-Y., Yook, H.-S., Chung, J.-W., Hur, J., Yoon, C., Park, K. W., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.595918 · Cited by 108 · see citing works

Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila

Johnson, E. C., Kazgan, N., Bretz, C. A., Forsberg, L. J., Hector, C. E., Worthen, R. J., Onyenwoke, R. U., & Brenman, J. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012799 · Cited by 105 · see citing works

Skeletal Muscle Capillarity during Hypoxia: VEGF and Its Activation

Breen, E. C., Tang, K., Olfert, M., Knapp, A. E., & Wagner, P. D. (2008) · High Altitude Medicine & Biology · doi:10.1089/ham.2008.1010 · Cited by 103 · see citing works

Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells

Abaci, H. E., Truitt, R., Luong, E., Drazer, G., & Gerecht, S. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00484.2009 · Cited by 101 · see citing works

Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway

Xing, S.-S., Yang, X.-Y., Zheng, T., Li, W.-J., Wu, D., Chi, J.-Y., Bian, F., Bai, X.-L., Wu, G.-J., Zhang, Y.-Z., et al. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.07.004 · Cited by 99 · see citing works

Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis

Xie, Z., Dong, Y., Zhang, J., Scholz, R., Neumann, D., & Zou, M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01417-08 · Cited by 98 · see citing works

Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase

Stahmann, N., Woods, A., Spengler, K., Heslegrave, A., Bauer, R., Krause, S., Viollet, B., Carling, D., & Heller, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108688 · Cited by 98 · see citing works

Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 96 · see citing works

Cardiovascular and metabolic effects of Berberine

Affuso, F. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i4.71 · Cited by 94 · see citing works

The prokineticin receptor‐1 (GPR73) promotes cardiomyocyte survival and angiogenesis

Urayama, K., Guilini, C., Messaddeq, N., Hu, K., Steenman, M., Kurose, H., Ert, G., & Nebigil, C. G. (2007) · The FASEB Journal · doi:10.1096/fj.07-8116com · Cited by 94 · see citing works

Anti-Angiogenic Properties of Ginsenoside Rg3

Nakhjavani, M., Smith, E., Townsend, A. R., Price, T. J., & Hardingham, J. E. (2020) · Molecules · doi:10.3390/molecules25214905 · Cited by 93 · see citing works

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production

Reihill, J. A., Ewart, M., Hardie, D. G., & Salt, I. P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.110 · Cited by 91 · see citing works

AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling

Horman, S., Beauloye, C., Vanoverschelde, J., & Bertrand, L. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0102-z · Cited by 90 · see citing works

The Homeobox Gene Gax Inhibits Angiogenesis through Inhibition of Nuclear Factor-κB–Dependent Endothelial Cell Gene Expression

Patel, S., Leal, A. D., & Gorski, D. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3431 · Cited by 93 · see citing works

Evidence of cancer‐promoting roles for AMPK and related kinases

Monteverde, T., Muthalagu, N., Port, J., & Murphy, D. J. (2015) · FEBS Journal · doi:10.1111/febs.13534 · Cited by 88 · see citing works

Metabolic activation of AMP kinase in vascular smooth muscle

Rubin, L. J., Magliola, L., Feng, X., JONES, A. W., & Hale, C. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00075.2004 · Cited by 88 · see citing works

Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth

Son, J. S., Liu, X., Tian, Q., Zhao, L., Chen, Y., Hu, Y., Chae, S. A., de Avila, J. M., Zhu, M. J., & Du, ‬. (2019) · The Journal of Physiology · doi:10.1113/jp277698 · Cited by 86 · see citing works

High-fat diet induces endothelial dysfunction through a down-regulation of the endothelial AMPK-PI3K-Akt-eNOS pathway

García‐Prieto, C. F., Hernández-Nuño, F., Rio, D. D., Ruiz‐Hurtado, G., Aránguez, I., Ruiz‐Gayo, M., Somoza, B., & Fernández‐Alfonso, M. S. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400539 · Cited by 86 · see citing works

Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury

Miyabe, M., Ohashi, K., Shibata, R., Uemura, Y., Ogura, Y., Yuasa, D., Kambara, T., Kataoka, Y., Yamamoto, T., Matsuo, K., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu105 · Cited by 86 · see citing works

Adiponectin Promotes Revascularization of Ischemic Muscle through a Cyclooxygenase 2-Dependent Mechanism

Ohashi, K., Ouchi, N., Sato, K., Higuchi, A., Ishikawa, T., Herschman, H. R., Kihara, S., & Walsh, K. X. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00126-09 · Cited by 83 · see citing works

Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1-EPHA2 forward signaling

Han, B., Zhang, H., Tian, R., Liu, H., Wang, Z., Wang, Z., Tian, J., Cui, Y., Ren, S., Zuo, X., et al. (2022) · Theranostics · doi:10.7150/thno.72404 · Cited by 84 · see citing works

Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

Lopez‐Lopez, C., Dietrich, M. O., Metzger, F., Loetscher, H., & Torres‐Alemán, I. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4345-06.2007 · Cited by 83 · see citing works

AMP-activated protein kinase conducts the ischemic stress response orchestra

Young, L. H. (2008) · Circulation · doi:10.1161/circulationaha.107.713115 · Cited by 82 · see citing works

Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells

Kaneko, K., Yagui, K., Tanaka, A., Yoshihara, K., Ishikawa, K., Takahashi, K., Bujo, H., Sakurai, K., & Saitō, Y. (2008) · Microvascular Research · doi:10.1016/j.mvr.2007.12.003 · Cited by 82 · see citing works

ICAM-1–mediated Endothelial Nitric Oxide Synthase Activation via Calcium and AMP-activated Protein Kinase Is Required for Transendothelial Lymphocyte Migration

Martinelli, R., Gegg, M. E., Longbottom, R. E., Adamson, P., Turowski, P., & Greenwood, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-06-0636 · Cited by 82 · see citing works

Cytokines in Stress

Giannantonio, M. D., Frydas, S., Kempuraj, D., Karagouni, E., Hatzistilianou, M. N., Conti, C. M., Boucher, W. S., Papadopoulou, N., Donelan, J., Cao, J., et al. (2005) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200501800101 · Cited by 82 · see citing works

Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells

Kimura, T., Tomura, H., Sato, K., Ito, M., Matsuoka, I., Im, D., Kuwabara, A., Mogi, C., Itoh, H., Kurose, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.043869 · Cited by 81 · see citing works

The role of AMP-activated protein kinase in the cardiovascular system

Nagata, D., & Hirata, Y. (2009) · Hypertension Research · doi:10.1038/hr.2009.187 · Cited by 81 · see citing works

The Effect of AMPK on Angiogenesis in Endothelial Cells

Xiao-ma, Y. (2014) · Medical Recapitulate · Cited by 1 · see citing works

AMPK and hypoxia: crosstalk in the endothelium

Kabir, L. (2024) · doi:10.25560/130705

Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310389200 · Cited by 759 · see citing works

Dual Roles of the AMP-Activated Protein Kinase Pathway in Angiogenesis

Li, Y., Sun, R., Zou, J., Ying, Y., & Luo, Z. (2019) · Cells · doi:10.3390/cells8070752 · Cited by 111 · see citing works

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

Fisslthaler, B., & Fleming, I. (2009) · Circulation Research · doi:10.1161/circresaha.109.201590 · Cited by 295 · see citing works