Integrated view on 17beta-hydroxysteroid dehydrogenases

Moeller, Gabriele; Adamski, Jerzy

doi:10.1016/j.mce.2008.10.040

Cited by 226Steroid Chemistry and BiochemistryAdrenal Hormones and DisordersHormonal Regulation and Hypertension

Integrated view on 17beta-hydroxysteroid dehydrogenases

Moeller, Gabriele, Adamski, Jerzy·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2008.10.040

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Abstract

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid metabolism. Long known members of the protein family seemed to be well characterised concerning their role in the regulation of the biological potency of steroid hormones, but today more and more evidence points to pivotal contributions of these enzymes in a variety of other metabolic pathways. Therefore, studies on 17beta-HSDs develop towards metabolomic survey. Latest research results give new insights into the complex metabolic interconnectivity of the 17beta-HSDs. In this paper metabolic activities of 17beta-HSDs will be compared, their interplay with endogenous substrates summarised, and interlacing pathways depicted. Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented.

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Transgenic Male Mice Expressing Human Hydroxysteroid Dehydrogenase 2 Indicate a Role for the Enzyme Independent of Its Action on Sex Steroids
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Molecular Changes in the D-Bifunctional Protein cDNA Sequence in Australasian Patients Belonging to the Bifunctional Protein Complementation Group
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Cloning and Characterization of a 5′ Regulatory Region of the Prolactin Receptor-Associated Protein/17β Hydroxysteroid Dehydrogenase 7 Gene
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3 -Hydroxysteroid Dehydrogenase/ 5->4-Isomerase Activity Associated with the Human 17 -Hydroxysteroid Dehydrogenase Type 2 Isoform
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Transcriptional regulation of the human type 8 17β-hydroxysteroid dehydrogenase gene by C/EBPβ
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Menstrual Cycle Markers of Ovarian Aging and Sex Steroid Hormone Genotypes
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Lack of association between common polymorphisms in the 17β-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche
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Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer
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Ten Polymorphisms of Estrogen-Metabolizing Genes and a Family History of Colon Cancer—An Association Study of Multiple Gene-Gene Interactions
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A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer
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Single‐nucleotide polymorphisms in the 17β‐hydroxysteroid dehydrogenase genes might predict the risk of side‐effects of estramustine phosphate sodium in prostate cancer patients
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A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
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Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management
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Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review
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“20 enzymes to cover in case of deficiency of another enzyme [107,114].”
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
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An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation
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Steroids in teleost fishes: A functional point of view
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Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
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Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
“Several HSD17B isoforms are active in the liver (Moeller and Adamski, 2009) as well as HSD11B1, which oxidises 11-keto-ste-”
Influential
17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development
Marchais-Oberwinkler, S., Henn, C., Möller, G., Klein, T., Negri, M., Oster, A., Spadaro, A., Werth, R., Wetzel, M., Xu, K., et al. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.013 · Cited by 216 · see citing works
Self-citation
Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases
Kaserer, T., Beck, K. R., Akram, M., Odermatt, A., & Schuster, D. (2015) · Molecules · doi:10.3390/molecules201219880 · Cited by 208 · see citing works
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?
Storbeck, K.-H., Bloem, L. M., Africander, D., Schloms, L., Swart, P., & Swart, A. C. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.006 · Cited by 198 · see citing works
The structural biology of oestrogen metabolism
THOMAS, M. P., & Potter, B. V. L. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.12.014 · Cited by 181 · see citing works
Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis
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Structural and functional biology of aldo-keto reductase steroid transforming enzymes
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Sex hormone metabolism in lung development and maturation
