Adamski, Jerzy

Human metabolic individuality in biomedical and pharmaceutical research

CARDIoGRAM, Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., Wägele, B., Altmaier, E., Deloukas, P., Erdmann, J., et al. (2011) · Nature

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 1,017

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

Floegel, A., Stefan, N., Yu, Z., Mühlenbruch, K., Drogan, D., Joost, H.-G., Fritsche, A., Häring, H.-U., Hrabě de Angelis, M., Peters, A., et al. (2013) · Diabetes

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 988

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

Zeilinger, S., Kühnel, B., Klopp, N., Baurecht, H., Kleinschmidt, A., Gieger, C., Weidinger, S., Lattka, E., Adamski, J., Peters, A., et al. (2013) · PLoS ONE

Epigenetics and DNA MethylationSmoking Behavior and Cessation

Cited by 824

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

Gieger, C., Geistlinger, L., Altmaier, E., Hrabé de Angelis, M., Kronenberg, F., Meitinger, T., Mewes, H.-W., Wichmann, H.-E., Weinberger, K. M., Adamski, J., et al. (2008) · PLoS Genetics

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 737

Novel biomarkers for pre-diabetes identified by metabolomics

Wang‐Sattler, R., Yu, Z., Herder, C., Messias, A. C., Floegel, A., He, Y., Heim, K., Campillos, M., Holzapfel, C., Thorand, B., et al. (2012) · Molecular Systems Biology

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 701

A genome-wide perspective of genetic variation in human metabolism

Illig, T., Gieger, C., Zhai, G., Römisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmüller, G., Kato, B. S., Mewes, H.-W., et al. (2010) · Nature Genetics

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 653

Genetic diagnosis of Mendelian disorders via RNA sequencing

Kremer, L. S., Bader, D. M., Mertes, C., Kopajtich, R., Pichler, G., Iuso, A., Haack, T. B., Graf, E., Schwarzmayr, T., Terrile, C., et al. (2017) · Nature Communications

Genomics and Rare DiseasesMitochondrial Function and Pathology

Cited by 590

Rapamycin extends murine lifespan but has limited effects on aging

Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 374

The role of 17 beta-hydroxysteroid dehydrogenases

Mindnich, R., Möller, G., & Adamski, J. (2004) · Molecular and Cellular Endocrinology

Sexual Differentiation and DisordersSteroid Chemistry and Biochemistry

Cited by 354

Human serum metabolic profiles are age dependent

Yu, Z., Zhai, G., Singmann, P., He, Y., Xu, T., Prehn, C., Römisch‐Margl, W., Lattka, E., Gieger, C., Soranzo, N., et al. (2012) · Aging Cell

Metabolomics and Mass Spectrometry StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 340

The dynamic range of the human metabolome revealed by challenges

Krug, S., Kastenmüller, G., Stückler, F., Rist, M. J., Skurk, T., Sailer, M., Raffler, J., Römisch‐Margl, W., Adamski, J., Prehn, C., et al. (2012) · The FASEB Journal

Metabolomics and Mass Spectrometry StudiesHealth, Environment, Cognitive Aging

Cited by 327

17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

Peltoketo, H., Luu-The, V, Simard, J., & Adamski, J. (1999) · Journal of Molecular Endocrinology

Steroid Chemistry and BiochemistrySexual Differentiation and Disorders

Cited by 302

Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma

Siskos, A. P., Jain, P., Römisch-Margl, W., Bennett, M., Achaintre, D., Asad, Y., Marney, L., Richardson, L., Koulman, A., Griffin, J. L., et al. (2017) · Analytical Chemistry

Metabolomics and Mass Spectrometry StudiesClinical Laboratory Practices and Quality Control

Cited by 269

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development

Marchais-Oberwinkler, S., Henn, C., Möller, G., Klein, T., Negri, M., Oster, A., Spadaro, A., Werth, R., Wetzel, M., Xu, K., et al. (2011) · The Journal of Steroid Biochemistry and Molecular Biology

Estrogen and related hormone effectsSteroid Chemistry and Biochemistry

Cited by 216

Molecular cloning of a novel widely expressed human 80 kDa 17 β -hydroxysteroid dehydrogenase IV

Adamski, J., Normand, T., Leenders, F., Monté, D., Begue, A., Stéhelin, D., Jungblut, P. W., & de Launoit, Y. (1995) · Biochemical Journal

Steroid Chemistry and BiochemistryEstrogen and related hormone effects

Cited by 214

Integrated view on 17beta-hydroxysteroid dehydrogenases

Moeller, G., & Adamski, J. (2009) · Molecular and Cellular Endocrinology

Steroid Chemistry and BiochemistryAdrenal Hormones and Disorders

Cited by 214

A metabolome-wide association study of kidney function and disease in the general population

Sekula, P., Goek, O.-N., Quaye, L., Barrios, C., Levey, A. S., Römisch-Margl, W., Menni, C., Yet, I., Gieger, C., Inker, L. A., et al. (2016) · Journal of the American Society of Nephrology

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

Cited by 203

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information

Krumsiek, J., Suhre, K., Evans, A. M., Mitchell, M. W., Mohney, R. P., Milburn, M. V., Wägele, B., Römisch-Margl, W., Illig, T., Adamski, J., et al. (2012) · PLoS Genetics

Metabolomics and Mass Spectrometry StudiesBioinformatics and Genomic Networks

Cited by 197

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

Petersen, A.-K., Zeilinger, S., Kastenmüller, G., Römisch-Margl, W., Brugger, M., Peters, A., Meisinger, C., Strauch, K., Hengstenberg, C., Pagel, P., et al. (2014) · Human Molecular Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 183

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior

Cornelis, M. C., Kacprowski, T., Menni, C., Gustafsson, S., Pivin, E., Adamski, J., Artati, A., Eap, C. B., Ehret, G., Friedrich, N., et al. (2016) · Human Molecular Genetics

Coffee research and impactsGenetic Associations and Epidemiology

Cited by 175

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Volpato, V., Smith, J., Sandor, C., Ried, J. S., Baud, A., Handel, A., Newey, S. E., Wessely, F., Attar, M., Whiteley, E., et al. (2018) · Stem Cell Reports

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 165

Peroxisomal d -hydroxyacyl-CoA dehydrogenase deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency

van Grunsven, E. G., van Berkel, E., Ijlst, L., Vreken, P., de Klerk, J. B. C., Adamski, J., Lemonde, H., Clayton, P. T., Cuebas, D. A., & Wanders, R. J. A. (1998) · Proceedings of the National Academy of Sciences

Metabolism and Genetic DisordersNeurological diseases and metabolism

Cited by 152

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis

Vouk, K., Hevir, N., Ribič-Pucelj, M., Haarpaintner, G., Scherb, H., Osredkar, J., Möller, G., Prehn, C., Rižner, T. L., & Adamski, J. (2012) · Human Reproduction

Endometriosis Research and TreatmentMetabolomics and Mass Spectrometry Studies

Cited by 143

Metabolites associate with kidney function decline and incident chronic kidney disease in the general population

Goek, O.-N., Prehn, C., Sekula, P., Römisch-Margl, W., Döring, A., Gieger, C., Heier, M., Koenig, W., Wang-Sattler, R., Illig, T., et al. (2013) · Nephrology Dialysis Transplantation

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

Cited by 143