Coppola, Giovanni

Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTor

Oguro-Ando, A., Rosensweig, C., Herman, E., Nishimura, Y., Werling, D., Bill, B. R., Berg, J. M., Gao, F., Coppola, G., Abrahams, B. S., et al. (2015) · Molecular Psychiatry

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

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Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank

Van Hout, C. V., Tachmazidou, I., Backman, J. D., Hoffman, J. X., Ye, B., Pandey, A. K., Gonzaga-Jauregui, C., Khalid, S., Liu, D., Banerjee, N., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Rare DiseasesGenetic Associations and Epidemiology

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Plasma neurofilament light for prediction of disease progression in familial frontotemporal lobar degeneration

Rojas, J. C., Wang, P., Staffaroni, A. M., Heller, C., Cobigo, Y., Wolf, A., Goh, S.-Y. M., Ljubenkov, P. A., Heuer, H. W., Fong, J. C., et al. (2021) · Neurology

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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Inosine Alters Gene Expression and Axonal Projections in Neurons Contralateral to a Cortical Infarct and Improves Skilled Use of the Impaired Limb

Zai, L., Ferrari, C., Subbaiah, S., Havton, L. A., Coppola, G., Strittmatter, S., Irwin, N., Geschwind, D., & Benowitz, L. I. (2009) · Journal of Neuroscience

Nerve injury and regenerationStroke Rehabilitation and Recovery

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Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability

Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., Zhang, Z., Huang, Y., Temple, S., Coppola, G., et al. (2016) · Stem Cell Reports

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture

Miller, Z. A., Sturm, V. E., Camsari, G. B., Karydas, A., Yokoyama, J. S., Grinberg, L. T., Boxer, A. L., Rosen, H. J., Rankin, K. P., Gorno-Tempini, M. L., et al. (2016) · Neurology Neuroimmunology & Neuroinflammation

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

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Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database

Ringman, J. M., Monsell, S., Ng, D. W., Zhou, Y., Nguyen, A., Coppola, G., Van Berlo, V., Mendez, M. F., Tung, S., Weintraub, S., et al. (2016) · Journal of Neuropathology & Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

Steele, N. Z. R., Carr, J. S., Bonham, L. W., Geier, E. G., Damotte, V., Miller, Z. A., Desikan, R. S., Boehme, K. L., Mukherjee, S., Crane, P. K., et al. (2017) · PLOS Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., Park, C. S., Zhang, Z., Sandoval-Miller, S., Zhang, R. L., et al. (2015) · Neuron

Genetic Neurodegenerative DiseasesAmyotrophic Lateral Sclerosis Research

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Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease

Lalli, M. A., Bettcher, B. M., Arcila, M. L., Garcia, G., Guzman, C., Madrigal, L., Ramirez, L., Acosta-Uribe, J., Baena, A., Wojta, K. J., et al. (2015) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

Gendron, T. F., Heckman, M. G., White, L. J., Veire, A. M., Pedraza, O., Burch, A. R., Bozoki, A. C., Dickerson, B. C., Domoto-Reilly, K., Foroud, T., et al. (2022) · Cell Reports Medicine

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers

Meeter, L. H. H., Gendron, T. F., Sias, A. C., Jiskoot, L. C., Russo, S. P., Donker Kaat, L., Papma, J. M., Panman, J. L., van der Ende, E. L., Dopper, E. G., et al. (2018) · Annals of Clinical and Translational Neurology

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

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Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

Sirkis, D. W., Bonham, L. W., Aparicio, R. E., Geier, E. G., Ramos, E. M., Wang, Q., Karydas, A., Miller, Z. A., Miller, B. L., Coppola, G., et al. (2016) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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The longitudinal evaluation of familial frontotemporal dementia subjects protocol: framework and methodology

Boeve, B., Bove, J., Brannelly, P., Brushaber, D., Coppola, G., Dever, R., Dheel, C., Dickerson, B., Dickinson, S., Faber, K., et al. (2020) · Alzheimer's & Dementia

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Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration

Olney, N. T., Ong, E., Goh, S. M., Bajorek, L., Dever, R., Staffaroni, A. M., Cobigo, Y., Bock, M., Chiang, K., Ljubenkov, P., et al. (2020) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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A Shift in Microglial β‐Amyloid Binding in Alzheimer's Disease Is Associated with Cerebral Amyloid Angiopathy

Zabel, M., Schrag, M., Crofton, A., Tung, S., Beaufond, P., Van Ornam, J., DiNinni, A., Vinters, H. V., Coppola, G., & Kirsch, W. M. (2013) · Brain Pathology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort

Heuer, H. W., Wang, P., Rascovsky, K., Wolf, A., Appleby, B., Bove, J., Bordelon, Y., Brannelly, P., Brushaber, D. E., Caso, C., et al. (2020) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

Staffaroni, A. M., Cobigo, Y., Goh, S. M., Kornak, J., Bajorek, L., Chiang, K., Appleby, B., Bove, J., Bordelon, Y., Brannelly, P., et al. (2020) · Alzheimer's & Dementia

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Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials

Toller, G., Ranasinghe, K., Cobigo, Y., Staffaroni, A., Appleby, B., Brushaber, D., Coppola, G., Dickerson, B., Domoto-Reilly, K., Fields, J., et al. (2020) · Neurology

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Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

Geier, E. G., Bourdenx, M., Storm, N. J., Cochran, J. N., Sirkis, D. W., Hwang, J.-H., Bonham, L. W., Ramos, E. M., Diaz, A., Van Berlo, V., et al. (2019) · Acta Neuropathologica

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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Butler, V. J., Gao, F., Corrales, C. I., Cortopassi, W. A., Caballero, B., Vohra, M., Ashrafi, K., Cuervo, A. M., Jacobson, M. P., Coppola, G., et al. (2019) · PLOS Genetics

Genetics, Aging, and Longevity in Model OrganismsAmyotrophic Lateral Sclerosis Research

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Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C

Kawles, A., Nishihira, Y., Feldman, A., Gill, N., Minogue, G., Keszycki, R., Coventry, C., Spencer, C., Lilek, J., Ajroud, K., et al. (2022) · Brain

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Gyrification abnormalities in presymptomatic c9orf72 expansion carriers

Caverzasi, E., Battistella, G., Chu, S. A., Rosen, H., Zanto, T. P., Karydas, A., Shwe, W., Coppola, G., Geschwind, D. H., Rademakers, R., et al. (2019) · Journal of Neurology, Neurosurgery & Psychiatry

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Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease

Yokoyama, J. S., Bonham, L. W., Sears, R. L., Klein, E., Karydas, A., Kramer, J. H., Miller, B. L., & Coppola, G. (2015) · BMC Neurology

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