Jayadev, Suman

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., et al. (2022) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 2,498

Integrated multimodal cell atlas of Alzheimer’s disease

Gabitto, M. I., Travaglini, K. J., Rachleff, V. M., Kaplan, E. S., Long, B., Ariza, J., Ding, Y., Mahoney, J. T., Dee, N., Goldy, J., et al. (2023) · Nature Neuroscience

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 425

Integrated multimodal cell atlas of Alzheimer’s disease

Gabitto, M. I., Travaglini, K. J., Rachleff, V. M., Kaplan, E. S., Long, B., Ariza, J., Ding, Y., Mahoney, J. T., Dee, N., Goldy, J., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 397

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

Salloway, S., Farlow, M., McDade, E., Clifford, D. B., Wang, G., Llibre-Guerra, J. J., Hitchcock, J. M., Mills, S. L., Santacruz, A. M., Aschenbrenner, A. J., et al. (2021) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 359

Human Microglia Show Unique Transcriptional Changes in Alzheimer's Disease

Prater, K. E., Green, K. J., Mamde, S., Sun, W., Cochoit, A., Smith, C. L., Chiou, K. L., Heath, L., Rose, S. E., Wiley, J., et al. (2023) · Nature Aging

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 164

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

Korvatska, O., Leverenz, J. B., Jayadev, S., McMillan, P., Kurtz, I., Guo, X., Rumbaugh, M., Matsushita, M., Girirajan, S., Dorschner, M. O., et al. (2015) · JAMA Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 137

The p53 Transcription Factor Modulates Microglia Behavior through MicroRNA-Dependent Regulation of c-Maf

Su, W., Hopkins, S., Nesser, N. K., Sopher, B., Silvestroni, A., Ammanuel, S., Jayadev, S., Möller, T., Weinstein, J., & Garden, G. A. (2014) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulation

Cited by 103

Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A., Keene, C. D., de la Iglesia, H., Jayadev, S., et al. (2023) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 43

APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s disease pathology

Chemparathy, A., Le Guen, Y., Chen, S., Lee, E.-G., Leong, L., Gorzynski, J. E., Jensen, T. D., Ferrasse, A., Xu, G., Xiang, H., et al. (2024) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 43

The pro‐inflammatory microRNA miR‐155 influences fibrillar β‐Amyloid1‐42 catabolism by microglia

Aloi, M. S., Prater, K. E., Sopher, B., Davidson, S., Jayadev, S., & Garden, G. A. (2021) · Glia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 43

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia

Mishra, S., Morshed, N., Sidhu, S. B., Kinoshita, C., Stevens, B., Jayadev, S., & Young, J. E. (2025) · Glia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 31

Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases

Kobren, S. N., Baldridge, D., Velinder, M., Krier, J. B., LeBlanc, K., Esteves, C., Pusey, B. N., Züchner, S., Blue, E., Lee, H., et al. (2021) · Genetics in Medicine

Genomics and Rare DiseasesGenomics and Phylogenetic Studies

Cited by 27

Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons

Young, J. E., & Jayadev, S. (2022) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 10

Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias

EADB, Bellenguez, C., Castillo Morales, A., Amin, N., van der Lee, S. J., Muntaner, M., Parveen, K., Küçükali, F., Grenier-Boley, B., Heikkinen, S., et al. (2026) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 7