Lee, Tong Ihn

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 4,505

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 4,143

Super-enhancers in the control of cell identity and disease

Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 3,662

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 2,961

Transcriptional Regulatory Networks in Saccharomyces cerevisiae

Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science

Gene Regulatory Network AnalysisFungal and yeast genetics research

Cited by 2,956

Coactivator condensation at super-enhancers links phase separation and gene control

Sabari, B. R., Dall’Agnese, A., Boija, A., Klein, I. A., Coffey, E. L., Shrinivas, K., Abraham, B. J., Hannett, N. M., Zamudio, A. V., Manteiga, J. C., et al. (2018) · Science

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 2,595

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Boija, A., Klein, I. A., Sabari, B. R., Dall’Agnese, A., Coffey, E. L., Zamudio, A. V., Li, C. H., Shrinivas, K., Manteiga, J. C., Hannett, N. M., et al. (2018) · Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 1,815

Dissecting the regulatory circuitry of a eukaryotic genome

Holstege, F. C. P., Jennings, E. G., Wyrick, J. J., Lee, T. I., Hengartner, C. J., Green, M. R., Golub, T. R., Lander, E. S., & Young, R. A. (1998) · Cell

Genomics and Chromatin DynamicsFungal and yeast genetics research

Cited by 1,670

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Hnisz, D., Weintraub, A. S., Day, D. S., Valton, A.-L., Bak, R. O., Li, C. H., Goldmann, J., Lajoie, B. R., Fan, Z. P., Sigova, A. A., et al. (2016) · Science

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,042

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes

Dowen, J. M., Fan, Z. P., Hnisz, D., Ren, G., Abraham, B. J., Zhang, L. N., Weintraub, A. S., Schuijers, J., Lee, T. I., Zhao, K., et al. (2014) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 884

Revisiting Global Gene Expression Analysis

Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 616

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

Hnisz, D., Schuijers, J., Lin, C. Y., Weintraub, A. S., Abraham, B. J., Lee, T. I., Bradner, J. E., & Young, R. A. (2015) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 476

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

Ji, X., Dadon, D. B., Powell, B. E., Fan, Z. P., Borges-Rivera, D., Shachar, S., Weintraub, A. S., Hnisz, D., Pegoraro, G., Lee, T. I., et al. (2016) · Cell Stem Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 400

Transcription factors interact with RNA to regulate genes

Oksuz, O., Henninger, J. E., Warneford-Thomson, R., Zheng, M. M., Erb, H., Vancura, A., Overholt, K. J., Hawken, S. W., Banani, S. F., Lauman, R., et al. (2023) · Molecular Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 275

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity

D’Alessio, A. C., Fan, Z. P., Wert, K. J., Baranov, P., Cohen, M. A., Saini, J. S., Cohick, E., Charniga, C., Dadon, D., Hannett, N. M., et al. (2015) · Stem Cell Reports

Pluripotent Stem Cells ResearchGenomics and Chromatin Dynamics

Cited by 172

Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer

Witt, A. E., Lee, C.-W., Lee, T. I., Azzam, D. J., Wang, B., Caslini, C., Petrocca, F., Grosso, J., Jones, M., Cohick, E. B., et al. (2017) · Oncogene

Cancer Cells and MetastasisHistone Deacetylase Inhibitors Research

Cited by 172

Protein codes promote selective subcellular compartmentalization

Kilgore, H. R., Chinn, I., Mikhael, P. G., Mitnikov, I., Van Dongen, C., Zylberberg, G., Afeyan, L., Banani, S. F., Wilson-Hawken, S., Lee, T. I., et al. (2025) · Science

Machine Learning in BioinformaticsProtein Structure and Dynamics

Cited by 99

Protein codes promote selective subcellular compartmentalization

Kilgore, H. R., Chinn, I., Mikhael, P. G., Mitnikov, I., Van Dongen, C., Zylberberg, G., Afeyan, L., Banani, S., Wilson-Hawken, S., Lee, T. I., et al. (2024) · Science

Machine Learning in BioinformaticsProtein Structure and Dynamics

Cited by 99