Zinn, Nico

Catalytic in vivo protein knockdown by small-molecule PROTACs

Bondeson, D. P., Mares, A., Smith, I. E. D., Ko, E., Campos, S., Miah, A. H., Mulholland, K. E., Routly, N., Buckley, D. L., Gustafson, J. L., et al. (2015) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 1,356

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Mares, A., Miah, A. H., Smith, I. E. D., Rackham, M., Thawani, A. R., Cryan, J., Haile, P. A., Votta, B. J., Beal, A. M., Capriotti, C., et al. (2020) · Communications Biology

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 232

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Woodcock, H. V., Eley, J. D., Guillotin, D., Platé, M., Nanthakumar, C. B., Martufi, M., Peace, S., Joberty, G., Poeckel, D., Good, R. B., et al. (2019) · Nature Communications

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPI3K/AKT/mTOR signaling in cancer

Cited by 224

Biological plasticity rescues target activity in CRISPR knock outs

Smits, A. H., Ziebell, F., Joberty, G., Zinn, N., Mueller, W. F., Clauder-Münster, S., Eberhard, D., Fälth Savitski, M., Grandi, P., Jakob, P., et al. (2019) · Nature Methods

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 219

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

Thomson, D. W., Poeckel, D., Zinn, N., Rau, C., Strohmer, K., Wagner, A. J., Graves, A. P., Perrin, J., Bantscheff, M., Duempelfeld, B., et al. (2019) · ACS Medicinal Chemistry Letters

interferon and immune responsesImmune Response and Inflammation

Cited by 103

Improved Proteomics-Based Drug Mechanism-of-Action Studies Using 16-Plex Isobaric Mass Tags

Zinn, N., Werner, T., Doce, C., Mathieson, T., Boecker, C., Sweetman, G., Fufezan, C., & Bantscheff, M. (2021) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 49

One-source peptide/phosphopeptide standards for accurate phosphorylation degree determination

Hahn, B., Böhm, M., Raia, V., Zinn, N., Möller, P., Klingmüller, U., & Lehmann, W. (2011) · PROTEOMICS

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 16