Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability
Open accessAbstract
Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly associated with tau mutations. However, the mechanism of neuronal loss is not fully understood. To identify molecular events associated with tauopathy, we studied induced pluripotent stem cell (iPSC)-derived neurons from individuals carrying the tau-A152T variant. We highlight the potential of in-depth phenotyping of human neuronal cell models for pre-clinical studies and identification of modulators of endogenous tau toxicity. Through a panel of biochemical and cellular assays, A152T neurons showed accumulation, redistribution, and decreased solubility of tau. Upregulation of tau was coupled to enhanced stress-inducible markers and cell vulnerability to proteotoxic, excitotoxic, and mitochondrial stressors, which was rescued upon CRISPR/Cas9-mediated targeting of tau or by pharmacological activation of autophagy. Our findings unmask tau-mediated perturbations of specific pathways associated with neuronal vulnerability, revealing potential early disease biomarkers and therapeutic targets for FTD and other tauopathies.
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CRBN inhibition alone may lead to accumulation of P-tau in A152T neurons, which are more sensitive to modulators of the proteasome than healthy neurons.
“indicating that CRBN inhibition alone may lead to accumulation of P-tau in these neurons, which are more sensitive to modulators of the proteasome than healthy neurons”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Silva et al., 2016
Patient-specific cellular models express tau at endogenous levels and recapitulate disease-relevant tau phenotypes ex vivo.
“These patient-specific cellular models that express tau at endogenous levels, recapitulate disease-relevant tau phenotypes ex vivo”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Silva et al., 2016
Control neuronal cultures contain reduced levels of low-solubility P-tauS396 species present in FTD-patient-derived neurons.
“These control neuronal cultures also contain reduced levels of the low-solubility P-tauS396 species present in the FTD-patient-derived neurons”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Silva et al., 2016
In FTD patient-derived neuronal cell models, accumulation of tau and P-tau of reduced solubility is coupled to increased cellular vulnerability to specific forms of stress.
“In FTD patient-derived neuronal cell models, accumulation of tau and P-tau of reduced solubility is coupled to increased cellular vulnerability to specific forms of stress (Silva et al., 2016).”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Silva et al., 2016
This effect on viability is not seen in WT control neurons and can be rescued by CRISPR/Cas9-mediated MAPT knockout in A152T neurons.
“This effect on viability is not seen in WT control neurons and can be rescued by CRISPR/Cas9-mediated MAPT knockout (KO) in A152T neurons”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Silva et al., 2016
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Self-citation
- Authors
- Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., Zhang, Z., Huang, Y., Temple, S., Coppola, G., Geschwind, D. H., Karydas, A., Miller, B. L., Kosik, K. S., Gao, F.-B., Steen, J. A., & Haggarty, S. J.
- Affiliations
- Harvard University (US)
- Boston Children's Hospital (US)
- University of Massachusetts Chan Medical School (US)
- University of California, San Francisco (US)
- Neural Stem Cell Institute (US)
- University of California, Los Angeles (US)
- University of California, Santa Barbara (US)
- Corresponding author
- Haggarty, Stephen J.
- ORCID
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 7
- Issue
- 3
- Pages
- 325-340
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC5032560
- OpenAlex
- W2516117108
- Cited by
- 103
- References
- 64
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 2
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- AFTD (1R21NS085487)
- Bluefield Project to Cure Frontotemporal Dementia (P50AG023501, P01AG019724)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- frontotemporal dementia, tauopathy, iPSC-derived neurons, neuronal vulnerability, tau aggregation, proteotoxicity, excitotoxicity, mitochondrial stress, autophagy, CRISPR/Cas9 genome editing, disease biomarkers, therapeutic target
- MeSH terms
- Autophagy, Cell Differentiation, Cell Line, Codon, Gene Expression Regulation, Humans, Mutation, Neurons, Protein Processing, Post-Translational, Stress, Physiological, Biomarkers, tau Proteins, Amino Acid Substitution, Protein Isoforms, Induced Pluripotent Stem Cells, Frontotemporal Dementia, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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