Seaborn, T., Simard, M., Provost, P. R., Piedbœuf, B., & Tremblay, Y. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.09.001 · Cited by 152 · see citing works
Hydroxysteroid dehydrogenases (HSDs) in bacteria – A bioinformatic perspective
Kisiela, M., Skarka, A., Ebert, B., & Maser, E. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.08.002 · Cited by 138 · see citing works
Steroidogenesis and its regulation in teleost-a review
Anbazhagan, R., & Senthilkumaran, B. (2020) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00752-0 · Cited by 131 · see citing works
The diversity of sex steroid action: novel functions of hydroxysteroid (17β) dehydrogenases as revealed by genetically modified mouse models
Saloniemi, T., Jokela, H., Strauss, L., Pakarinen, P., & POUTANEN, M. H. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0315 · Cited by 112 · see citing works
Estrogen biosynthesis and signaling in endometriosis
Huhtinen, K., Ståhle, M., Perheentupa, A., & Poutanen, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.022 · Cited by 107 · see citing works
Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation
Ma, W., Cojocaru, R. I., Gotoh, N., Gieser, L. M., Villasmil, R., Cogliati, T., Swaroop, A., & Wong, W. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.022 · Cited by 107 · see citing works
Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors
Baker, M. E., Nelson, D. R., & Studer, R. A. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.10.020 · Cited by 99 · see citing works
The Clinical and Molecular Heterogeneity of 17βHSD-3 Enzyme Deficiency
George, M. M., New, M. I., Ten, S., Sultan, C., & Bhangoo, A. (2010) · Hormone Research in Paediatrics · doi:10.1159/000318004 · Cited by 102 · see citing works
Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors
Baker, M. E. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.07.013 · Cited by 93 · see citing works
Steroidogenic Enzymes in the Brain: Morphological Aspects
Pelletier, G. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81011-4 · Cited by 94 · see citing works
The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells
Schloms, L., Storbeck, K., Swart, P., Gelderblom, W. C. A., & Swart, A. C. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.11.003 · Cited by 89 · see citing works
The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility
Kemiläinen, H., Adam, M., Mäki-Jouppila, J. H., Damdimopoulou, P., Damdimopoulos, A. E., Kere, J., Hovatta, O., Laajala, T. D., Aittokallio, T. A., Adamski, J., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1252 · Cited by 85 · see citing works
Binary and ternary crystal structure analyses of a novel inhibitor with 17β-HSD type 1: a lead compound for breast cancer therapy
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17β-Hydroxysteroid dehydrogenase inhibitors: a patent review
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Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders
Yang, S., He, X., Isaacs, C. E., Dobkin, C., Miller, D. L., & Philipp, M. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.07.001 · Cited by 82 · see citing works
Ovarian aromatase loss-of-function mutant medaka undergo ovary degeneration and partial female-to-male sex reversal after puberty
Nakamoto, M., Shibata, Y., Ohno, K., Usami, T., Kamei, Y., Taniguchi, Y., Todo, T., Sakamoto, T., Young, G., Swanson, P., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.013 · Cited by 79 · see citing works
Ovarian steroidogenesis and the role of sex steroid hormones on ovarian growth and maturation of the Japanese eel
Kazeto, Y., Tosaka, R., Matsubara, H., Ijiri, S., & Adachi, S. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.013 · Cited by 76 · see citing works
Minireview: Androgen Metabolism in Castration-Resistant Prostate Cancer
Sharifi, N. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1007 · Cited by 75 · see citing works
Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer
Rižner, T. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.026 · Cited by 75 · see citing works
Overexpression of 17β-Hydroxysteroid Dehydrogenase Type 1 Increases the Exposure of Endometrial Cancer to 17β-Estradiol
Cornel, K. M. C., Kruitwagen, R. F. P. M., Delvoux, B., Visconti, L. M., de Vijver, K. K. V., Day, J. M., Gorp, T. V., Hermans, R. J. J., Dunselman, G. A. J., & Romano, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2994 · Cited by 64 · see citing works
Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery
Konings, G. F. J., Brentjens, L. S., Delvoux, B., Linnanen, T., Cornel, K. M. C., Koskimies, P., Bongers, M. Y., Kruitwagen, R. F. P. M., Xanthoulea, S., & Romano, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00940 · Cited by 65 · see citing works
Characteristics and sex dimorphism of 17β-hydroxysteroid dehydrogenase family genes in the olive flounder Paralichthys olivaceus
Zou, C., Wang, L., Zou, Y., Wu, Z., Wang, W., Liang, S., Wang, L., & You, F. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105597 · Cited by 61 · see citing works
Engineering Mycobacterium smegmatis for testosterone production
Fernández‐Cabezón, L., Galán, B., & García, J. L. (2016) · Microbial Biotechnology · doi:10.1111/1751-7915.12433 · Cited by 58 · see citing works
Hydroxysteroid (17β) Dehydrogenase 12 Is Essential for Mouse Organogenesis and Embryonic Survival
Rantakari, P., Lagerbohm, H., Kaimainen, M., Suomela, J., Strauss, L., Sainio, K., Pakarinen, P., & POUTANEN, M. H. (2010) · Endocrinology · doi:10.1210/en.2009-0929 · Cited by 57 · see citing works
17β‐Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS
Chen, Z., Kastaniotis, A. J., Miinalainen, I., Venkatesan, R., Wierenga, R. K., & Hiltunen, J. K. (2009) · The FASEB Journal · doi:10.1096/fj.09-133587 · Cited by 56 · see citing works
Recent advances in 17beta-hydroxysteroid dehydrogenases
Prehn, C. P., Möller, G., & Adamski, J. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.12.024 · Cited by 55 · see citing works
A tale of two steroids: The importance of the androgens DHEA and DHEAS for early neurodevelopment
Greaves, R. F., Wudy, S. A., Badoer, E., Zacharin, M., Hirst, J. J., Quinn, T., & Walker, D. W. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.12.007 · Cited by 54 · see citing works
The Adrenal Cortex and its Disorders
Miller, W. L. (2009) · Wiley eBooks · doi:10.1002/9781444316728.ch13 · Cited by 51 · see citing works
Proteomic Analysis of Lipid Droplets from Caco-2/TC7 Enterocytes Identifies Novel Modulators of Lipid Secretion
Beilstein, F., Bouchoux, J., Rousset, M., & Demignot, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053017 · Cited by 50 · see citing works
Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2
Tokarz, J., Mindnich, R., Norton, W., Möller, G., Hrabé de Angelis, M., & Adamski, J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.022 · Cited by 48 · see citing works
Self-citation
Introduction of an Electron Withdrawing Group on the Hydroxyphenylnaphthol Scaffold Improves the Potency of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors
Wetzel, M., Marchais‐Oberwinkler, S., Perspicace, E., Möller, G., Adamski, J., & Hartmann, R. W. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2008453 · Cited by 47 · see citing works
Inhibition of type 1 17β-hydroxysteroid dehydrogenase impairs the synthesis of 17β-estradiol in endometriosis lesions
Delvoux, B., D'Hooghe, T., Kyama, C., Koskimies, P., Hermans, R. J. J., Dunselman, G. A., & Romano, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2851 · Cited by 59 · see citing works
Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus
Kimoto, T., Ishii, H., Higo, S., Hojo, Y., & Kawato, S. (2010) · Endocrinology · doi:10.1210/en.2010-0581 · Cited by 46 · see citing works
Identification of a 17β‐Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer’s Disease and Prostate Cancer
Ayan, D. P., Maltais, R., & Poirier, D. (2012) · ChemMedChem · doi:10.1002/cmdc.201200129 · Cited by 46 · see citing works
Structure-based design, synthesis and in vitro characterization of potent 17β-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone
Möller, G., Deluca, D., Gege, C., Rosinus, A., Kowalik, D., Peters, O., Droescher, P., Elger, W. A. G., Adamski, J., & Hillisch, A. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.09.113 · Cited by 45 · see citing works
Hydroxysteroid (17β) dehydrogenase X in human health and disease
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Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: Key tools for studying and treating estrogen-dependent diseases
Poirier, D. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.007 · Cited by 44 · see citing works
17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes
Hiltunen, J. K., Kastaniotis, A. J., Autio, K. J., Jiang, G., Chen, Z., & Glumoff, T. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.11.012 · Cited by 43 · see citing works
Steroid metabolism in cnidarians: Insights from Nematostella vectensis
Tarrant, A. M., Reitzel, A. M., Blomquist, C. H., Haller, F., Tokarz, J., & Adamski, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.037 · Cited by 41 · see citing works
Seasonal expression and cellular distribution of star and steroidogenic enzymes in quail testis
Rosati, L., Fiore, M. M. D., Prisco, M., Russo, F. D. G., Venditti, M., Andreuccetti, P., Baccari, G. C., & Santillo, A. (2019) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22896 · Cited by 41 · see citing works
Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily
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Recent advances in 17β-hydroxysteroid dehydrogenases.
Prehn, C., Möller, G., & Adamski, J. (2009) · Site cant be reached

Authors: Moeller, G., & Adamski, J.
Affiliations: Helmholtz Munich (DE)
ORCID: Adamski, Jerzy
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-03
Volume: 301
Issue: 1-2
Pages: 7-19
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2008.10.040
OpenAlex: W2048714965
Cited by: 214
References: 176
Citations by year: 2026: 5 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 17 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 11
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: 17β-hydroxysteroid dehydrogenase, steroid metabolism, steroid hormone regulation, metabolomics, endogenous substrates, genetic susceptibility, disease
MeSH terms: Animals, Disease, Humans, Polymorphism, Genetic, 17-Hydroxysteroid Dehydrogenases, Crystallography, X-Ray, Models, Animal

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Integrated view on 17beta-hydroxysteroid dehydrogenases

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